Molecular Epidemiology of Classic, MLB, and VA Astroviruses in Children with Acute Gastroenteritis, 2014–2021: Emergence of MLB3 Strain in Japan

Okitsu, Shoko; Khamrin, Pattara; Hikita, Toshiyuki; Shimizu-Onda, Yuko; Thongprachum, Aksara; Hayakawa, Satoshi; Maneekarn, Niwat; Ushijima, Hiroshi

doi:10.1128/spectrum.00700-23

Cited by 3 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other works, it was found that human astrovirus causes 10% of acute gastroenteritis sporadic cases in children of <3 y, and that most outbreaks occurred mainly in healthcare and daycare centers, while in some developing countries, infection rates reached 20% [117]. The symptoms of gastrointestinal tract and inflammatory lesions affecting the meninges and brain tissue as encephalitis and meningitis were also reported [122,123]. The general and clinical characteristics of astrovirus are presented in Table 1.…”

Section: Astrovirusmentioning

confidence: 95%

Common and Potential Emerging Foodborne Viruses: A Comprehensive Review

Olaimat,

Taybeh,

Al-Nabulsi

et al. 2024

Life

View full text Add to dashboard Cite

Human viruses and viruses from animals can cause illnesses in humans after the consumption of contaminated food or water. Contamination may occur during preparation by infected food handlers, during food production because of unsuitably controlled working conditions, or following the consumption of animal-based foods contaminated by a zoonotic virus. This review discussed the recent information available on the general and clinical characteristics of viruses, viral foodborne outbreaks and control strategies to prevent the viral contamination of food products and water. Viruses are responsible for the greatest number of illnesses from outbreaks caused by food, and risk assessment experts regard them as a high food safety priority. This concern is well founded, since a significant increase in viral foodborne outbreaks has occurred over the past 20 years. Norovirus, hepatitis A and E viruses, rotavirus, astrovirus, adenovirus, and sapovirus are the major common viruses associated with water or foodborne illness outbreaks. It is also suspected that many human viruses including Aichi virus, Nipah virus, tick-borne encephalitis virus, H5N1 avian influenza viruses, and coronaviruses (SARS-CoV-1, SARS-CoV-2 and MERS-CoV) also have the potential to be transmitted via food products. It is evident that the adoption of strict hygienic food processing measures from farm to table is required to prevent viruses from contaminating our food.

show abstract

Section: Astrovirusmentioning

confidence: 95%

Common and Potential Emerging Foodborne Viruses: A Comprehensive Review

Olaimat,

Taybeh,

Al-Nabulsi

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

Human Astrovirus Infection and Outbreaks in Japanese Children Before and After the Emergence of COVID‐19 Pandemic

Ushijima,

Pham,

Nishimura

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

Human astroviruses (HAstVs) were examined in 1625 stool samples collected from outpatient children with diarrhea who visited clinics in 4–6 prefectures in Japan. The study was conducted over a period of 4 years from July 2018 to June 2022, spanning the period before and after the emergence of COVID‐19. The HAstV and other diarrheal viruses including group A rotavirus, norovirus and sapovirus were screened by RT‐PCR. Of these, HAstV was detected in 140 out of 1625 (8.6%). When the stool samples were categorized by the year of collection, HAstV was detected in 2018–2019, 2019–2020, 2020–2021, and 2021–2022 with the prevalences of 3.1%, 6.6%, 3.0%, and 20.1%, respectively. Among 140 HAstV positive cases, HAstV1, MLB1, MLB2, HAstV3, MLB3, and VA2 were detected in 77, 46, 10, 3, 2, and 2 samples, respectively. High infection rate was found in children 1–3 years of age (95/140; 67.9%). Severity of the disease increased with the co‐infection with norovirus. During the surveillance of 2021–2022, two outbreaks of HAstV were detected, one was an outbreak of HAstV1 and MLB2 in September, 2021 in Kyoto, the second was an outbreak of HAstV1 and MLB1 in December, 2021 in Kyoto and Shizuoka. It was interesting to observe that mixed‐infection of astroviruses between HAstV1 and MLB1 was reported for the first time in this study. Characterization of the subgenotypes in HAstV1 and HAstV3 indicated that most HAstV1 circulating in Japan belonged to HAstV1a and only a single strain was HAstV1b, whereas all HAstV3 was identified as the HAstV3c subgenotype. In conclusion, several HAstV genotypes, including classic HAstV, novel MLB, and VA genotypes, were detected in this study. The incidence of astrovirus outbreaks was also reported after the pandemic of COVID‐19 in 2021–2022.

show abstract

Precautionary findings on the utilization of FilmArray® to detect human astroviruses in fecal and sewage samples

Bae,

Takano,

Hoque

et al. 2024

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Molecular Epidemiology of Classic, MLB, and VA Astroviruses in Children with Acute Gastroenteritis, 2014–2021: Emergence of MLB3 Strain in Japan

Abstract: HAstVs are one of the pathogens of viral AGE and are considered the third most common viral agents of AGE after rotavirus and norovirus. HAstVs are also suspected to be the causative agents of encephalitis or meningitis in immunocompromised patients and elderly persons.

Cited by 3 publications

References 53 publications

Common and Potential Emerging Foodborne Viruses: A Comprehensive Review

Common and Potential Emerging Foodborne Viruses: A Comprehensive Review

Human Astrovirus Infection and Outbreaks in Japanese Children Before and After the Emergence of COVID‐19 Pandemic

Precautionary findings on the utilization of FilmArray® to detect human astroviruses in fecal and sewage samples

Contact Info

Product

Resources

About