Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: Female–male comparisons

Albertini, Richard J.; Srám, Radim J.; Vacek, Pamela M.; Lynch, Jeremiah; Rössner, Pavel; Nicklas, Janice A.; McDonald, Jake; Boysen, Gunnar; Georgieva, Nadia I.; Swenberg, James A.

doi:10.1016/j.cbi.2006.07.004

Cited by 46 publications

(28 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports have documented chromosome damage in workers exposed to BD [1,27]. Tan considered that BD exposure would increase the frequency of MN [28]; however, these results were not supported by findings of a lack of increased genetic damage in 1,3-butadiene-exposed workers in studies conducted by Zhang [29].…”

Section: Discussionmentioning

confidence: 72%

“…In China, the annual production volume of BD was over 1.41 million tons in 2008, and was estimated to have reached nearly 2.77 million tons annually by 2012 [2]. BD exposure is a critical public health concern because of its carcinogenicity [1,3,4]. Epidemiological studies have shown that occupational exposure to BD is associated with increased mortality from leukemia [6][7][8] and other hematopoietic malignancies [5].…”

Section: Introductionmentioning

confidence: 99%

“…106-99-0), an important industrial chemical primarily used to manufacture synthetic rubbers, plastics, resins among other products. BD is also a ubiquitous environmental pollutant found in automobile exhaust, tobacco smoke, and factory fumes [1]. In China, the annual production volume of BD was over 1.41 million tons in 2008, and was estimated to have reached nearly 2.77 million tons annually by 2012 [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The association between genetic damage in peripheral blood lymphocytes and polymorphisms of three glutathione S-transferases in Chinese workers exposed to 1,3-butadiene

Cheng

Zhang

Zhao

et al. 2013

Mutation Research/Genetic Toxicology and Environmental Mutagene

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between genetic damage in peripheral blood lymphocytes and polymorphisms of three glutathione S-transferases in Chinese workers exposed to 1,3-butadiene

Cheng

Zhang

Zhao

et al. 2013

Mutation Research/Genetic Toxicology and Environmental Mutagene

View full text Add to dashboard Cite

“…Similar metabolites have been reported in cases of suspected chronic isobutane use [17]. Further experimental and case studies are needed to establish the forensic applications of butane metabolite detection, especially with respect to factors that influence the production and elimination of n-butane metabolites, such as metabolic enzymes [16], gender differences [18], and ethanol or drugs [19].…”

Section: Discussionmentioning

confidence: 82%

Quantitative determination of n-butane metabolites in three cases of butane sniffing death

Sasao

Yonemitsu

Ohtsu

et al. 2015

Forensic Science International

View full text Add to dashboard Cite

“…However, the most comprehensive studies of low BD exposure were negative with regard to HPRT gene mutation and cytogenetic response, although measured Hb adduct levels showed a significant increase with exposure (43,44). In these studies, neither the mutational nor the cytogenetic responses showed any association with genotypes.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Cancer Tests of 1,3-Butadiene Using Internal Dose, Genotoxic Potency, and a Multiplicative Risk Model

2008

View full text Add to dashboard Cite

In cancer tests with 1,3-butadiene (BD), the mouse is much more sensitive than the rat. This is considered to be related to the metabolism of BD to the epoxide metabolites, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane, and 1,2-epoxy-3,4-butanediol. This study evaluates whether the large difference in outcome in cancer tests with BD could be predicted quantitatively on the basis of the concentration over time in blood (AUC) of the epoxide metabolites, their mutagenic potency, and a multiplicative cancer risk model, which has earlier been used for ionizing radiation. Published data on hemoglobin adduct levels from inhalation experiments with BD were used for the estimation of the AUC of the epoxide metabolites in the cancer tests. The estimated AUC of the epoxides were then weighed together to a total genotoxic dose, by using the relative genotoxic potency of the respective epoxide inferred from in vitro hprt mutation assays using EB as standard. The tumor incidences predicted with the risk model on the basis of the total genotoxic dose correlated well with the earlier observed tumor incidences in the cancer tests. The total genotoxic dose that leads to a doubling of the tumor incidences was estimated to be the same in both species, 9 to 10 mmol/LÂh EB-equivalents. The study validates the applicability of the multiplicative cancer risk model to genotoxic chemicals. Furthermore, according to this evaluation, different epoxide metabolites are predominating cancer-initiating agents in the cancer tests with BD, the diepoxide in the mouse, and the monoepoxides in the rat.

show abstract

Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: Female–male comparisons

Cited by 46 publications

References 23 publications

The association between genetic damage in peripheral blood lymphocytes and polymorphisms of three glutathione S-transferases in Chinese workers exposed to 1,3-butadiene

The association between genetic damage in peripheral blood lymphocytes and polymorphisms of three glutathione S-transferases in Chinese workers exposed to 1,3-butadiene

Quantitative determination of n-butane metabolites in three cases of butane sniffing death

Evaluation of Cancer Tests of 1,3-Butadiene Using Internal Dose, Genotoxic Potency, and a Multiplicative Risk Model

Contact Info

Product

Resources

About