Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL)

Souza, Marilen Queiroz de; Teotônio, Isabella Márcia Soares Nogueira; Almeida, Fernanda Coutinho de; Heyn, Gabriella Simões; Alves, Priscilla Souza; Romeiro, Luiz Antônio Soares; Pratesi, Riccardo; Nóbrega, Yanna Karla de Medeiros; Pratesi, C

doi:10.1186/s12906-018-2247-0

Cited by 26 publications

(33 citation statements)

References 36 publications

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“…Cashew nut shell phenolics are used in traditional medicine as anti-inflammatory, antidiarrheal, anti-asthmatic and depurative agents. Previous studies have confirmed their biological properties, including antibacterial, anti-inflammatory, antiproliferative, antioxidant and enzymatic inhibitory activities (de Sousa Leite et al, 2016;de Souza et al, 2018). Chen et al (2005) reported on the extracted almond skin flavonoids and demonstrated their antioxidant capacity in vitro.…”

Section: Health Benefits Of Phenolic Compoundsmentioning

confidence: 80%

Phenolic compounds in agri-food by-products, their bioavailability and health effects

Shahidi¹,

Varatharajan²,

Oh³

et al. 2019

Journal of Food Bioactives

111

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Phenolic compounds constitute a large and diverse group of secondary metabolites derived from phenylalanine and tyrosine and are widely distributed throughout the plant kingdom. They could be divided into different classes such as simple phenol, phenyl acetic acid, hydroxybenzoic acid, hydroxycinnamic acid, and other phenylpropanoids as well as condensed tannins (proanthocyanidins) and hydrolysable tannins, among others, depending on their basic carbon skeleton structure. Phenolic compounds in plant-based foods have been suggested to have a number of beneficial health effects including prevention of cancer, cardiovascular disease, diabetes, immune disorders, neurogenerative disease and others. These properties are largely attributable to the antioxidant activity of the phenolic compounds as well as other mechanisms of action. Therefore, nutraceuticals of plant origin may evolve to be considered a vital aspect of dietary-disease preventive food components. Agri-food industries generate substantial quantities of phenolic rich by-products, which could serve as an attractive and commercially viable source of nutraceuticals. This contribution mainly summarizes the occurrence of phenolic compounds and some other bioactives in various Agri-food by-products, their bioavailability and health benefits.

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Section: Health Benefits Of Phenolic Compoundsmentioning

confidence: 80%

Phenolic compounds in agri-food by-products, their bioavailability and health effects

Shahidi¹,

Varatharajan²,

Oh³

et al. 2019

Journal of Food Bioactives

111

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show abstract

“…The cashew nuts contain phenolic compounds with antioxidant activity [19,44] and can be used to treat the incidence of chronic and degenerative diseases, including cancer, cardiovascular and neurodegenerative diseases [39]. CNSLs have been also reported for many other diverse pharmacological effects such as insecticidal [13], larvicidal and antiacetylcholinesterase [7,34], anti-inflammatory [8], antioxidant [3], anxiolytic [14], antibacterial [27], and so on. In a recent study, it has been reported that the CNSLs may impart genotoxic effects in prokaryotic and eukaryotic systems [24].…”

Section: Introductionmentioning

confidence: 99%

Cytogenotoxic and mutagenic profiling of cashew nut shell liquids and cardanol

et al. 2019

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Background: Cashew and its compounds have many important biological effects. This study is aimed at evaluating genotoxic and mutagenic effects of natural cashew nut shell liquid (nCNSL) and industrial cashew nut shell liquid (iCNSL) and a major component of iCNSL called Cardanol. Methods: Test samples were undergone for comet assay and micronucleus tests in Swiss albino mice. Animals were orally treated with 17.37, 34.75 and 69.5 mg/kg of the test substances taking distilled water (10 mL/kg; DW) and cyclophosphamide (50 mg/kg) as negative (NC) and positive (PC) controls, respectively. Results: The results suggest that nCNSL at 34.7 and 69.5 mg/kg and Cardanol at all tested doses induced significant genotoxic effects to the female mouse bone marrow cells, while iCNSL did not. Both nCNSL and iCNSL as well as Cardanol did not show mutagenic and cytotoxic effects. All the test samples also showed DNA repair capacity at low dose. Conclusion: Cashew nut shell liquids and Cardanol showed genotoxic effects at high dose, but DNA repair, nonmutagenic and non-cytotoxic effects at low dose.

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“…The stem bark, fruits, and leaf extract, have pharmaceutical properties and extensively used as antiin ammatory, antioxidant, antibacterial, and antidiarrheal [13][14][15][16]. The anti-diabetic and anti-in ammatory properties have also been reported [17].…”

Section: Introductionmentioning

confidence: 99%

The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium Occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Male Wistar Rats

Ajao

Olamoyegun

Iyedupe

2021

Preprint

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Background: This research work investigated the antidiabetic, anti-hyperlipidemic, and antioxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin (STZ)-induced diabetic Wistar rats. Methods: Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8 rats each. Group 1 served as the control; Group 2-5 were induced with diabetes with a single dose of 50mg/kg bw of streptozotocin intraperitoneally. After diabetes induction, Group 2 served as the STZ-only group, Groups 3 and 4 were administered 100mg/kg bw and 200mg/kg bw p.o Anacardium occidentale nut extract, respectively, while Group 5 was administered 2mg/kg bw of glimepiride as a reference drug for a period of 4 weeks. Food and water intake were monitored daily, body weight, and blood glucose levels weekly throughout the experiment. On day 29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Results: Administration of the nut extract significantly (p<0.05) increased the food intake and body weight of diabetic treated rats, fasting blood glucose level and oral glucose tolerance test (OGTT) decreased significantly (p<0.05) in treated rats. On lipid profile, administration of nut extract significantly decreased (p<0.05) triglyceride, low-density lipoprotein, total cholesterol, and very-low-density lipoprotein concentrations while it significantly increases (p<0.05) the high-density lipoprotein. Anacardium occidentale nut extract caused significantly (p<0.05) increases in SOD, GPx, GSH, and CAT levels with a decrease MDA level in diabetic treated rats. Markers of liver and kidney functions were also improved in diabetic treated rats.Conclusion: Treatment with Anacardium occidentale methanolic nut extract has hypoglycemic, hypolipidemic, and hepato-protective effects in diabetic rats. It also alleviates oxidative stress activity and restoration of markers of kidney function, and may be useful as alternative therapy in the management of diabetes and its related complications.

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Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL)

Cited by 26 publications

References 36 publications

Phenolic compounds in agri-food by-products, their bioavailability and health effects

Phenolic compounds in agri-food by-products, their bioavailability and health effects

Cytogenotoxic and mutagenic profiling of cashew nut shell liquids and cardanol

The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium Occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Male Wistar Rats

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