Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010

Wang, Yuanhong; Zhou, Dun-Jin; Zhou, Xuan; Yang, Ting; Ghosh, Souvik; Pang, Bei-Bei; Peng, Jinsong; Liu, Man‐Qing; Hu, Qinxue; Kobayashi, Nobumichi

doi:10.1007/s00705-012-1437-1

Cited by 41 publications

(41 citation statements)

References 34 publications

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“…A GII.P4 New Orleans-GII.4 Sydney virus which has been reported by others (36-39) also caused 1.1% of all outbreaks. The majority of the GII.3 viruses had either a GII.P12 or GII.P21 (formerly GII.Pb) polymerase, as has been described previously (15,(40)(41)(42), but GII.P16-GII.3 viruses were also found. GII.2 viruses were primarily associated with a GII.P2 polymerase, but GII.Pe-GII.2 and GII.P16-GII.2 were also detected.…”

Section: Discussionsupporting

confidence: 78%

“…GII.2, GII.3, GII.10, GII.12, GII.13, and GII.17 viruses are known to harbor GII.P16 polymerases. GII.P16-GII.2 viruses reported previously in China, Japan, and Australia/ New Zealand (16,40,45,46) are genetically distinct from the recently emerging GII.P16-GII.2 viruses that caused a sharp increase in the number of norovirus infections in Germany and China in late 2016 (47,48). This novel GII.P16-GII.2 recombinant virus caused at least seven outbreaks in the United States in 2016 as early as August.…”

Section: Discussionmentioning

confidence: 78%

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Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses

et al. 2017

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Noroviruses are the most frequent cause of epidemic acute gastroenteritis in the United States. Between September 2013 and August 2016, 2,715 genotyped norovirus outbreaks were submitted to CaliciNet. GII.4 Sydney viruses caused 58% of the outbreaks during these years. A GII.4 Sydney virus with a novel GII.P16 polymerase emerged in November 2015, causing 60% of all GII.4 outbreaks in the 2015-2016 season. Several genotypes detected were associated with more than one polymerase type, including GI.3, GII.2, GII.3, GII.4 Sydney, GII.13, and GII.17, four of which harbored GII.P16 polymerases. GII.P16 polymerase sequences associated with GII.2 and GII.4 Sydney viruses were nearly identical, suggesting common ancestry. Other common genotypes, each causing 5 to 17% of outbreaks in a season, included GI.3, GI.5, GII.2, GII.3, GII.6, GII.13, and GII.17 Kawasaki 308. Acquisition of alternative RNA polymerases by recombination is an important mechanism for norovirus evolution and a phenomenon that was shown to occur more frequently than previously recognized in the United States. Continued molecular surveillance of noroviruses, including typing of both polymerase and capsid genes, is important for monitoring emerging strains in our continued efforts to reduce the overall burden of norovirus disease.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 78%

Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses

et al. 2017

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“…Noroviruses are divided into six genogroups (GI-GVI) and human strains are grouped into GI, GII, and GIV (12,30). Noroviruses are indirectly transmitted to humans from contaminated food and water sources and can also be transmitted directly from person to person (31,32).…”

Section: Discussionmentioning

confidence: 99%

Frequency and molecular characterization of human norovirus in Erzurum, Turkey

Timurkan¹,

Aydın²,

Aktaş³

2017

Turk J Med Sci

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Background/aim: There are limited studies on genotyping and phylogenetic analysis of norovirus in Turkey, and this has not previously been studied in the Eastern Anatolia region. The aim of the present study was to determine the norovirus profile in this region with genotyping and phylogenetic analysis. Materials and methods:Included in the study were stool samples obtained from 427 people from different age groups in Eastern Anatolia. The nucleic acid samples isolated by the automatic system and nucleic acid sequence reactions and phylogenetic analyses were performed on RNA samples. Results:The presence of norovirus was detected in 86 (20.1%) of the 427 stool samples by RT-PCR analysis. Twenty-six samples selected randomly from norovirus-RNA positive samples were subjected to the sequence reaction. In 24 of the 26 samples, genogroup GII was determined, as well as one each from GI and GIV in sequence reactions. Four different genotypes were detected in genogroup GII, which were determined to be the dominant types. These were GII.1, GII.4, GII.16, and GII.21. The GI.6 and GIV.1 genotypes were determined in genogroups GI and GIV, respectively. Conclusion:The high frequency and genetic diversity of these infections are risk factors for disease and so vaccine studies should be undertaken in consideration of this situation.

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“…During the past several years, most studies of NoV infection in China focused on the role of human NoV in acute gastroenteritis in children [9, 11, 42]. Although recent studies of NoV infection have focused on adults, no detailed examination of the genotype distribution among various age groups and according to season has been published [7, 12, 33, 38]. The present study was carried out to investigate the prevalence and genetic diversity of NoVs in adults with acute gastroenteritis in Huzhou, a medium-sized city located in eastern China.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genetic diversity of noroviruses in adults with acute gastroenteritis in Huzhou, China, 2013–2014

Han

Chen

et al. 2015

Arch Virol

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Norovirus (NoV) infection is the most common cause of nonbacterial acute gastroenteritis, which affects both adults and children. However, the molecular epidemiology of NoV in adults with acute gastroenteritis in China has not been investigated extensively. In this study, we investigated the occurrence of NoV infections and analyzed the genetic diversity of NoV in adults with acute gastroenteritis in Huzhou, China. A total of 796 fecal samples were collected from outpatients (≥16 years of age) between March 2013 and February 2014. Real-time RT-PCR was performed to detect NoV genogroups I (GI) and II (GII). For genotyping, the capsid and RNA-dependent RNA polymerase (RdRp) genes were partially amplified and sequenced for phylogenetic analysis. NoVs were detected in 26.51 % (211/796) of the specimens, with GII being predominant, representing 96.20 % of the NoV infections. At least nine genotypes were identified among GI and GII specimens, including GI.P2/GI.2, GI.P3/GI.3, GI.P4/GI.4, GII.Pe/GII.4 Sydney_2012, GII.P12/GII.3, GII.P7/GII.6, GII.P16/GII.13, GII.Pe, and GII.Pg (RdRp only). This is the first report of a GII.P16/GII.13 recombinant virus in adults in China. GII.Pe/GII.4 Sydney_2012 was the most prevalent genotype and the only GII.4 variant identified during the study period. Our findings suggested that NoV was a common causative agent of acute gastroenteritis in adults in Huzhou, China. During the study period, the NoVs circulating in adults in Huzhou were predominantly GII.4 Sydney_2012 variants and GII NoV recombinants.

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Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010

Cited by 41 publications

References 34 publications

Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses

Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses

Frequency and molecular characterization of human norovirus in Erzurum, Turkey

Prevalence and genetic diversity of noroviruses in adults with acute gastroenteritis in Huzhou, China, 2013–2014

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