Drug Resistance in Leishmania Parasites 2012
DOI: 10.1007/978-3-7091-1125-3_2
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Molecular Evolution and Phylogeny of Leishmania

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Cited by 13 publications
(17 citation statements)
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“…However, because of its lower intra-species discriminatory power and the need for parasite mass cultivation, it has been superseded by other techniques as multilocus sequence typing (MLST), multilocus microsatellite typing (MLMT), polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and sequencing of specific genetic markers such as hsp70, ribosomal DNA (rDNA) and the kinetoplastid DNA (kDNA) (Schönian et al 2008Yuan et al 2017;Ghatee et al 2018b). Of these, MLMT and kDNA-RFLP are the most powerful techniques for studying Leishmania populations in intraspecies level , Schönian et al 2013). However, challenges remain.…”
Section: Introductionmentioning
confidence: 99%
“…However, because of its lower intra-species discriminatory power and the need for parasite mass cultivation, it has been superseded by other techniques as multilocus sequence typing (MLST), multilocus microsatellite typing (MLMT), polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and sequencing of specific genetic markers such as hsp70, ribosomal DNA (rDNA) and the kinetoplastid DNA (kDNA) (Schönian et al 2008Yuan et al 2017;Ghatee et al 2018b). Of these, MLMT and kDNA-RFLP are the most powerful techniques for studying Leishmania populations in intraspecies level , Schönian et al 2013). However, challenges remain.…”
Section: Introductionmentioning
confidence: 99%
“…The majority of molecular phylogenetic studies of Leishmania have relied on a few genetic loci to infer evolutionary relationships (Schönian et al, 2013). These data may not accurately reflect the true history of the genus and also provide limited information with which to estimate the age of splits between clades (Castresana, 2007;Momen and Cupolillo, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…These tools except from their enhanced sensitivity they are also able to distinguish Leishmania parasites at species and intraspecies level. As for phylogenetic studies, the sequence analysis of single-copy gene targets is preferred while also the recombination and the different mutation rates between lineages make the use of one gene less suitable for the phylogenic analysis of the Trypanosomatidae or its subgroups [163].…”
Section: Leishmaniasis -Trends In Epidemiology Diagnosis and Treatmementioning
confidence: 99%