Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in São Paulo State , Brazil: 2016 anticipated influenza season

Santos, Katia Corrêa de Oliveira; Silva, Daniela Bernardes Borges da; Sasaki, Norio Augusto; Benega, Margarete Aparecida; Garten, Rebecca; Paiva, Terezinha Maria de

doi:10.1590/s1678-9946201759009

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Among the 233 IAV+ cases across the surveillance sites, 111 NW or NP swabs were processed for sequencing. H1N1 was the predominant IAV subtype circulating globally [6, 17, 18] and in both Baltimore and Taipei ( Figure 1A and 1B ). One-hundred and three of the isolates (92.8%) were identified as H1N1 viruses and only 8 (7.2%) were H3N2 viruses.…”

Section: Resultsmentioning

confidence: 99%

Regional differences in vaccine uptake and serological responses to vaccine and circulating strains of H1N1 viruses among patients with confirmed influenza

Fink

Liu

Shaw‐Saliba

et al. 2020

Preprint

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Background. Seasonal epidemics of influenza are often characterized through national or international surveillance efforts to determine vaccine efficacy and vaccine strain selection, but they do not provide detailed information about local variations in factors that can influence influenza cases and disease severity. Methods. Surveillance for influenza like illness was performed in Emergency Medicine Departments in Taipei, Taiwan and Baltimore, Maryland during the winter of 2015-16. Detailed demographic and clinical data were obtained. Nasal swabs or washes were collected for influenza virus diagnosis, sequencing and isolation. Serum was collected to determine neutralizing antibody levels. Results. H1N1 viruses dominated both sites, but more influenza cases occurred in Taipei compared to Baltimore. H1 HA clade diversity was greater in Taipei. Vaccination rates were lower in Taipei than Baltimore, but vaccination was associated with an increase in serum neutralizing antibodies to recent H1N1 strains in Taipei, but not Baltimore. There was a higher level of preexisting immunity to circulating H1N1 strains in Baltimore. Conclusions. Regional differences in preexisting immunity and H1N1 strain circulation may have contributed to the vastly different 2015-16 influenza seasons in Taipei and Baltimore and suggest immune responses to vaccination can be affected by the degree of preexisting immunity in the population.

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Section: Resultsmentioning

confidence: 99%

Regional differences in vaccine uptake and serological responses to vaccine and circulating strains of H1N1 viruses among patients with confirmed influenza

Fink

Liu

Shaw‐Saliba

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, influenza surveillance in Russia, UK, eastern Europe, the Middle East and Asia (including Taiwan) had increasing numbers of severe cases ( Komissarov et al 2016 ; National Institute of Infectious Diseases Japan 2016 ; Pebody et al 2016 ; Newitt et al 2018 ; Public Health England (PHE) 2016 ; Taiwan CDC 2016 ; Tjon-Kon-Fat et al 2016 ). Reports also showed H1N1pdm impacted the southern hemisphere in the 2016 season, in particular, Brazil and Reunion Island ( Filleul et al 2016 ; Santos et al 2017 ; Cardoso et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Differential disease severity and whole-genome sequence analysis for human influenza A/H1N1pdm virus in 2015–2016 influenza season

et al. 2021

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During the 2015-16 winter, the US experienced a relatively mild influenza season compared to Taiwan which had a higher number of total and severe cases. While H1N1pdm viruses dominated global surveillance efforts that season, the global distribution of genetic variants and their contributions to disease severity have not been investigated. Samples collected from influenza A positive patients by the Johns Hopkins Center of Excellence for Influenza Research and Surveillance (JH-CEIRS) active surveillance in the emergency rooms in Baltimore, Maryland, USA and northern Taiwan between November 2015 and April 2016, were processed for influenza A virus whole genome sequencing. In Baltimore, the majority of the viruses were the H1N1pdm clade 6B.1 and no H1N1pdm clade 6B.2 viruses were detected. In northern Taiwan, more than half of the H1N1pdm viruses were clade 6B.1 and 38% were clade 6B.2, consistent with the global observation that most 6B.2 viruses circulated in Asia and not North America. Whole virus genome sequence analysis identified two genetic subgroups present in each of the 6B.1 and 6B.2 clades and one 6B.1 interclade reassortant virus. Clinical data showed 6B.2 patients had more disease symptoms including higher crude and inverse probability weighted odds of pneumonia than 6B.1 patients, suggesting 6B.2 circulation may be one of the reasons for the severe flu season in Taiwan. Local surveillance efforts linking H1N1pdm virus sequences to patient clinical and demographic data improve our understanding of influenza circulation and disease potential.

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“…Reports also showed H1N1pdm impacted the southern hemisphere in the 2016 season. In Sao Paulo State and a village in Brazil, an earlier influenza season with confirmed H1N1pdm 6B.1 as the dominant strain were reported [34, 35]. Reunion Island suffered the highest number of ICU hospitalization since 2009 and most were infected by H1N1pdm during April to August 2016 [36].…”

Section: Discussionmentioning

confidence: 99%

Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season

Liu

Gong

Shaw‐Saliba

et al. 2020

Preprint

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39During the 2015-16 winter, the US experienced a relatively mild influenza season compared to Taiwan 40 which had a large number of total and severe cases. While H1N1pdm viruses dominated global 41 surveillance efforts in this season, the global distribution of genetic variants and the contribution of 42 genetic to disease severity has not been investigated. Nasal samples collected from influenza A positive 43 patients by the Johns

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Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in São Paulo State , Brazil: 2016 anticipated influenza season

Cited by 10 publications

References 6 publications

Regional differences in vaccine uptake and serological responses to vaccine and circulating strains of H1N1 viruses among patients with confirmed influenza

Regional differences in vaccine uptake and serological responses to vaccine and circulating strains of H1N1 viruses among patients with confirmed influenza

Differential disease severity and whole-genome sequence analysis for human influenza A/H1N1pdm virus in 2015–2016 influenza season

Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season

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