Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts

Degrelle, Séverine A.; Campion, Evelyne; Cabau, Cédric; Piumi, François; Reinaud, Pierrette; Richard, Christophe; Renard, Jean‐Paul; Hue, Isabelle

doi:10.1016/j.ydbio.2005.09.043

Cited by 188 publications

(199 citation statements)

References 69 publications

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“…A total of 452 genes were significantly up-regulated from Day 14 through Day 21 with only two being down-regulated. Degrelle et al (2005) compared gene expression in ovoid, tubular and filamentous conceptuses and presented data supporting an important role of the ovoid stage during blastocyst growth and differentiation. The persistent expression of epiblast (Oct-4.…”

Section: Gene Expression In the Conceptusmentioning

confidence: 99%

Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle

Lonergan¹,

Forde²

2014

Animal

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Early embryo development following fertilization occurs in the oviduct. However, despite being the site of fertilization in cattle, it is possible to by-pass the oviduct by producing embryos in vitro and/or by transferring blastocysts recovered from one female into the uterus of another. While there is substantial evidence for the oviduct having an influence on the quality of the developing embryo, manifested in altered morphology, gene expression and cryotolerance, evidence for a two-way dialogue is weak. In contrast, successful growth and development of the post-hatching blastocyst and pregnancy establishment are a result of the two-way interaction between a competent embryo and a receptive uterine environment. Progesterone (P4) plays a key role in reproductive events associated with establishment and maintenance of pregnancy through its action on the uterine endometrium. Elevated concentrations of circulating P4 in the immediate post-conception period have been associated with an advancement of conceptus elongation, an increase in interferon-tau production and, in some studies, higher pregnancy rates in cattle. This review summarizes current knowledge on the communication between the developing embryo and the maternal reproductive tract.

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Section: Gene Expression In the Conceptusmentioning

confidence: 99%

Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle

Lonergan¹,

Forde²

2014

Animal

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“…Chen et al (2000) identified that the extraembryonic mesoderm is the primary site of FGF10 expression in ovine conceptuses. The extraembryonic mesoderm emerges from the epiblast (i.e., the gastrulating inner cell mass) around days 14-16 of pregnancy in cattle and soon thereafter extends between the trophectoderm and endoderm to establish the inner chorionic layer and the outer yolk sac layer (Betteridge & Flechon 1988, Hue et al 2001, Maddox-Hyttel et al 2003, Degrelle et al 2005, Robinson et al 2006. Although, localization studies were not completed herein to verify the sources of FGF10 expression during conceptus elongation, our assessment of FGF10 mRNA abundance is supportive of the concept that the profound rise in FGF10 expression in day 14 and 17 conceptuses stems from the formation and expansion of extraembryonic mesoderm.…”

Section: Fgfs In Bovine Conceptusesmentioning

confidence: 99%

Several fibroblast growth factors are expressed during pre-attachment bovine conceptus development and regulate interferon-tau expression from trophectoderm

Cooke¹,

Pennington²,

Yang³

et al. 2009

Reproduction

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The trophectoderm-derived factor interferon tau (IFNT) maintains the uterus in a pregnancy-receptive state in cattle and sheep. Fibroblast growth factors (FGFs) are implicated in regulating IFNT expression and potentially other critical events associated with early conceptus development in cattle. The overall objectives of this work were to identify the various FGFs and FGF receptors (FGFRs) expressed in elongating pre-attachment bovine conceptuses and determine if these FGFs regulate conceptus development and/or mediate IFNT production. In vitro-derived bovine blastocysts and in vivo-derived elongated conceptuses collected at day 17 of pregnancy express at least four FGFR subtypes (R1c, R2b, R3c, R4). In addition, transcripts for FGF1, 2, and 10 but not FGF7 are present in elongated bovine conceptuses. The expression pattern of FGF10 most closely resembled that of IFNT, with both transcripts remaining low in day 8 and day 11 conceptuses and increasing substantially in day 14 and day 17 conceptuses. Supplementation with recombinant FGF1, 2 or 10 increased IFNT mRNA levels in bovine trophectoderm cells and bovine blastocysts and increased IFNT protein concentrations in trophectoderm-conditioned medium. Blastocyst development was not affected by any of the FGFs. In summary, at least four FGFRs reside in pre-and peri-attachment bovine conceptuses. Moreover, conceptuses express at least three candidate FGFs during elongation, the time of peak IFNT expression. These findings provide new insight for how conceptus-derived factors such as FGF1, 2, and 10 may control IFNT expression during early pregnancy in cattle.

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“…Oct4 likely functions primarily as the first determinant of ICM cell lineage by preventing their differentiation into TE cells, while Nanog is thought to act as a crucial keeper of pluripotency of some ICM cells (epiblast) by preventing their differentiation into primitive endoderm cells [29,30]. Although the localization of OCT4 and CDX2 in the ICM and TE and/or their contributions to ICM/TE lineage segregation are different between mouse and bovine blastocysts [21,28,31,32], NANOG expression has been shown to be confined to the ICM also in bovine blastocysts at least in the spherical stage [21,28,31], and its expression is likely to be implicated in ICM lineage determination also in the bovine [28]. Forced overexpression of Nanog in mouse ES cells led to autonomous self-renewal of the cells with retention of the undifferentiated state [29].…”

mentioning

confidence: 99%

Importance of Methionine Metabolism in Morula-to-blastocyst Transition in Bovine Preimplantation Embryos

Ikeda

Sugimoto

Kume

2012

Journal of Reproduction and Development

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Abstract. The roles of methionine metabolism in bovine preimplantation embryo development were investigated by using ethionine, an antimetabolite of methionine. In vitro produced bovine embryos that had developed to the 5-cell stage or more at 72 h after the commencement of in vitro fertilization (IVF) were then cultured until day 8 (IVF = day 0) in medium supplemented with 0 (control), 1, 5 and 10 mM ethionine. Compared with the blastocyst development in the control (40.0%), ethionine at 10 mM almost completely blocked blastocyst development (1.1%, P<0.001), and this concentration was used in the following experiments. Methionine added at the same concentration (10 mM, a concentration control of ethionine) did not cause such an intense developmental inhibition. Development to the compacted morula stage on day 6 was not affected by 10 mM ethionine treatment. S-adenosylmethionine (SAM) added to the ethionine treatment partly restored the blastocyst development. Semiquantitative reverse transcription-polymerase chain reaction analysis of cell lineage-related transcription factors in day 6 compacted morulae showed that the expressions of NANOG and TEAD4 were increased by ethionine treatment relative to the control (P<0.01). Furthermore, immunofluorescence analysis of 5-methylcytosine revealed that DNA was hypomethylated in the ethionine-treated day 6 morulae compared with the control (P<0.001). These results demonstrate that the disruption of methionine metabolism causes impairment of the morula-toblastocyst transition during bovine preimplantation development in part via SAM deficiency, indicating the indispensable roles of methionine during this period. The disruption of methionine metabolism may cause hypomethylation of DNA and consequently lead to the altered expression of developmentally important genes, which then results in the impairment of blastocyst development. Key words: Bovine, Methionine, One-carbon metabolism, Preimplantation embryo, S-adenosylmethionine (J. Reprod. Dev. 58: [91][92][93][94][95][96][97] 2012) M ethionine is a dietary essential amino acid that plays multiple biological roles, including those as the initiating amino acid in eukaryotic protein synthesis, a precursor of the essential methyl donor for methylation reactions (S-adenosylmethionine, SAM) and a source of redox regulators (cysteine and glutathione) [1,2]. Methionine metabolism can be seen as the trans-and remethylation cycle of methionine (methionine cycle) that intertwines with the cycle of folate metabolism (folate cycle) and the transsulfuration pathway from homocysteine, an intermediate in the methionine cycle [3], and these combined metabolic networks are called one-carbon metabolism [4,5]. Recently, mammalian oocytes and preimplantation embryos have been reported to express the key regulatory enzymes in one-carbon metabolism [6][7][8], suggesting that mammalian oocytes and preimplantation embryos can independently utilize and metabolize nutrients in one-carbon metabolism, such as methionine, choline, betaine, folates a...

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Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts

Cited by 188 publications

References 69 publications

Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle

Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle

Several fibroblast growth factors are expressed during pre-attachment bovine conceptus development and regulate interferon-tau expression from trophectoderm

Importance of Methionine Metabolism in Morula-to-blastocyst Transition in Bovine Preimplantation Embryos

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