Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients

Lo, An Chi; Kleer, Celina G.; Banerjee, Mousumi; Omar, Sherif; Khaled, Hussein; Eissa, Saad; Hablas, Ahmed; Douglas, Julie A.; Alford, Sharon Hensley; Merajver, Sofía D.; Soliman, Amr S.

doi:10.1007/s10549-007-9833-z

Cited by 19 publications

(38 citation statements)

References 31 publications

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“…Very little is known about IBC in Sub-Saharan Africa. Our studies and other studies mainly from Tunisia [14, 15], have depicted a higher proportion of IBC in North Africa compared to the U.S. [14]. Further studies are required to better define IBC in Sub-Saharan Africa with possible investigation into the association of infections with breast cancer incidence.…”

Section: Discussionmentioning

confidence: 48%

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Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Burson

Soliman

Ngoma

et al. 2010

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Purpose Breast cancer is a highly heterogeneous disease globally. Public health prevention measures require an understanding of the burden of breast cancer and its risk factors. The purpose of this study was to describe the clinical, pathologic, and epidemiologic characteristics of breast cancer patients in Tanzania. Methods Data was abstracted from the medical records of all breast cancer patients attending Ocean Road Cancer Institute (ORCI) over a 2-year period from July 2007 to June 2009. Tumor tissue paraffin blocks were collected for all patients with available tissues for the determination of estrogen receptor (ER) and progesterone receptor (PR). Data for all patients was analyzed descriptively and by using unconditional logistic regression, by comparing early stage (ES), defined as stages I and II and late stage (LS), defined as stages III and IV patients to obtain odds ratios (ORs), 95% confidence intervals (CIs), and P -values. Results Among the 488 patients, stage was determined for 356 patients, 90.7% of whom presented in LS. Of the 57 tumor tissues, 49.1% were ER−/PR−. Patients with ulceration (OR = 4.97; 95% CI = 1.07, 23.04; p = 0.04) and peau d’orange (OR = 6.78; 95% CI = 1.48, 31.17; p = 0.01) were more likely to present in LS rather than ES. Male breast cancer accounted for 2.9% of all breast cancers and inflammatory breast cancer (IBC) comprised 4.3–5.5% of cases based on registered t4d diagnosis or the criteria of IBC signs, if t4d was not reported in the medical records. Conclusion Most breast cancer patients in Tanzania are diagnosed at advanced disease stages with about half of the tumors being ER−/PR−. These data strongly support that reducing barriers to care, down-staging of disease at diagnosis, implementation of clinical guidelines for management of advanced cases, and palliative care are the four most essential factors that need to be addressed to reduce morbidity and mortality from breast cancer in Tanzania. Further research is needed to quantify the magnitude and molecular features of two relatively rare forms of breast cancer that may account for a greater proportion of the burden of breast cancer in Tanzania compared to the USA and Western Europe: male breast cancer and IBC.

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Section: Discussionmentioning

confidence: 48%

“…Our studies and others have shown a higher proportion of IBC patients in populations in North Africa compared to the U.S. [14–16] and distinct molecular features of the IBC cases in North Africa [17]. However, little is known about the rate or molecular features of IBC in other parts of Africa.…”

Section: Introductionmentioning

confidence: 47%

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Burson

Soliman

Ngoma

et al. 2010

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“…The Egyptian patients and their tumor characteristics are included in our previous publications [19,20]. Briefly, 41 IBC patients from the National Cancer Institute of Cairo University (NCI-Cairo), and 7 patients from the Gharbiah Cancer Registry in Tanta, were recruited during the period of September,2005 to December, 2006.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

Soliman

Kleer

Mrad

et al. 2012

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Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ±SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P = 0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.

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“…In this study the average age was 46.5 years and the majority of the patients (61.3%) were actually less than 50 years old. Elsewhere in Africa, some authors have even reported series with a lower average age, close to 40 years [15] [16].…”

Section: ) Epidemiological Characteristics -Frequencymentioning

confidence: 99%

Management of Inflammatory Breast Cancers in Subsaharian Africa Context

Dia¹,

Djanhan²,

Saki³

et al. 2018

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Objective: To report the experience of Gynecology Department of the University Hospital of Treichville in the management of the inflammatory breast cancers. Methodology: We conducted a retrospective and descriptive study on cases of the inflammatory breast cancers managed in the Gynecology Department of the University Hospital of Treichville, from January 2011 to December 2015. Results: We collected 44 cases of inflammatory breast cancer representing 17.9% of all breast cancers. The average age of patients was 46.5 years (32 -70 years) and among them, the majority had inadequate socioeconomic level (90.9%). The risk factor for cancer found in the majority of patients was the age of first menstrual periods before the age of 12 years (52.3%). The average consultation time was long (10 months) and several patients had extensive inflammatory signs (38.6%), with lymph node involvement (84.1%) and metastases (36.4%). At the histological analysis, the most common type was invasive ductal carcinoma (81.8%), SBR grade III (54.5%). Regarding treatment, mastectomy according to Patey associated with a chemotherapy was performed in 22.7% cases. The evolution has been marked by an overall 5-year survival of 20%. Conclusion: The management of inflammatory breast cancers was late and incomplete in our service making poor prognosis.

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Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients

Cited by 19 publications

References 31 publications

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

Management of Inflammatory Breast Cancers in Subsaharian Africa Context

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