Molecular epidemiology of gonorrhea

Sarafian, S. K.; Knapp, Joan S.

doi:10.1128/cmr.2.suppl.s49

Cited by 45 publications

(29 citation statements)

References 36 publications

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“…There has been little information on the genetic relatedness between gonococcal isolates, and most epidemiological studies have focused on auxotype and serotype data (Sarafian & Knapp, 1989). In this study 75% of the strains were represented by two auxotypes and the combination of auxotype and serovar revealed 79 different auxotype/ serovar classes, which provided less discrimination than MLEE.…”

Section: Consequences For Epidemiologymentioning

confidence: 70%

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Genetic structure of Neisseria gonorrhoeae populations: a non-clonal pathogen

O’Rourke

Stevens

1993

Journal of General Microbiology

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~~Reproduction by binary fission generates a clonal genetic structure in bacterial populations in the absence of a high rate of recombination. The extent of recombination in natural populations of Neisseria gonorrhoeae was determined from an analysis of electrophoretically demonstrable allelic variation at structural genes encoding nine enzyme loci in 227 worldwide isolates. No significant linkage disequilibrium was evident in the population, indicating that recombination must be frequent, relative to binary fission. The genetic structure of N. gonorrhoeae was compared with that of Bacillus subtilis from an earlier study. Linkage disequilibrium was less extreme in the N. gonorrhoeae population than in the local population of B. subtilis, in which only modest clonal structure was evident. Thus, N. gonorrhoeae, unlike pathogens so far examined, has a non-clonal population structure. As expected in a freely recombining population, no correlation was found between electrophoretic genotype and Serovar or auxotype.

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Section: Consequences For Epidemiologymentioning

confidence: 70%

“…Auxotyping and serovar determination have been accepted as the two major phenotypic systems for the typing of N . gonorrhoeae and the combination of both techniques has enabled temporal and geographic changes in gonococcal populations to be monitored (Sarafian & Knapp, 1989). Information on genetic variation in N .…”

Section: Introductionmentioning

confidence: 99%

Genetic structure of Neisseria gonorrhoeae populations: a non-clonal pathogen

O’Rourke

Stevens

1993

Journal of General Microbiology

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“…Temporal expansion and contraction of gonococcal auxotype/serovar classes are well described, as is the diversity that develops over time in closely related gonococcal subtypes (23). If a particular characteristic is associated with an individual gonococcal subtype, this feature may then become overrepresented in the total gonococcal population as that subtype expands and in turn be reduced in relevance as the overall proportion of that subtype declines.…”

Section: Discussionmentioning

confidence: 99%

“…Together, the A/S phenotypes NR/Bpyvut and NR/Bpyvt accounted for 94% of all PIP-negative gonococci, and most of the remaining PIP-negative strains were also of similar phenotypes, reflecting evolutionary changes of one or two epitopes responsible for the specific serotyping reactions of the gonococcus (6,23). The strain relatedness was confirmed in genotypic analyses performed elsewhere of a limited number of the isolates as part of an earlier collaborative study (Unemo et al, Abstr.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Appearance and Expansion of a Prolyliminopeptidase- Negative Subtype among Neisseria gonorrhoeae Isolates Collected in Sydney, Australia, from 2002 to 2005

et al. 2006

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Recent studies have demonstrated a wide geographic circulation of isolates of Neisseria gonorrhoeae that fail to produce prolyliminopeptidase (PIP). Tests based on the production of this enzyme are important elements of a number of identification systems for gonococci. We documented the appearance, expansion, and contraction of subtypes of 165 PIP-negative gonococci detected in an extended and systematic sample of the 3,926 N. gonorrhoeae isolates collected in Sydney, Australia, from July 2002 to September 2005. Their appearance, peak, and decline followed an "epidemic" curve. At the peak of their prevalence in 2003, PIP-negative gonococci comprised 22% of all isolates. Closely related phenotypes accounted for 162/165 of the PIP-negative gonococci. Algorithms for confirmation of N. gonorrhoeae should take account of the temporal and geographic variability of gonococci by utilizing two or more distinct confirmatory methods.

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“…As a result, gonococcal populations are made up of multiple, constantly evolving subtypes. Molecular-based studies [2][3][4] have shown that only small numbers of "successful" subtypes (usually specific to particular sexual networks) predominate and persist. A spread of multidrug-resistant gonococci occurs when these successful subtypes also acquire resistance genes.…”

mentioning

confidence: 99%

Multidrug-resistant Neisseria gonorrhoeae

Tapsall¹

2009

Canadian Medical Association Journal

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Molecular epidemiology of gonorrhea

Cited by 45 publications

References 36 publications

Genetic structure of Neisseria gonorrhoeae populations: a non-clonal pathogen

Genetic structure of Neisseria gonorrhoeae populations: a non-clonal pathogen

Dynamics of Appearance and Expansion of a Prolyliminopeptidase- Negative Subtype among Neisseria gonorrhoeae Isolates Collected in Sydney, Australia, from 2002 to 2005

Multidrug-resistant Neisseria gonorrhoeae

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