Molecular epidemiology of hepatitis B, hepatitis C, and HIV-1 co-infections in Ethiopia: Implications for disease burden and intervention strategies

Weldemariam, Atsbeha Gebreegziabxier; Lin, Su-I; Li, Wei-You; Wolday, Dawit; Yang, Ming-Hui; Alemu, Yibeltal Assefa; Sarusi, Deborah; Maayan, Shlomo; Chen, Yi-Ming Arthur; Chuang, Kuo-Pin; Tyan, Yu-Chang; Dai, Chia-Yen; Bezabeh, Asmamaw; Berhe, Rezene; Medhin, Girmay; Taddesse, Gizachew; Bane, Abate; Redae, Berhane; Zealiyas, Kidist; Gelibo, Terefe; Challa, Feyissa; Belay, Yohannes; Kassa, Desta; Bekele, Abebe; Gebremicael, Gebremedhin; Girma, Mulu; Getaneh, Yimam; Kidane, Eleni; Chalchisa, Dinkinesh; Adane, Sisay; Abdella, Saro; Tollera, Getachew; Hailu, Messay

doi:10.1016/j.actatropica.2024.107318

Acta Tropica

2024

DOI: 10.1016/j.actatropica.2024.107318

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Molecular epidemiology of hepatitis B, hepatitis C, and HIV-1 co-infections in Ethiopia: Implications for disease burden and intervention strategies

Atsbeha Gebreegziabxier Weldemariam,

Su-I Lin,

Wei-You Li

et al.

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2024

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Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances

Cheng,

Shan,

Wan

et al. 2024

World J Hepatol

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We focus on hepatitis B virus (HBV)-induced cirrhosis, global differences, and the evolution of antiviral treatment strategies. Chronic HBV (CHB) infection affects more than 250 million people globally, leading to cirrhosis and hepatocellular carcinoma. The aim of this article was to synthesize the current understanding of the pathophysiological mechanisms and clinical consequences of HBV-induced cirrhosis, and explore differences in disease progression between geographic regions. Disease progression varies across regions due to differences in HBV subtypes, transmission routes, and immune responses. The challenge of late diagnosis and treatment, particularly in resource-limited areas, highlights the urgency and importance of CHB service expansion. Modern nucleos(t)ide analogues, such as tenofovir and entecavir, have emerged as the main therapeutic regimens to improve clinical outcomes in patients by suppressing viral replication and attenuating liver fibrosis. However, drug resistance challenges highlight the need for ongoing research and personalized treatment strategies. This article highlights the mechanisms and impact of cirrhosis progression in the context of CHB infection, aiming to reduce the incidence of cirrhosis and its serious consequences, thereby improving the long-term health of CHB patients worldwide, especially in Africa.

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Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances

Cheng,

Shan,

Wan

et al. 2024

World J Hepatol

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Molecular epidemiology of hepatitis B, hepatitis C, and HIV-1 co-infections in Ethiopia: Implications for disease burden and intervention strategies

Cited by 1 publication

References 29 publications

Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances

Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances

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