Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006–2013

Cho, Han-Gil; Lee, Sung-Geun; Kim, Jueun; Yu, Kyeong-Sin; Lee, Deog‐Yong; Park, Po-Hyun; Yoon, Mi‐Hye; Jho, Eek‐hoon; Kim, Jae Hong; Paik, Soon-Young

doi:10.1016/j.jcv.2014.08.018

Cited by 20 publications

(14 citation statements)

References 32 publications

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“…In addition, from January 2010 to December 2013, only 10 specimens were positive for the presence of Genogroup I NoV by real time RT PCR (data not shown). Most genogroup II NoV strains detected in this study belonged to the genotypes GII.4 and GII.3 (53.3% and 17.9%, respectively), which were the most prevalent strains globally in children with sporadic acute gastroenteritis [Siebenga et al, ; Boon et al, ; Cho et al, ; Yu et al, ]. GII.4‐2006b was the most predominant NoV variant from 2010 to 2012, which was rapidly replaced by Sydney‐2012 variant in 2013, consistent with the worldwide epidemic [Eden et al, ; van Beek et al, ; Allen et al, ].…”

Section: Discussionsupporting

confidence: 77%

Molecular epidemiology of genogroup II norovirus infection among hospitalized children with acute gastroenteritis in Suzhou (Jiangsu, China) from 2010 to 2013

Zhang³

et al. 2015

Journal of Medical Virology

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Noroviruses (NoVs) are the most common cause of acute gastroenteritis in both sporadic and outbreak cases. Genotyping and recombination analyses were performed in order to help getting more knowledge of the distribution and genetic diversity of NoVs in Suzhou, located in Jiangsu province of China. All stool samples were collected from hospitalized children younger than 5 years old with acute gastroenteritis. For genotyping, the open reading frame (ORF) 1 and ORF2 were partially amplified and sequenced. 26.9% of stool samples were positive for genogroup II NoVs. The most common genotype was GII.4 and its variants included Den Haag-2006b, New Orleans-2009, and Sydney-2012. The Den Haag-2006b variants predominated during 2010-2012. In 2013, it was replaced by the Sydney-2012 variant. The second most common genotype was GII.12/GII.3. NoVs could be detected throughout the year, with GII.4 and GII.12/GII.3 coexisting during the cold months, and GII.4 was the main genotype during the warm months. The highest prevalence of NoV was detected in young children aged <24 months. Patients infected with GII.4 had a higher chance of getting moderate fever than other NoV-positive patients, while those infected with GII.12/GII.3 tended to have a mild degree of fever. NoV is an important pathogen responsible for viral gastroenteritis among children in Suzhou. Analyses of NoV circulating between 2010 and 2013 revealed a change of predominant variant of NoV GII.4 in each epidemic season and intergenotype recombinant strains represented an important part.

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Section: Discussionsupporting

confidence: 77%

Molecular epidemiology of genogroup II norovirus infection among hospitalized children with acute gastroenteritis in Suzhou (Jiangsu, China) from 2010 to 2013

Zhang³

et al. 2015

Journal of Medical Virology

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“…The GII.4-2009 variant was first detected in January 2010 and was predominant in 2011-2012. However, it was rapidly displaced by the GII.4-2012 variant, which emerged in May 2012 and circulated substantially in 2012-2013 (45) . According to a recent study, GII-2006b variants were still co-circulating with 2012 variants in November 2012 and June 2013 in South Korea (46) .…”

Section: Emergence Of Nov Gii-4 Variantsmentioning

confidence: 99%

Molecular epidemiology of norovirus in South Korea

Lee¹,

Cho²,

Paik³

2015

BMB Reports

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Norovirus is a major cause of viral gastroenteritis and a common cause of foodborne and waterborne outbreaks. Norovirus outbreaks are responsible for economic losses, most notably to the public health and food industry field. Norovirus has characteristics such as low infectious dose, prolonged shedding period, strong stability, great diversity, and frequent genome mutations. Besides these characteristics, they are known for rapid and extensive spread in closed settings such as hospitals, hotels, and schools. Norovirus is well known as a major agent of food-poisoning in diverse settings in South Korea. For these reasons, nationwide surveillance for norovirus is active in both clinical and environmental settings in South Korea. Recent studies have reported the emergence of variants and novel recombinants of norovirus. In this review, we summarized studies on the molecular epidemiology and nationwide surveillance of norovirus in South Korea. This review will provide information for vaccine development and prediction of new emerging variants of norovirus in South Korea. [BMB Reports 2015; 48(2): 61-67]

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“…GI, II, and IV are known to infect humans, and GII.4, which undergoes rapid antigenic variation, is the most predominant genotype worldwide [1]. This genotype has also been reported to cause both sporadic cases and outbreaks and was detected in humans and the environment in Korea [2,3]. However, several recent outbreaks have been attributed to GII.17, and the prevalence of this genotype in both outbreaks and sporadic cases has increased sharply in Korea [4].…”

Section: Introductionmentioning

confidence: 99%

Emergence of Norovirus GII.17-associated Outbreak and Sporadic Cases in Korea from 2014 to 2015

Jung

Hwang

Jung

et al. 2017

Osong Public Health Res Perspect

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Human norovirus are major causative agent of nonbacterial acute gastroenteritis. In general, genogroup (G) II.4 is the most prominent major genotype that circulate in human population and the environment. However, a shift in genotypic trends was observed in Korea in December 2014. In this study, we investigated the trend of norovirus genotype in detail using the database of Acute Diarrhea Laboratory Surveillance (K-EnterNet) in Korea. GII.17 has since become a major contributor to outbreaks of norovirus-related infections and sporadic cases in Korea, although the reason for this shift remain unknown.

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Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006–2013

Cited by 20 publications

References 32 publications

Molecular epidemiology of genogroup II norovirus infection among hospitalized children with acute gastroenteritis in Suzhou (Jiangsu, China) from 2010 to 2013

Molecular epidemiology of genogroup II norovirus infection among hospitalized children with acute gastroenteritis in Suzhou (Jiangsu, China) from 2010 to 2013

Molecular epidemiology of norovirus in South Korea

Emergence of Norovirus GII.17-associated Outbreak and Sporadic Cases in Korea from 2014 to 2015

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