Molecular epidemiology of plasmid-mediated high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus in four Spanish health care settings

Pérez-Roth, Eduardo; Potel, Carmen; Espartero, Xiomara; Constela-Caramés, Lucia; Méndez-Álvarez, Sebastián; Álvarez-Fernández, Maximiliano

doi:10.1016/j.ijmm.2013.03.003

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…Regarding to CC5 which was found in 12 strains, this clonal lineage is mainly found in Spanish hospitals Pérez-Roth et al, 2013). The lineage CC5 is characterized by ciprofloxacin, tobramycin/kanamycin and erythromycin resistance , which is in accordance with our results.…”

Section: Discussionsupporting

confidence: 91%

Characterization of tetracycline and methicillin resistant Staphylococcus aureus strains in a Spanish hospital: Is livestock-contact a risk factor in infections caused by MRSA CC398?

Benito

Lozano

Rezusta

et al. 2014

International Journal of Medical Microbiology

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Section: Discussionsupporting

confidence: 91%

Characterization of tetracycline and methicillin resistant Staphylococcus aureus strains in a Spanish hospital: Is livestock-contact a risk factor in infections caused by MRSA CC398?

Benito

Lozano

Rezusta

et al. 2014

International Journal of Medical Microbiology

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“…This gene encodes a novel isoleucyl-tRNA synthetase (88,89) and is primarily disseminated via plasmid-mediated horizontal gene transfer (74). A range of conjugative plasmids have been reported to harbor mupA, predominantly those related to the pSK1/pG01 family of plasmids (90)(91)(92)(93). Moreover, within plasmids, mupA can be flanked by insertion sequences (IS), particularly IS257, which may promote recombination-mediated dissemination of mupA between plasmids (92,94,95).…”

Section: Currently Used Topical Antibacterial Agents Mupirocinmentioning

confidence: 99%

Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns

2017

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Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Challenges involved in the use of topical antimicrobials include increasing rates of bacterial resistance, local hypersensitivity reactions (particularly to older agents, such as bacitracin), and concerns about the indiscriminate use of antiseptics potentially coselecting for antibiotic resistance. We review the evidence for the major clinical uses of topical antibiotics and antiseptics. In addition, we review the mechanisms of action of common topical agents and define the clinical and molecular epidemiology of antimicrobial resistance in these agents. Moreover, we review the potential use of newer and emerging agents, such as retapamulin and ebselen, and discuss the role of antiseptic agents in preventing bacterial skin infections. A comprehensive understanding of the clinical efficacy and drivers of resistance to topical agents will inform the optimal use of these agents to preserve their activity in the future.

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“…They often confer resistance to other antibiotics such as neomycin, tobramycin and kanamycin (due to the integration of pUB110 plasmids that harbor the aadD gene), antiseptics (due to the presence of qac genes) (130), and eventually trimethoprim (mediated by Tn4001), penicillins (due to the presence of Tn552::blaZ), and others. Plasmids of this group may also confer resistance to mupirocin (131)(132)(133) and vancomycin (134,135), represented by pUSA03 (which harbors ileS and tetK) and pWL1043 (which contains Tn1546, Tn4001, Tn4002, Tn552, and qacC). The pSK41-like plasmids are able to mobilize other plasmids present in the same bacterial cell (133,136,137).…”

Section: Repa_n Staphylococcal Plasmids (Fig 5)mentioning

confidence: 99%

The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials

et al. 2015

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The phylum Firmicutes is one of the most abundant groups of prokaryotes in the microbiota of humans and animals and includes genera of outstanding relevance in biomedicine, health care, and industry. Antimicrobial drug resistance is now considered a global health security challenge of the 21st century, and this heterogeneous group of microorganisms represents a significant part of this public health issue.

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Molecular epidemiology of plasmid-mediated high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus in four Spanish health care settings

Cited by 13 publications

References 15 publications

Characterization of tetracycline and methicillin resistant Staphylococcus aureus strains in a Spanish hospital: Is livestock-contact a risk factor in infections caused by MRSA CC398?

Characterization of tetracycline and methicillin resistant Staphylococcus aureus strains in a Spanish hospital: Is livestock-contact a risk factor in infections caused by MRSA CC398?

Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns

The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials

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