Molecular epidemiology of dengue virus serotypes 2 and 3 in Paraguay during 2001–2006: The association of viral clade introductions with shifting serotype dominance

Aquino, Jose Diaz; Tang, Weifeng; Ishii, Ryoichi; Ono, Takahiro; Eshita, Yuki; Aono, Hiroshi; Makino, Yoshihiro

doi:10.1016/j.virusres.2008.07.011

Cited by 28 publications

(32 citation statements)

References 30 publications

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“…Gross sequences of DENV-2 isolates from all epidemic periods grouped with sequences from DENV-2 American/Asian genotype; this finding was expected because this genotype is circulating in the Americas ( 6 , 7 ). Sequences of DENV-2 isolates from the 1998 epidemic grouped with sequences of DENV-2 isolates from the 1990 epidemic (data not shown) suggesting that viruses circulating during these 2 epidemic periods belong to the same lineage of the DENV-2 strain originally found in the state of Rio de Janeiro.…”

mentioning

confidence: 59%

Two Lineages of Dengue Virus Type 2, Brazil

Oliveira¹,

Araújo²,

Ferreira³

et al. 2010

Emerg. Infect. Dis.

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mentioning

confidence: 59%

Two Lineages of Dengue Virus Type 2, Brazil

Oliveira¹,

Araújo²,

Ferreira³

et al. 2010

Emerg. Infect. Dis.

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“…D3PY-26/06 and D3PY-28/06 were sampled in Asunción, the most severely affected location during the 2006–7 DENV-3 epidemics. The appearance of new DENV-2 and DENV-3 clades likely produced shifts of dominant serotype in Paraguay in 2005 and 2006), possibly causing the DENV-2 and DENV-3 epidemics in those years [48]. …”

Section: Resultsmentioning

confidence: 99%

Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends

et al. 2017

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Dengue, the predominant arthropod-borne viral disease affecting humans, is caused by one of four distinct serotypes (DENV-1, -2, -3 or -4). A literature analysis and review was undertaken to describe the molecular epidemiological trends in dengue disease and the knowledge generated in specific molecular topics in Latin America, including the Caribbean islands, from 2000 to 2013 in the context of regional trends in order to identify gaps in molecular epidemiological knowledge and future research needs. Searches of literature published between 1 January 2000 and 30 November 2013 were conducted using specific search strategies for each electronic database that was reviewed. A total of 396 relevant citations were identified, 57 of which fulfilled the inclusion criteria. All four dengue virus serotypes were present and co-circulated in many countries over the review period (with the predominance of individual serotypes varying by country and year). The number of countries in which more than one serotype circulated steadily increased during the period under review. Molecular epidemiology data were found for Argentina, Bolivia, Brazil, the Caribbean region, Colombia, Ecuador, Mexico and Central America, Paraguay, Peru and Venezuela. Distinct lineages with different dynamics were found in each country, with co-existence, extinction and replacement of lineages occurring over the review period. Despite some gaps in the literature limiting the possibility for comparison, our review has described the molecular epidemiological trends of dengue infection. However, several gaps in molecular epidemiological information across Latin America and the Caribbean were identified that provide avenues for future research; in particular, sequence determination of the dengue virus genome is important for more precise phylogenetic classification and correlation with clinical outcome and disease severity.

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“…34 Clade changes have also been associated with dengue severity. [35][36][37] However, there are no viral or immunological mechanisms that can be associated to the absence of major DHF epidemics in Brazil. Infection with DENV-1, followed by DENV-2 viruses, known to have circulated in Brazil, exactly reproduced the conditions that led to DHF in Cuba.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology of Dengue in the Americas Over the Last Three Decades: A Worrisome Reality

Martín¹,

Brathwaite²,

Zambrano³

et al. 2010

The American Society of Tropical Medicine and Hygiene

448

332

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Abstract. We have reported the epidemic patterns of dengue disease in the Region of the Americas from 1980 through 2007. Dengue cases reported to the Pan American Health Organization were analyzed from three periods: 1980-1989 (80s), 1990-1999 (90s), and 2000-2007 (2000-7). Age distribution data were examined from Brazil, Venezuela, Honduras, and Mexico. Cases increased over time: 1,033,417 (80s) to 2,725,405 (90s) to 4,759,007 (2000-7). The highest concentrations were reported in the Hispanic Caribbean (39.1%) in the 80s shifting to the Southern Cone in the 90s (55%) and 2000-7 (62.9%). From 1980 through 1987, 242 deaths were reported compared with 1,391 during 2000-7. The most frequently isolated serotypes were DENV-1 and DENV-2 (90s) and DENV-2 and DENV-3 (2000-7). The highest incidence was observed among adolescents and young adults; dengue hemorrhagic fever incidence was highest among infants in Venezuela. Increasing dengue morbidity/mortality was observed in the Americas in recent decades.

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Molecular epidemiology of dengue virus serotypes 2 and 3 in Paraguay during 2001–2006: The association of viral clade introductions with shifting serotype dominance

Cited by 28 publications

References 30 publications

Two Lineages of Dengue Virus Type 2, Brazil

Two Lineages of Dengue Virus Type 2, Brazil

Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends

The Epidemiology of Dengue in the Americas Over the Last Three Decades: A Worrisome Reality

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