Molecular Epidemiology of Cancer

Abstract

Epidemiology is very successful in identifying environmental and lifestyle factors that increase or reduce risk of specific cancers, leading to cancer prevention strategies. However, the etiology of many types of cancer is still poorly understood, despite extensive use of questionnaires and interview-based approaches in conventional epidemiologic studies. The integration of molecular techniques into epidemiology studies may provide new insights and has been referred to as molecular epidemiology. For instance, our ability to make connections between lifestyle and cancer risk is limited by difficulty in accurately measuring exposure to many carcinogens-newer molecular markers of exposure may provide better information. The

The Analysis of Incidence of Risk Factors of Neoplastic Diseases among Patients with a Diagnosed Neoplastic Disease

“…Among Japanese inhabitants who consume the greatest quantities of rice a higher risk of colorectal cancer has been reported; a similar relation has been proved in Australia in case of high consumption of potatoes, while in American population, intake of higher number of snacks containing refined sugar correlated positively with a risk of cancer [26]. Among diet factors that may have an oncogenic effect, those that are perceived to be significant are high doses of nitrites and nitrates, salted foods, smoked and cured as well as too greasy or hot food [22][23][24]. When it comes to occurrence of overweight and obesity among respondents, 44% of women were overweight or obese, while when it comes to men 16%.…”

“…37% of men and 25% of women were exposed to plant protection chemicals Inadequate diet is considered to be one of the main causes of cancer. Due to civilization development, in the surrounding environment, also in food, there are numerous agents toxic for an organism that contain carcinogens [22][23][24]. Probably about 30% of all types of cancers depend on a diet, which means that nutritional factors have an influence on their development.…”

Bioinformatics challenges in molecular epidemiology of cancers

“…During the past decade, epidemiologic research has undergone major technological and methodological development, with incorporation of molecular, cellular, and other biologic measurements into traditional approach [2]. The etiology of cancers involves strong environmental and genetic components, in which the global distribution is characterized by a wide geographic variation in incidence.…”

Biologia molecular do câncer cervical

“…Coletivamente, essas duas classes de genes são responsáveis pela proliferação descontrolada, encontrada nos cânceres em humanos. 6,7 Quando ocorrem mutações, proto-oncogenes tornam-se oncogenes, que são carcinogênicos e causam multiplicação celular excessiva. Essas mutações levam o proto-oncogene a expressar em excesso sua proteína estimuladora do crescimento ou a produzir uma forma mais ativa.…”