Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15

Seki, Liliane Miyuki; Pereira, Polyana Silva; Conceição, Magda de Souza da; Souza, Maria José de; Marques, Elizabeth Andrade; Carballido, Jupira Miron; Carvalho, Maria Elisabeth Serqueira de; Carvalho-Assef, Ana Paula D’Alincourt; Asensi, Marise Dutra

doi:10.1016/j.bjid.2013.03.012

Cited by 40 publications

(30 citation statements)

References 29 publications

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“…In our study, ESBL production was detected in different genera, with an overall prevalence of 30.3% in the strains tested and the majority of positive isolates belonging to Enterobacter sp., Escherichia coli, and Klebsiella sp. Similar percentages were reported in other studies conducted by Seki et al (14) (40.2%), Lenhard-Vidal et al (15) (16) was conducted at the same hospital as the present study.…”

Section: Ethical Considerationssupporting

confidence: 92%

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

Rugini

Sobottka

Fuentefria

2015

Rev. Soc. Bras. Med. Trop.

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Section: Ethical Considerationssupporting

confidence: 92%

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

Rugini

Sobottka

Fuentefria

2015

Rev. Soc. Bras. Med. Trop.

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“…24 In Brazil, several studies have shown that CTX-M-15 is one of the most frequent ESBLs and is widely distributed in the country. 25 In Peru, limited investigations have included the molecular characteristics of Klebsiella, however, CTX-M-2 and CTX-M-15 were observed among commensal E. coli from healthy children in 2002. 26 This study has several limitations.…”

Section: Resultsmentioning

confidence: 99%

Molecular Characterization of Extended-Spectrum β-Lactamase-Producer Klebsiella pneumoniae Isolates Causing Neonatal Sepsis in Peru

García¹,

Astocondor²,

Rojo–Bezares³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Klebsiella pneumoniae (KP) is the most common cause of neonatal sepsis in the low-and middle-income countries. Our objective was to describe the phenotypic and molecular characteristics of extended-spectrum β-lactamase (ESBL)-producer KP in neonatal care centers from Peru. We collected 176 non-duplicate consecutive KP isolates from blood isolates of neonates from eight general public hospitals of Lima, Peru. The overall rate of ESBL production was 73.3% (N = 129). The resistance rates were higher among ESBL-producer isolates when compared with the nonproducers: 85.3% versus 12.8% for gentamicin (P < 0.01), 59.7% versus 8.5% for trimethoprim-sulfamethoxazole (P < 0.01), 45.0% versus 8.5% for ciprofloxacin (P < 0.01), and 36.4% versus 12.8% for amikacin (P < 0.01). A total of 359 β-lactamase-encoding genes were detected among 129 ESBL-producer isolates; 109 isolates (84.5%) carried two or more genes. Among 37 ESBL-producer isolates randomly selected, CTX-M-15 and CTX-M-2 were the most common ESBLs detected. Most of the isolates (92%) belonged to the group KpI. Pulsed-field gel electrophoresis showed that multiple KP clones were circulating among the eight neonatal units included.

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“…Isolates producing bla CTX-M-15 and bla SHV-11 have also been reported in Singapore (18). Furthermore, the coproduction of KPC-2 and CTX-M-15 has been described in K. pneumoniae ST437 (clonal complex 11) isolated from patients with bloodstream infections in Brazil (19).…”

mentioning

confidence: 95%

First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan

Saito

Takahashi

Sawabe

et al. 2014

Antimicrob Agents Chemother

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dWe investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene bla KPC-2 , which was present on the transferable plasmid of ca. 190 kb, in addition to the bla CTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-bla KPC-2 -ISKpn6-like), encompassing bla KPC-2 , were found to be similar to those of K. pneumoniae strains from China.

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Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15

Cited by 40 publications

References 29 publications

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

Occurrence and sensitivity profile of extended spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary hospital in Southern Brazil

Molecular Characterization of Extended-Spectrum β-Lactamase-Producer Klebsiella pneumoniae Isolates Causing Neonatal Sepsis in Peru

First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan

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