Molecular features of giant-cell carcinoma of the lung: a case report and literature review

Li, Xin; Zhang, Zihe; Liu, Jinghao; Wang, Dan; Wei, Sen; Chen, Jun

doi:10.2147/ott.s150124

Cited by 9 publications

(14 citation statements)

References 29 publications

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“…GCCL is associated with smoking, and it is more commonly seen in males [ 5 ]. GCCL can occur in any lung lobe, but it is more commonly found in the upper lobes [ 7 ]. GCCL may be asymptomatic like other NSCLCs, or patients may complain of non-specific signs and symptoms like cough or hemoptysis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…GCCL can occur in any lung lobe, but it is more commonly found in the upper lobes [ 7 ]. GCCL may be asymptomatic like other NSCLCs, or patients may complain of non-specific signs and symptoms like cough or hemoptysis [ 7 ]. GCCL is a poorly differentiated tumor with early metastasis to the brain, bone, adrenal gland, and liver, through lymph and blood circulation.…”

Section: Discussionmentioning

confidence: 99%

“…GCCL is a poorly differentiated tumor with early metastasis to the brain, bone, adrenal gland, and liver, through lymph and blood circulation. Uncommon metastasis to the gastrointestinal tract, kidney, and heart has also been reported [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…GCCL is easily distinguished from other forms of lung cancers by histopathology [ 3 ]. Under the microscope, GCCL tumor cells are big, multi-core, bizarre with plenty of neutrophils and lymphocytes in the background [ 7 ]. A characteristic feature of GCCL is emperipolesis, which is the presence of collections of polymorphonuclear leukocytes within the giant cells, apparently phagocytosing cytoplasmic contents [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection is an effective treatment and provides adequate control for limited-stage GCCL [ 7 ]. Patients with NSCLC are at substantial risk for recurrence and death even after complete surgical resection [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin

Habib

Leifer

Azam

et al. 2018

Respiratory Medicine Case Reports

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Giant Cell Carcinoma of the lung, a subtype of Sarcomatoid lung cancer is a poorly differentiated Non-Small-Cell Lung Cancer. GCCL has exceptionally aggressive characteristics, and its prognosis is much poorer than any other NSCLCs. Herein, we present a rare case of Giant Cell Carcinoma of lung treated successfully with surgical resection and adjuvant vinorelbine and cisplatin.A 48-year-old African American man with a history of smoking and chronic obstructive pulmonary disease was admitted to the hospital for chief complaints of shortness of breath. He was found to have a 3.5 cm × 3.3 cm x 2.8 cm cavitary right upper lobe mass which turned out to be poorly differentiated Giant Cell Carcinoma with extensive necrosis and deemed similar to stage 1b non-small cell lung cancer. He was successfully treated with right upper lobectomy and adjuvant chemotherapy with vinorelbine and cisplatin. He was followed for seven years with no evidence of recurrent disease.Giant Cell Carcinoma's existing literature is limited, and hence our case is reportable. Our case is unique because of the better outcome which we believe might be the result of early detection and treatment with surgical resection along with adjuvant chemotherapy. More studies are needed to deeply understand the need for adjuvant chemotherapy in stage 1 b GCCL, and proper guidelines are required for the indications of adjuvant chemotherapy in Stage 1b GCCL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin

Habib

Leifer

Azam

et al. 2018

Respiratory Medicine Case Reports

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Giant cell carcinoma of the urinary bladder

Portugal-Gaspar,

Lopez-Beltran,

Paner

et al. 2024

Virchows Arch

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We present the clinicopathological features of 23 cases of the giant cell subtype of urothelial carcinoma, a rare subtype of bladder cancer recognized in the current World Health Organization classification of urological tumors. Histologically, the architectural pattern of the tumor varied from infiltrating to the solid expansile pleomorphic tumor with giant, bizarre, anaplastic cells. Typical or atypical mitotic figures were frequently present in all cases. Between 10 and 30% of the tumor had a giant cell component. All cases were associated with conventional high-grade urothelial carcinoma, with areas of squamous cell divergent differentiation and micropapillary carcinoma present in six and two cases, respectively. In one case each had sarcomatoid, nested, small cell, or glandular divergent differentiation. At diagnosis, 35% of patients had advanced disease and 12% had distant metastases. When comparing giant cell urothelial carcinoma with conventional urothelial carcinoma in a matched analysis, differences in overall and cancer-specific survival were observed, particularly in the T1 stage category. Immunohistochemical staining showed a similar profile of urothelial lineage with frequent positive expression of uroplakin II, GATA3, CK20, CK7, and S100P in both giant cell and conventional urothelial carcinomas. High Ki67 proliferation (range, 60–90%; mean, 71%) and nuclear p53 accumulation (mutant profile; range, 50–90%; mean, 64%) were observed. Using the 22C3 assay, the expression of PD-L1 was found to be variable in two cases, and beta-HCG was negative. In conclusion, giant cell carcinoma is a subtype of urothelial carcinoma associated with advanced clinical stage and a trend to lower survival rates.

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Giant cell carcinoma of the lung presenting as an isolated cyst containing air

Wang¹,

Liu²,

Qian³

et al. 2019

Medicine

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Introduction: Pulmonary sarcomatoid carcinomas (PSCs) are rare tumors within the sarcomatoid carcinoma group. Giant cell carcinoma of the lung (GCCL) is a rare type of PSCs that consists entirely of highly pleomorphic tumor giant cells; the prognosis is poor. Patient concerns: A patient presented with a single cyst and was diagnosed with GCCL. The patient was a 59-year-old male who was admitted to the hospital with a cough. A chest computerized tomography (CT) scan showed a single, thin-walled cyst containing air in the left upper lobe of the lung. Bronchoscopy revealed chronic bronchitis. The initial diagnosis was pulmonary infection and the patient was treated with antibiotics. The cyst wall increased in thickness, and the cyst eventually formed a cavity. Diagnosis: Surgery was performed, and a diagnosis of GCCL was established. The stage was pT 1b N 1 M 0 (equal to stage IIB). Interventions: The patient underwent video-assisted thoracoscopic surgery and 4 cycles of adjuvant chemotherapy consisting of cisplatin and docetaxel. After 9 months, the patient occurred mediastinal lymph node metastasis, and received radiotherapy (60Gy/30F). Outcomes: His prognosis was good without progression (complete response) based on serial CT scans over 9 months of follow-up evaluations, then the patient occurred mediastinal lymph node metastasis. The patient lived during 30 months of follow-up, after which he was lost to follow-up. Conclusion: A solitary pulmonary parenchymal cystic lesion usually suggests an infectious disease or congenital abnormality; however, a cystic lesion is occasionally encountered in GCCL.

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Molecular features of giant-cell carcinoma of the lung: a case report and literature review

Cited by 9 publications

References 29 publications

Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin

Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin

Giant cell carcinoma of the urinary bladder

Giant cell carcinoma of the lung presenting as an isolated cyst containing air

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