Molecular epidemiology of hepatitis B and Delta virus strains that spread in the Mediterranean North East Coast of Tunisia

Yacoubi, Lamia; Brichler, Ségolène; Mansour, Waël; Gal, Frédéric Le; Hammami, Walid; Sadraoui, A.; Mami, N. Ben; Msaddek, Azouz; Cheikh, Imed; Triki, Henda; Gordien, Emmanuel

doi:10.1016/j.jcv.2015.10.002

Cited by 19 publications

(22 citation statements)

References 30 publications

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“…Recent results from Mustapha Hospital, testing over one thousand samples confirm this tendency (data not published). A low prevalence of HDV was also reported in the North‐East of Algeria (1.3%; 1/75), Tunisia and Libya . HDV is highly endemic in other regions like Mauritania and west of Turkey .…”

Section: Discussionmentioning

confidence: 89%

“…Eight genotypes of HDV (1‐8) have been described . The genotype 1 is ubiquitous and seems to be the unique genotype found in Mediterranean area, while genotypes 2 and 4 are rather localized in Southern and Eastern Asia. The genotype 3 is restricted to South America and the genotypes 5, 6, 7, and 8 have been isolated only in patients originating from Sub‐Saharan Africa.…”

Section: Discussionmentioning

confidence: 99%

“…This infection is intermediately endemic in Morocco and Tunisia, whereas it is highly endemic in Mauritania . Most of the HBV isolates from Tunisia and Morocco were classified as genotype D and the HBV/D7/D1 subgenotypes are predominant in these countries . In Mauritania, the genotype distribution appears more diverse including D, E and A, and subgenotyping revealed HBV/D1/D7, and the recently described/D8 .…”

Section: Introductionmentioning

confidence: 89%

“…19,21 Most of the HBV isolates from Tunisia and Morocco were classified as genotype D and the HBV/D7/D1 subgenotypes are predominant in these countries. 20,[22][23][24][25][26][27][28] In Mauritania, the genotype distribution appears more diverse including D, E and A, and subgenotyping revealed HBV/D1/D7, and the recently described/ D8. 29 While HDV infection is low endemic in Tunisia and Libya, 24,30,31 Mauritania is a highly endemic region for this virus, and HDV-1 is a predominant genotype.…”

Section: Introductionmentioning

confidence: 99%

“…20,[22][23][24][25][26][27][28] In Mauritania, the genotype distribution appears more diverse including D, E and A, and subgenotyping revealed HBV/D1/D7, and the recently described/ D8. 29 While HDV infection is low endemic in Tunisia and Libya, 24,30,31 Mauritania is a highly endemic region for this virus, and HDV-1 is a predominant genotype. 21,29,32 In Algeria, the prevalence of HBs antigen is 2.15% as determined by a national survey performed in 1998.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis B virus and hepatitis delta virus subtypes circulating in Algeria and seroprevalence of HDV infection

Gourari

Brichler

Gal

et al. 2018

Journal of Medical Virology

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hepatitis B virus and hepatitis delta virus subtypes circulating in Algeria and seroprevalence of HDV infection

Gourari

Brichler

Gal

et al. 2018

Journal of Medical Virology

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Molecular characterization of the full-length genome sequences of HDV strains circulating in Tunisia

et al. 2018

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While Tunisia is endemic for hepatitis B virus (HBV), a recent large-scale retrospective study, revealed a very low prevalence (2%) of hepatitis Delta virus (HDV) (Yacoubi et al. in J Clin Virol 72:126-132, 2015). All strains were classified within the genotype 1 (HDV-1) as assessed by nucleotide sequencing of the so-called 'R0' region of the genome described previously. In this study, we aimed to determine the full-length genome sequence of HDV isolates in order to fully characterize the HDV strains spreading in Tunisia. Eleven HDV antibody and RNA positive samples were obtained from the 1615 clinical samples previously studied. The whole genome sequence was obtained for 5 strains by sequencing and realignment of four overlapping regions covering the entire genome, followed by extensive phylogenetic analyses. Tunisian sequences segregated together with Turkish and African sequences and showed 60% GC content. Alignment with an HDV-1 consensus sequence revealed that they exhibited several point mutations in different functional domains of the delta proteins that, according to previous studies, might possibly affect their properties. In conclusion, the first full-length genome sequences of Tunisian HDV isolates are provided, isolates which are closely related to Turkish and Sub-Saharan Africa strains, supporting the hypothesis for the spread of HDV-1-strains from Africa via Tunisia to Turkey, before spread to the rest of the world.

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Prevalence of Hepatitis B virus and Hepatitis D virus Coinfection in Western Burkina Faso and molecular characterization of the detected virus strains

Sanou

Benkirane

Tinto

et al. 2018

International Journal of Infectious Diseases

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Molecular epidemiology of hepatitis B and Delta virus strains that spread in the Mediterranean North East Coast of Tunisia

Cited by 19 publications

References 30 publications

Hepatitis B virus and hepatitis delta virus subtypes circulating in Algeria and seroprevalence of HDV infection

Hepatitis B virus and hepatitis delta virus subtypes circulating in Algeria and seroprevalence of HDV infection

Molecular characterization of the full-length genome sequences of HDV strains circulating in Tunisia

Prevalence of Hepatitis B virus and Hepatitis D virus Coinfection in Western Burkina Faso and molecular characterization of the detected virus strains

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