Molecular Epidemiology of Porcine Circovirus Type 3 Infection in Swine Herds in China

Li, Xiangdong; Zhang, Chaolin; Qiao, Mu; Guo, Jiangsong; Xing, Guangyuan; Jin, Chunxia; Wang, Juan; Sun, Ming; Tian, Kegong

doi:10.1007/s12250-018-0041-2

Cited by 10 publications

(13 citation statements)

References 15 publications

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“…PCV3 has been detected in various tissue samples with varying positive rates [ 15 , 34 – 38 ]. Our findings are in agreement with reports from Fan et al .…”

Section: Discussionmentioning

confidence: 99%

“…(2018) and Li et al . (2018), that PCV3 mainly infect lungs and lymphoid tissues such as lymph nodes and tonsil [ 34 , 35 , 38 ]. PCV2 is known to have tropism for lymphoid tissues in pigs, with lymphoid depletion and histiocytic replacement of lymphoid tissues being hallmark lesions of PCV2 infection [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tests of Neutrality [34,35,38]. PCV2 is known to have tropism for lymphoid tissues in pigs, with lymphoid depletion and histiocytic replacement of lymphoid tissues being hallmark lesions of PCV2 infection https://doi.org/10.1371/journal.pone.0235832.g005 PLOS ONE [39,40].…”

Section: Gene Sequencementioning

confidence: 99%

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First molecular detection and complete sequence analysis of porcine circovirus type 3 (PCV3) in Peninsular Malaysia

et al. 2020

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Porcine circovirus type 3 (PCV3) is a newly emerging virus in the swine industry, first reported recently in 2016. PCV3 assembles into a 2000 bp circular genome; slightly larger than PCV1 (1758-1760 bp), PCV2 (1766-1769 bp) and PCV4 (1770 bp). Apart from being associated with porcine dermatitis and nephropathy syndrome (PDNS), PCV3 has been isolated from pigs with clinical signs of reproductive failures, myocarditis, porcine respiratory disease complex (PRDC) and neurologic disease. Given that PCV3 is increasingly reported in countries including Thailand and U.S. with whom Malaysia shares trade and geographical relationship; and that PCV3 is associated with several clinical presentations that affect productivity, there is a need to study the presence and molecular characteristics of PCV3 in Malaysian swine farms. Twenty-four commercial swine farms, three abattoirs and retail shops in Peninsular Malaysia were sampled using convenience sampling method. A total of 281 samples from 141 pigs, including 49 lung archive samples were tested for PCV3 by conventional PCR. Twenty-eight lung samples from wild boar population in Peninsular Malaysia were also included. Nucleotide sequences were analyzed for maximum likelihood phylogeny relationship and pairwise distances. Results revealed that PCV3 is present in Peninsular Malaysia at a molecular prevalence of 17.02%, with inguinal lymph nodes and lungs showing the highest molecular detection rates of 81.82% and 71.43% respectively. Despite wide reports of PCV3 in healthy animals and wild boars, no positive samples were detected in clinically healthy finishers and wild boar population of this study. PCV3 strain A1 and A2 were present in Malaysia, and Malaysian PCV3 strains were found to be phylogenetically related to Spanish, U.S. and Mexico strains.

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“…PCV3 has been detected in various tissue samples with varying positive rates [ 15 , 34 – 38 ]. Our findings are in agreement with reports from Fan et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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First molecular detection and complete sequence analysis of porcine circovirus type 3 (PCV3) in Peninsular Malaysia

et al. 2020

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“…The genetic and traceability analyses of PCV3 epidemic strains are of great significance for preventing and controlling this infectious disease (17,18,22). In this study, the nucleotide sequences of the cap gene from nine strains of PCV3 in Xinjiang shared high identities with other strains from China and abroad.…”

Section: Discussionmentioning

confidence: 81%

“…Due to the widespread use of commercial vaccines in Chinese pig herds, PCV2 infection has been controlled to some extent (31). However, since PCV3 was first discovered in 2016, PCV3 infection has occurred on pig farms in more than 10 provinces including Jiangxi, Hubei, Henan, Chongqing, Fujian, Guangdong, Hunan, and Jiangsu, causing great damage to the Chinese pig industry (3,16,18,19,24,27). Some studies showed that PCV3 infection was associated with abortion, respiratory failure, and diarrhoea in weaned piglets (10,31); however, the pathogenesis of PCV3 was still unclear (5,13).…”

Section: Discussionmentioning

confidence: 99%

Molecular detection and genetic diversity of porcine circovirus type 3 in commercial pig farms in Xinjiang province, China

Qiao

Wang

Zhang

et al. 2019

Journal of Veterinary Research

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IntroductionPorcine circovirus type 3 (PCV3) is a newly discovered porcine circovirus. The molecular characteristics and genetic evolution of PCV3 in Xinjiang province, China still being unclear, the aim of the study was their elucidation.Material and MethodsA total of 393 clinical samples were collected from pigs on commercial farms in nine different regions of Xinjiang and phylogenetic analysis based on full-length Cap genes was performed.ResultsThe prevalence at farm level was 100%, while in all the tested samples it was 22.39%. Nine PCV3 strains were detected in Xinjiang province and they shared 98.9–99.3% nucleotide and 97.5–100.0% Cap gene amino acid sequence identities with other epidemic strains from China and abroad. Compared with other epidemic strains of PCV3, there were 26 base mutation sites in the Cap gene in the nine Xinjiang strains, resulting in the mutation of amino acids at positions 20, 24, 75, 77, 108, 111 and 206. Phylogenetic analysis showed that these strains can be divided into two different genetic groups, to the first of which five strains affiliated and divided between subgroups 1.1 and 1.2, and to the second of which the other four strains affiliated and similarly divided between subgroups 2.1 and 2.2.ConclusionPCV3 circulates widely among commercial pig farms in Xinjiang province, China, and displays obvious genetic diversity. The results provide epidemiological information useful for the prevention and control of PCV3 infection in the pig industry.

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Establishment and characterization of the pig tonsil epithelial (PT) cell line as a new model for persist infection of Japanese Encephalitis Virus

Liu

Xiao

et al. 2020

Veterinary Microbiology

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Molecular Epidemiology of Porcine Circovirus Type 3 Infection in Swine Herds in China

Cited by 10 publications

References 15 publications

First molecular detection and complete sequence analysis of porcine circovirus type 3 (PCV3) in Peninsular Malaysia

First molecular detection and complete sequence analysis of porcine circovirus type 3 (PCV3) in Peninsular Malaysia

Molecular detection and genetic diversity of porcine circovirus type 3 in commercial pig farms in Xinjiang province, China

Establishment and characterization of the pig tonsil epithelial (PT) cell line as a new model for persist infection of Japanese Encephalitis Virus

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