Molecular Epidemiological Analysis of<i>env</i>and<i>pol</i>Sequences in Newly Diagnosed HIV Type 1-Infected, Untreated Patients in Hungary

Mezei, Mária; Ay, Eva; Koroknai, Anita; Tóth, Renáta; Balázs, Andrea; Bakos, Ágnes; Győri, Zoltán; Bánáti, Ferenc; Marschalkó, Márta; Kárpáti, Sarolta; Minárovits, János

doi:10.1089/aid.2011.0077

Cited by 15 publications

(13 citation statements)

References 16 publications

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“…28 Similarly, a rather high TDR prevalence of 16.6% was detected in a study performed in Hungary in a similar time frame (2008-2010). 29 However, no TDR was reported in a study from Montenegro, 30 although with a limited number of only 10 samples, as well as in a study from Cyprus, representing 88% of the known-living HIV-1-infected population in the country. 31 A rather low prevalence of primary resistance of 2/66 (3%) was found in a survey from Albania, a somewhat higher prevalence of 3.9% was described in Georgia, and, similarly, 4.7% was found in a recent study from Slovenia.…”

Section: Discussionmentioning

confidence: 93%

Ten Years Survey of Primary HIV-1 Resistance in Serbia: The Occurrence of Multiclass Resistance

Stanojević

Šiljić²,

SalemovicDubravka³

et al. 2014

AIDS Research and Human Retroviruses

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In Serbia, the first cases of HIV infection were reported in 1985, whereas antiretroviral (ARV) therapy has been in use since 1987. With this study we aimed to assess the occurrence and pattern of HIV resistance mutations among newly diagnosed patients in the period 2002-2011. The study prospectively included 181 adult patients. Genotypic HIV-1 drug resistance testing was performed and drug resistance was scored according to the 2009 WHO list for surveillance of drug resistance mutations (SDRMs). A bioinformatic approach was used to estimate the duration of infection by calculating the percentage of ambiguous basecalls per sequence, with a cutoff of 0.47% as the delimiter for recent infection. The overall prevalence of transmitted drug resistance (TDR) found in the study was 8.8% (16/181, 95% CI=5.5-13.8). Thirty-one percent of resistant samples contained multiple SDRMs. In particular, 5/16 patients with resistance carried viral strains with SDRMs to multiple ARV classes, hence one-third of resistant strains were multiclass resistant, including non-B strains. A total of 51.9% of samples (94/181) were classified as recent infection, with a significant increase in the second part of the study period. However, the prevalence of TDR in recent infection was 6.4% (6/94, 95% CI=2.9-13.2), not statistically different from that found in nonrecent infection. We showed a changing pattern of TDR mutations over the study period, with a substantial occurrence of multiclass resistance, across different HIV subtypes. Our results highlight the need for continued surveillance of primary resistance.

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Section: Discussionmentioning

confidence: 93%

Ten Years Survey of Primary HIV-1 Resistance in Serbia: The Occurrence of Multiclass Resistance

Stanojević

Šiljić²,

SalemovicDubravka³

et al. 2014

AIDS Research and Human Retroviruses

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“…Similarly in the Czech Republic and Slovakia, non-B strains were found almost exclusively in heterosexuals (Chabadova et al, 2014;Linka et al, 2008;Reinis et al, 2001). Between 2008 and 2010 in Hungary, 96.6% of the patients were infected with subtype B and 3.3% with subtype A (Mezei et al, 2011), whereas subtype C was detected during the late 90s in an isolated case, where the virus was contracted in Africa (Mezei et al, 2000).…”

Section: Central Europementioning

confidence: 92%

Molecular epidemiology of HIV-1 infection in Europe: An overview

Beloukas

Psarris

Giannelou

et al. 2016

Infection, Genetics and Evolution

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“…Subtype B prevails in HIV infections in central European counties including Poland, Slovakia, the Czech Republic, Hungary, and most Balkan states although some non-B strains including A1 have been identified, especially among persons infected heterosexually or through injecting drug use (Chabadová et al, 2014; Habekova et al, 2010; Linka et al, 2008; Mezei et al, 2011; Reinis et al, 2001; Smoleń-Dzirba et al, 2012; Stanojevic et al, 2012). In Romania, however, HIV spread probably through contaminated needles/syringes used for therapeutic injections and seriously affected newborns and children in orphanages (Hersh et al, 1993, 1991).…”

Section: Molecular Epidemiology Of Hiv Among Pwid In Western and Cmentioning

confidence: 99%

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

Nikolopoulos

Kostaki

Paraskevis

2016

Infection, Genetics and Evolution

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HIV strains continuously evolve, tend to recombine and new circulating variants are being discovered. Novel strains complicate efforts to develop a vaccine against HIV and may exhibit higher transmission efficiency and virulence, and elevated resistance to antiretroviral agents. The United Nations Joint Programme on HIV/AIDS (UNAIDS) set an ambitious goal to end HIV as a public health threat by 2030 through comprehensive strategies that include epidemiological input as the first step of the process. In this context, molecular epidemiology becomes invaluable as it captures trends in HIV evolution rates that shape epidemiological pictures across several geographical areas. This review briefly summarizes the molecular epidemiology of HIV among people who inject drugs (PWID) in Europe and Asia. Following high transmission rates of subtype G and CRF14_BG among PWID in Portugal and Spain, two European countries, Greece and Romania, experienced recent HIV outbreaks in PWID that consisted of multiple transmission clusters including subtypes B, A, F1 and recombinants CRF14_BG and CRF35_AD. The latter was first identified in Afghanistan. Russia, Ukraine and other Former Soviet Union (FSU) states are still facing the devastating effects of epidemics in PWID produced by AFSU (also known as IDU-A), BFSU (known as IDU-B), and CRF03_AB. In Asia, CRF01_AE and subtype B (Western B and Thai B) travelled from PWID in Thailand to neighboring countries. Recombination hotspots in South China, Northern Myanmar, and Malaysia have been generating several intersubtype and inter-CRF recombinants (e.g. CRF07_BC, CRF08_BC, CRF33_01B etc.) increasing the complexity of HIV molecular patterns.

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Molecular Epidemiological Analysis ofenvandpolSequences in Newly Diagnosed HIV Type 1-Infected, Untreated Patients in Hungary

Cited by 15 publications

References 16 publications

Ten Years Survey of Primary HIV-1 Resistance in Serbia: The Occurrence of Multiclass Resistance

Ten Years Survey of Primary HIV-1 Resistance in Serbia: The Occurrence of Multiclass Resistance

Molecular epidemiology of HIV-1 infection in Europe: An overview

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

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