Molecular Evidence: EA May Inhibit the Muscle Atrophy

Takaoka, Yutaka; Ohta, Mika; Sugano, Aki

doi:10.5772/23450

Cited by 1 publication

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study indicated that EA treatment suppressed Mstn expression, which led to a satellite cell-related proliferative reaction and repair in skeletal muscle [ 5 ]. Other results showed that EA-induced Mstn gene suppression may help prevent muscle atrophy in mice [ 10 ]. We subsequently found suppression of expression of the Mstn gene in mouse skeletal muscle after FL irradiation, just as with EA [ 4 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of femtosecond lasers for application of acupuncture therapy

et al. 2016

Self Cite

View full text Add to dashboard Cite

Acupuncture treatment utilizes the stimulation of metal acupuncture needles that are manually inserted into a living body. In the last decades, laser light has been used as an alternative to needles to stimulate acupuncture points. We previously reported suppression of myostatin (Mstn) gene expression in skeletal muscle by means of femtosecond laser (FL) irradiation, after electroacupuncture, in which acupuncture needles are stimulated with a low-frequency microcurrent. The purpose of the study here was to investigate the efficacy of FL irradiation in mouse skeletal muscle with regard to protein synthesis. After irradiation of the hindlimbs, we first analyzed Mstn gene expression and Mstn protein level in the skeletal muscle. We then evaluated phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream target 70-kDa ribosomal protein S6 kinase (p70S6K). The results showed that FL irradiation significantly reduced the amount of Mstn protein and enhanced the phosphorylation of p70S6K in of the mTOR/S6K signaling pathway. We suggest that FL irradiation activated the protein synthetic pathway in the skeletal muscle. In conclusion, we determined that FL irradiation can serve as an alternative for acupuncture needles and has the potential of being a new non-invasive acupuncture treatment of skeletal muscle.

show abstract