Molecular epidemiology of bovine papillomatosis and the identification of a putative new virus type in Brazilian cattle

Batista, Marcus Vinícius de Aragão; Silva, M. A. R.; Pontes, Nayara Elis Cabral; Reis, Marcio C.; Corteggio, Annunziata; Castro, Roberto Soares de; Borzacchiello, Giuseppe; Balbino, Valdir Queiroz; Freitas, Antônio Carlos de

doi:10.1016/j.tvjl.2013.01.019

Cited by 35 publications

(49 citation statements)

References 32 publications

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“…Coinfections with two, three, and four BPV genotypes were determined in 46.9%, 28.1%, and 6.3% of cattle, respectively, whereas single infection was detected in 18.8%. Nevertheless, immunological failure might also have played a predisposing role in the dissemination of BPVs (6). In the present study, BLV was identified in three cattle with tumor-like lesions sampled from the same herd (13.0%), which causes immune suppression (18).…”

Section: Discussionmentioning

confidence: 55%

“…BPV-1 and BPV-2 have also been identified from equine sarcoids in horses as a result of interspecies transmission (2,3). The presence of BPV-2 DNA has been identified in alimentary fibropapillomas, cutaneous papillomas, and urinary bladder cancer (5,6). BPV types 1 and 2 have also been identified in peripheral blood leukocytes (7,8), and in different body fluids, such as milk, colostrum, and semen, obtained from animals with papillomatosis (5,9,10), and even from apparently healthy cattle (8,11) and horses (2,12).…”

Section: Introductionmentioning

confidence: 99%

“…BPV types 1 and 2 have also been identified in peripheral blood leukocytes (7,8), and in different body fluids, such as milk, colostrum, and semen, obtained from animals with papillomatosis (5,9,10), and even from apparently healthy cattle (8,11) and horses (2,12). BPV-4 is associated with cutaneous papillomatosis, besides upper-gastrointestinal papillomatosis (6,8,10). Furthermore, BPV-9 and BPV-10 have been identified in squamous epithelial papillomas of the udder, whereas BPV-3 and BPV-8 are responsible for cutaneous papillomas (6).…”

Section: Introductionmentioning

confidence: 99%

“…BPV-4 is associated with cutaneous papillomatosis, besides upper-gastrointestinal papillomatosis (6,8,10). Furthermore, BPV-9 and BPV-10 have been identified in squamous epithelial papillomas of the udder, whereas BPV-3 and BPV-8 are responsible for cutaneous papillomas (6).…”

Section: Introductionmentioning

confidence: 99%

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Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey

Ataseven¹,

Kanat²,

Ergün³

2016

Turk J Vet Anim Sci

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey

Ataseven¹,

Kanat²,

Ergün³

2016

Turk J Vet Anim Sci

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“…Although numerous BPV types have been described and putative and new BPV types have identified in Brazilian cattle from distinct regions [13,[15][16][17][18], Brazil is an extensive territory encompassing unstudied regions, which comprise a low number of habitants and one of the largest cattle herd worldwide. In this context, the Amazon region is propitious for the discovery of novel strains because this region has one of the largest beef cattle herds in Brazil and, in addition, the Amazon biome has one of the largest biodiversities worldwide.…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

et al. 2015

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Papillomaviruses are small and complex viruses that belong to the Papillomaviridae family, which comprises 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. Different genotypes of BPVs can cause distinct skin and mucosal lesions and the immunity they raise has low cross-protection. This report aimed to genotype BPVs in cattle from Northern Brazil based on nucleotide partial sequences of the L1 ORF. Skin wart samples from 39 bovines clinically and histopathologically diagnosed as cutaneous papillomatosis from Acre and Rondônia States were analyzed. The results revealed four already reported BPV types (BPVs 1, 2, 11, and 13), nine putative new BPV subtypes and four putative new BPV types as well as two putative new BPV types that were already reported. To our knowledge, this is the first record of BPVs from the Brazilian Amazon region that identified new possible BPV types and subtypes circulating in this population. These findings point to the great genetic diversity of BPVs that are present in this region and highlight the importance of this knowledge before further studies about vaccination are attempted.

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Genetic diversity of bovine papillomavirus types, including two putative new types, in teat warts from dairy cattle herds

et al. 2016

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Teat papillomatosis affects dairy cows worldwide. Milking can become difficult due to teat warts, and maintaining affected cows in the herds may diminish economic profit in the dairy industry. Currently, 13 bovine papillomavirus (BPV) types have been fully characterized, and numerous putative BPV types have been identified through partial L1 gene PCR. In order to identify the viral types present in warts on the udders of dairy cows, 40 teat lesions from 24 cows from 13 cattle farms in three States of Brazil were evaluated by PV L1 gene PCR. The warts that were evaluated contained sequences from BPVs 6-10, the putative BPV types BAPV9 and BAPV4, and two unreported putative papillomavirus (PV) types, named BPV/BR-UEL6 and BPV/BR-UEL7. In addition, mixed infections and coinfections were identified, since more than one lesion was observed on the udders of 13 cows. Phylogenetic analysis showed that BPV/BR-UEL6 is closely related to BPVs belonging to the genus Xipapillomavirus, while BPV/BR-UEL7 clustered with the previously reported strains Cervus timorensis and Pudu puda PVs, which represent a putative new PV type, and it was only distantly related to xi-, epsilon-, delta- and dyoxi-PVs. These results provide information that will assist in the understanding of the association of BPVs 6, 7, 8, 9, and 10, as well as putative BPV types BAPV4 and BAPV9, with mammary papillomatosis. This is the first characterization of putative novel PV types BPV/BR-UEL6 and BPV/BR-UEL7 in teat warts of dairy cows, highlighting the high genetic diversity of BPVs associated with teat papillomatosis.

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Molecular epidemiology of bovine papillomatosis and the identification of a putative new virus type in Brazilian cattle

Cited by 35 publications

References 32 publications

Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey

Molecular identification of bovine papillomaviruses in dairy and beef cattle: first description of Xi- and Epsilonpapillomavirus in Turkey

Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

Genetic diversity of bovine papillomavirus types, including two putative new types, in teat warts from dairy cattle herds

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