Molecular Engineering of Supramolecular Scaffold Coatings that Can Reduce Static Platelet Adhesion

Kumar, Aryavarta M. S.; Sivakova, Sona; Fox, Justin D.; Green, Jennifer E.; Marchant, Roger; Rowan, Stuart J.

doi:10.1021/ja0775927

Cited by 46 publications

(46 citation statements)

References 107 publications

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“…[31][32][33] The formation mechanism of such assemblies, particularly in aqueous environments, involves adsorption followed by the rearrangement of the molecules on the surface into hierarchical assemblies. [34,35] Thus, the tendency to form the nanoring structures by these carbon nanotubes after end-to-end functionalization with the uracil nucleobase, probably involves the adsorption of SWCNTs on the HOPG surface. Since the pyrimidine bases are known to feature poor adsorption energies on graphite, [36] this organization is further stabilized through uracil-uracil self base-pairing involving N3ÀH and C4=O.…”

Section: A C H T U N G T R E N N U N G Ringsmentioning

confidence: 99%

Carbon Nanotube–Nucleobase Hybrids: Nanorings from Uracil‐Modified Single‐Walled Carbon Nanotubes

Singh

Toma

Kumar

et al. 2011

Chemistry A European J

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Single-walled carbon nanotubes (SWCNTs) have been covalently functionalized with uracil nucleobase. The hybrids have been characterized by using complementary spectroscopic and microscopic techniques including solid-state NMR spectroscopy. The uracil-functionalized SWCNTs are able to self-assemble into regular nanorings with a diameter of 50-70 nm, as observed by AFM and TEM. AFM shows that the rings do not have a consistent height and thickness, which indicates that they may be formed by separate bundles of CNTs. The simplest model for the nanoring formation likely involves two bundles of CNTs interacting with each other via uracil-uracil base-pairing at both CNT ends. These nanorings can be envisaged for the development of advanced electronic circuits.

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Section: A C H T U N G T R E N N U N G Ringsmentioning

confidence: 99%

Carbon Nanotube–Nucleobase Hybrids: Nanorings from Uracil‐Modified Single‐Walled Carbon Nanotubes

Singh

Toma

Kumar

et al. 2011

Chemistry A European J

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“…We have recently been interested in the assembly of a range of more complex guanine derivatives deposited onto highly oriented pyrolytic graphite (HOPG) from aqueous solutions. We reported10 that homoditopic guanine end-capped n -alkanes (e.g. 4 ) deposited from water:DMSO solutions form molecular-sized epitaxially ordered bands on HOPG.…”

Section: Introductionmentioning

confidence: 99%

Effect of Monomer Structure and Solvent on the Growth of Supramolecular Nanoassemblies on a Graphite Surface

et al. 2008

Self Cite

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The self-assembly of high aspect ratio hierarchical surface assemblies, as observed by fluid tapping mode AFM, can be achieved through careful design of the supramolecular interactions between low molecular weight adsorbates. Needle-like assemblies of monotopic guanine end-capped alkanes grow on a graphite surface when deposited from a water:DMSO solution. The growth of these assemblies can be monitored by AFM in "real time" and the growth rate along the two different axes can be understood (through molecular modeling) in terms of the specific adsorbate-adsorbate interactions along those axes. Additionally, through judicious solvent selection (e.g. use of non-Hbonding solvents such as o-dichlorobenzene), which allow formation of hydrogen bonding aggregates in solution and influence the surface-adsorbate interactions, dramatically different surface assemblies of these guanine derivatives are obtained.

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“…[1][2][3][4][5] A guiding principle in this rapidly growing area is the ability of nanoparticles to mimic the high affinity and multivalent interactions that exist in cellular systems offering the potential for highly efficient synthetic diagnostic and therapeutic systems. [6][7][8][9][10][11][12] One clear advantage of nanomaterials lies in their potential to be used as noninvasive diagnostic tools with the capacity to combine multiple modalities on one probe and the longer term opportunities for simultaneous application as drug-delivery systems. Therefore, the development of a new generation of nano-sized theranostics is a very appealing goal for contemporary polymer scientists.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

Jackson¹,

Chandrasekharan²,

Shi³

et al. 2015

IJN

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Branched copolymer nanoparticles ( D h =20–35 nm) possessing 1,4,7, 10-tetraazacyclododecane- N , N ′, N ″, N ‴-tetraacetic acid macrocycles within their cores have been synthesized and applied as magnetic resonance imaging (MRI) nanosized contrast agents in vivo. These nanoparticles have been generated from novel functional monomers via reversible addition–fragmentation chain transfer polymerization. The process is very robust and synthetically straightforward. Chelation with gadolinium and preliminary in vivo experiments have demonstrated promising characteristics as MRI contrast agents with prolonged blood retention time, good biocompatibility, and an intravascular distribution. The ability of these nanoparticles to perfuse and passively target tumor cells through the enhanced permeability and retention effect is also demonstrated. These novel highly functional nanoparticle platforms have succinimidyl ester-activated benzoate functionalities within their corona, which make them suitable for future peptide conjugation and subsequent active cell-targeted MRI or the conjugation of fluorophores for bimodal imaging. We have also demonstrated that these branched copolymer nanoparticles are able to noncovalently encapsulate hydrophobic guest molecules, which could allow simultaneous bioimaging and drug delivery.

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Molecular Engineering of Supramolecular Scaffold Coatings that Can Reduce Static Platelet Adhesion

Cited by 46 publications

References 107 publications

Carbon Nanotube–Nucleobase Hybrids: Nanorings from Uracil‐Modified Single‐Walled Carbon Nanotubes

Carbon Nanotube–Nucleobase Hybrids: Nanorings from Uracil‐Modified Single‐Walled Carbon Nanotubes

Effect of Monomer Structure and Solvent on the Growth of Supramolecular Nanoassemblies on a Graphite Surface

Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents

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