Molecular Examination of Trichomonas vaginalis Infection and Risk of Prostate Cancer in the Biopsy of Patients with Different Prostate Lesions

Kamarkhani, Zeinab; Rafiei-Sefiddashti, Raheleh; Haghighi, Ladan; Badirzadeh, Alireza; Hadighi, Ramtin

doi:10.4314/ejhs.v31i2.5

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…T. vaginalis infection in the urogenital tract could display distinct phenotypes. [ 18 ] However, the current adult patient was an extremely rare case. On the one hand, previous reports showed that pulmonary T. vaginalis infection mainly occurred in neonates due to maternal infection.…”

Section: Discussionmentioning

confidence: 99%

Trichomonas vaginalis in bronchoalveolar lavage fluid of a patient with severe pneumonia detected by metagenomic next-generation sequencing: A case report

Li,

Wang,

Gou

et al. 2023

Medicine

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Rationale: Trichomonas vaginalis (T. vaginalis) is a common anaerobic parasitic protozoan. However, to the best of our knowledge, there are few reports documenting T. vaginalis infection outside the genitourinary tract. Severe pneumonia caused by T. vaginalis infection has been rarely reported. Patient concerns: The 80-year-old female patient had a 20-year history of type II diabetes; however, she was not on regular medication. She was hospitalized due to a coma which continued 2 hours caused by trauma after a car accident. After her admission, she was provided with continuous mechanical ventilation; during the ventilation, she was still in a coma, accompanied by repeated fever and presence of much yellow sticky phlegm. The head CT scan indicated temporal lobe hematoma and subarachnoid hemorrhage. The lung CT scan showed bilateral pulmonary inflammatory consolidation and mass lesions. Diagnoses: She was initially diagnosed with severe pneumonia and acute respiratory distress syndrome. Subsequently, fiberoptic bronchoscopy was conducted, and bronchoalveolar lavage fluid (BALF) was collected and sent for metagenomic next-generation sequencing (mNGS). The result indicated the presence of abundant sequences from the T. vaginalis genome. Thus, she was diagnosed with pulmonary T. vaginalis infection. Intervention: Anti-infective ornidazole treatment has significantly improved her symptoms. Outcomes: After treatment, the patient regained consciousness and was able to communicate, and there was no obvious expectoration, fever, or positive bronchus sign in the lungs. Thereby, she was discharged from the hospital. Lessons: Special attention should be paid to infections other than common bacterial infections, such as T. vaginalis. Moreover, infection of rare pathogenic microorganisms might show symptoms similar to common bacterial infection, leading to misdiagnosis, further highlighting the usefulness of mNGS in detecting pathogens in a timely, sensitive, and accurate manner.

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Section: Discussionmentioning

confidence: 99%

Trichomonas vaginalis in bronchoalveolar lavage fluid of a patient with severe pneumonia detected by metagenomic next-generation sequencing: A case report

Li,

Wang,

Gou

et al. 2023

Medicine

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“…It is worthy of note to mention the established relationship between a complication (urinary tract infections) stemming from the incidence of BPH and sexually transmitted diseases (STDs) (Kamarkhani et al, 2021), because more often than not, medicinal plants used in the treatment of Sexually Transmitted Infections (STIs) have been utilized in the management of BPH. These medicinal plants have been reported to contain phytohormones and other pharmacologically active constituents that have ameliorated the incidence of BPH (Chen et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Gegele,

Ajayi,

Attah

et al. 2023

njpr

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Background: Benign Prostate Hyperplasia (BPH) is a prevalent illness in older men. It is a condition where the prostate becomes enlarged and blocks the ease of urine passage out of the bladder. Around 50% of the male population develops symptoms of BPH around 51- 60 years of age. Current therapeutic management options come with undesirable side effects like weight gain, dizziness, and impotence, hence, the need to source for safer alternatives initiated by the acquisition, recording, and preservation of traditional knowledge of medicinal plants. Objective: This study aims to preserve indigenous knowledge by documenting medicinal herbs in use as therapy for BPH. Materials & method: Ethnobotanical survey was carried out in the study areas through interviews using a semistructured questionnaire. Respondents included elderly members of the communities, herbalists, and practitioners of traditional medicine. Quantitative ethnobotany index (Use value index) and descriptive statistics were used to analyse data. Results: 50 respondents were interviewed, 64% were Herb sellers, 22% TMPs, Others 14%. 37 plants belonging to 24 plant families were mentioned in the survey. Methods of preparation of recipes mentioned includes: maceration (37%), decoctions (52%), juice (7%), infusions and paste/powder (4%). Method of administration were majorly oral route. The plant family Fabaceae (19%) had the highest representation. This was followed by the families Annonaceae (8%), Euphorbiaceae (6%), Curcubitaceae, Menispermaceae, Combretaceae, Apocynaceae and Rutaceae with 5% each. Other plant families represented 42% of the total number of plants mentioned. Conclusion: The study areas are endowed with abundant flora which serves as a repository for researchers in the quest to develop less toxic drugs with little or no side-effect for the management of BPH

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“…An Egyptian study, involving 445 men, identified that while only 8.3% of controls were seropositive for trichomoniasis, this proportion rose to 19% in PC patients, and was associated with PSA levels and tumor stage; however, no impact on prognosis or mortality was observed (p<0.001 and p<0.05) (Saleh et al, 2020). In Iran, 250 samples of prostate lesions were analyzed using PCR, all were negative; however, studies that reported associations between these two factors used serology for T. vaginalis, thus PCR may not be the most appropriate technique to determine an association (Kamarkhani et al, 2021).…”

Section: Case-control Studiesmentioning

confidence: 99%

Trichomonas vaginalis and prostate cancer: A systematic review

Lopes,

Oliveira,

Fonseca

et al. 2024

RSD

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Introduction: Prostate cancer (PC) is the second most frequent neoplasm in men accounting for 29% of tumor cases, at a rate of 1.4 million new cases and 375,000 deaths globally each year. Although its high prevalence, little is known about its etiology. Sexually transmitted infections (STIs) are one of the factors under discussion for a possible risk factor. Trichomoniasis is a prevalent STI caused by the pathogenic protozoan Trichomonas vaginalis that has been associated with the incidence of PC. Objectives: This review aims to determine whether the T. vaginalis is a risk factor for the development and/or progression of the disease. Methodology: A systematic review was conducted using the PubMed and Scielo databases. The following descriptors were used: “Prostate Cancer”; “Trichomonas vaginalis”; “Trichomonosis”; “Prostate”, all indexed in DeCS/MeSH. Results and Discussion: In total, 24 articles were included (8 in vitro studies; 1 in vivo study; 3 prospective studies; 9 case-control studies; 2 randomized clinical trials; and 1 systematic review and meta-analysis). Conclusion: Even though in vitro and in vivo studies analyzed credibly indicate the existence of this pathophysiology, these findings have not been reproduced in most populations studies conducted, throughout the years. More recent studies involving a bigger database indicates an association. This leads us to believe that new population studies should be conducted to obtain a consensus so that educational and preventive measures can be implemented.

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Molecular Examination of Trichomonas vaginalis Infection and Risk of Prostate Cancer in the Biopsy of Patients with Different Prostate Lesions

Cited by 5 publications

References 14 publications

Trichomonas vaginalis in bronchoalveolar lavage fluid of a patient with severe pneumonia detected by metagenomic next-generation sequencing: A case report

Trichomonas vaginalis in bronchoalveolar lavage fluid of a patient with severe pneumonia detected by metagenomic next-generation sequencing: A case report

Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Trichomonas vaginalis and prostate cancer: A systematic review

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