Molecular Evolution of Human Immunodeficiency Virus
            <i>env</i>
            in Humans and Monkeys: Similar Patterns Occur during Natural Disease Progression or Rapid Virus Passage

Hofmann‐Lehmann, Regina; Vlasak, Josef; Chenine, Agnès‐Laurence; Li, Peilin; Baba, Timothy W.; Montefiori, David C.; McClure, Harold M.; Anderson, Daniel C.; Ruprecht, Ruth M.

doi:10.1128/jvi.76.10.5278-5284.2002

Cited by 20 publications

(19 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…periods that in individual hosts ranged from 4 to 20 months, the same viral populations invariably became resistant to all or most immune sera; i.e., they reverted to the BNR phenotype typical of primary isolates. Similar observations have been made for TCA strains of HIV-1 and chimeric simian immunodeficiency virus-HIV (2,7,12). Interestingly, reversion to the BNR phenotype of TCA FIV generally occurred when Env mutation rates had already declined relative to early times p.i.…”

supporting

confidence: 61%

“…At this time, it is not known how the present findings may be representative of the situation in other lentiviruses. However, a strain of simian immunodeficiency virus-HIV encoding the Env of a TCA HIV-1 strain was reinjected in vivo and was recently seen to become neutralization resistant and increasingly virulent by changing its Env at the same amino acid positions in individual hosts of different primate species (12), thus suggesting that the amino acid positions of Env that played a key role in permitting in vivo per- Aliquots of serum obtained from cat 275 at 55 months p.i. were repeatedly adsorbed with virions of the indicated clones until the reactivity for the adsorbing clone was exhausted and were then tested for residual binding activity against clones Asn-Asn (A) and Lys-Ser (B).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of Two Amino Acid Positions Governing Broad Neutralization Resistance in a Strain of Feline Immunodeficiency Virus over 7 Years of Persistence in Cats

Pistello

Matteucci

Giannecchini

et al. 2003

Clin Vaccine Immunol

View full text Add to dashboard Cite

Fresh isolates of lentiviruses are characterized by an outstanding resistance to antibody-mediated neutralization. By investigating the changes that occurred in a neutralization-sensitive tissue culture-adapted strain of feline immunodeficiency virus after it was reinoculated into cats, a previous study had identified two amino acid positions of the surface glycoprotein (residues 481 and 557) which govern broad neutralization resistance (BNR) in this virus. By extending the follow-up of six independently evolving in vivo variants of such virus for up to 92 months, we now show that the changes at the two BNR-governing positions not only were remarkably stereotyped but also became fixed in an ordered sequential fashion with the duration of in vivo infection. In one variant, the two positions were also seen to slowly alternate at determining BNR. Evidence that evolution at the BNR-governing positions was accompanied, and possibly driven, by changes in the antigenic makeup of the viral surface brought about by the mutations at such positions is also presented.

show abstract

supporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Evolution of Two Amino Acid Positions Governing Broad Neutralization Resistance in a Strain of Feline Immunodeficiency Virus over 7 Years of Persistence in Cats

Pistello

Matteucci

Giannecchini

et al. 2003

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…In our primate studies (4,5,21; unpublished data), depletion of CD4 ϩ CD29 ϩ memory T cells preceded the loss of absolute numbers of CD4 ϩ T cells by several months to years. Within the time of follow-up of the current two groups of monkeys, we did not observe significant changes in either absolute CD4 ϩ T-cell counts or CD4 ϩ /CD8 ϩ ratios.…”

Section: Discussionmentioning

confidence: 99%

Coinfection with Schistosoma mansoni Reactivates Viremia in Rhesus Macaques with Chronic Simian-Human Immunodeficiency Virus Clade C Infection

et al. 2007

Self Cite

View full text Add to dashboard Cite

We tested the hypothesis that helminth parasite coinfection would intensify viremia and accelerate disease progression in monkeys chronically infected with an R5 simian-human immunodeficiency virus (SHIV) encoding a human immunodeficiency virus type 1 (HIV-1) clade C envelope. Fifteen rhesus monkeys with stable SHIV-1157ip infection were enrolled into a prospective, randomized trial. These seropositive animals had undetectable viral RNA and no signs of immunodeficiency. Seven animals served as virus-only controls; eight animals were exposed to Schistosoma mansoni cercariae. From week 5 after parasite exposure onward, coinfected animals shed eggs in their feces, developed eosinophilia, and had significantly higher mRNA expression of the T-helper type 2 cytokine interleukin-4 (P ‫؍‬ 0.001) than animals without schistosomiasis. Compared to virus-only controls, viral replication was significantly increased in coinfected monkeys (P ‫؍‬ 0.012), and the percentage of their CD4 ؉ CD29 ؉ memory cells decreased over time (P ‫؍‬ 0.05). Thus, S. mansoni coinfection significantly increased viral replication and induced T-cell subset alterations in monkeys with chronic SHIV clade C infection.

show abstract

“…The role of env sequences in lentivirus virulence has been clearly demonstrated in simian-human immunodeficiency virus (SHIV)-infected rhesus macaques (7,8,11,12,16,20,22,27,43). As few as 12 amino acid differences in the env sequence are sufficient to change pathogenic potential of SHIV clones (43).…”

Section: Discussionmentioning

confidence: 99%

“…As few as 12 amino acid differences in the env sequence are sufficient to change pathogenic potential of SHIV clones (43). Most of the env changes that arise with increased virulence are localized to gp120 variable regions; changes in the number and position of N-linked glycosylation sites are common (7,8,16,27,43). Some measurable differences in virulent SHIVs that have been attributed to env sequence changes include fusogenicity, resistance to neutralization, and increased replicative potential (7,8,43).…”

Section: Discussionmentioning

confidence: 99%

Influence of Long Terminal Repeat and Env on the Virulence Phenotype of Equine Infectious Anemia Virus

Payne

Pei

Jia

et al. 2004

J Virol

View full text Add to dashboard Cite

The molecular clones pSPeiav19 and p19/wenv17 of equine infectious anemia virus (EIAV) differ in env and long terminal repeats (LTRs) and produce viruses (EIAV 19 and EIAV 17 , respectively) of dramatically different virulence phenotypes. These constructs were used to generate a series of chimeric clones to test the individual contributions of LTR, surface (SU), and transmembrane (TM)/Rev regions to the disease potential of the highly virulent EIAV 17 . The LTRs of EIAV 19 and EIAV 17 differ by 16 nucleotides in the transcriptional enhancer region. The two viruses differ by 30 amino acids in SU, by 17 amino acids in TM, and by 8 amino acids in Rev. Results from in vivo infections with chimeric clones indicate that both LTR and env of EIAV 17 are required for the development of severe acute disease. In the context of the EIAV 17 LTR, SU appears to have a greater impact on virulence than does TM. EIAV 17SU , containing only the TM/Rev region from the avirulent parent, induced acute disease in two animals, while a similar infectious dose of EIAV 17TM (which derives SU from the avirulent parent) did not. Neither EIAV 17SU nor EIAV 17TM produced lethal disease when administered at infectious doses that were 6-to 30-fold higher than a lethal dose of the parental EIAV 17 . All chimeric clones replicated in primary equine monocyte-derived macrophages, and there was no apparent correlation between macrophage tropism and virulence phenotype.

show abstract

Molecular Evolution of Human Immunodeficiency Virus env in Humans and Monkeys: Similar Patterns Occur during Natural Disease Progression or Rapid Virus Passage

Cited by 20 publications

References 48 publications

Evolution of Two Amino Acid Positions Governing Broad Neutralization Resistance in a Strain of Feline Immunodeficiency Virus over 7 Years of Persistence in Cats

Evolution of Two Amino Acid Positions Governing Broad Neutralization Resistance in a Strain of Feline Immunodeficiency Virus over 7 Years of Persistence in Cats

Coinfection with Schistosoma mansoni Reactivates Viremia in Rhesus Macaques with Chronic Simian-Human Immunodeficiency Virus Clade C Infection

Influence of Long Terminal Repeat and Env on the Virulence Phenotype of Equine Infectious Anemia Virus

Contact Info

Product

Resources

About