2019
DOI: 10.1007/5584_2019_402
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Molecular Epidemiology of Bordetella pertussis

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Cited by 23 publications
(18 citation statements)
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“…B. pertussis strains that are deficient in the production of the pertactin immunogen are prevalent in countries where only aP vaccines are used. In many of these countries the number of pertussis cases was increasing during the last decades ( 23 , 53 , 54 ).…”
Section: Discussionmentioning
confidence: 99%
“…B. pertussis strains that are deficient in the production of the pertactin immunogen are prevalent in countries where only aP vaccines are used. In many of these countries the number of pertussis cases was increasing during the last decades ( 23 , 53 , 54 ).…”
Section: Discussionmentioning
confidence: 99%
“…Beyond this, antigenic drift may potentiate reduced vaccine effectiveness and waning of Bp immunity, particularly in settings with widespread aP use [ 46 , 51 , 52 , 53 ]. Novel circulating Bp strains have evolved, containing mutations and/or deletions of key epitopes or antigens; this is secondary to pathogen adaptation to natural or, most likely, vaccine selection pressures, with subsequent pathogen escape [ 46 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, It is a limitation that the cases of ptxP3 strains were relative too small to give strong evidence about the protection against ptxP3 lineage by co-purified aPV. Furthermore, the ptxP3 with the pertactin (PRN) deficient isolates were widely appeared in some industries countries [25], whether the ptxP3 isolations in this study expressed of PRN were unknown in this study. Lastly, the age of the patients in our study was mainly the infant but not children after at least 5 years of vaccination of co-purified aPV.…”
Section: Discussionmentioning
confidence: 79%