Molecular Features, Prognostic Value, and Cancer Immune Interactions of Angiogenesis-Related Genes in Ovarian Cancer

Ji, Yurou; Ge, Qi; Zhang, Wenwen; Qu, Pengpeng

doi:10.1007/s43032-022-01123-6

Cited by 1 publication

(1 citation statement)

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“…Nevertheless, the potential effects of angiogenesis-related genes (ARGs) in ovarian cancer (OC) necessitate further investigation. Ji et al [ 111 ] revealed the substantial involvement of ARGs in the tumour–immune–stromal microenvironment, clinicopathological characteristics, and prognosis of OC patients.…”

Section: Interactions Between Csc and Non-tumour Cellsmentioning

confidence: 99%

The Role of Cancer Stem Cell Markers in Ovarian Cancer

Frąszczak,

Barczyński

2023

Cancers

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Ovarian cancer is the most lethal gynaecological cancer and the eighth most common female cancer. The early diagnosis of ovarian cancer remains a clinical problem despite the significant development of technology. Nearly 70% of patients with ovarian cancer are diagnosed with stages III–IV metastatic disease. Reliable diagnostic and prognostic biomarkers are currently lacking. Ovarian cancer recurrence and resistance to chemotherapy pose vital problems and translate into poor outcomes. Cancer stem cells appear to be responsible for tumour recurrence resulting from chemotherapeutic resistance. These cells are also crucial for tumour initiation due to the ability to self-renew, differentiate, avoid immune destruction, and promote inflammation and angiogenesis. Studies have confirmed an association between CSC occurrence and resistance to chemotherapy, subsequent metastases, and cancer relapses. Therefore, the elimination of CSCs appears important for overcoming drug resistance and improving prognoses. This review focuses on the expression of selected ovarian CSC markers, including CD133, CD44, CD24, CD117, and aldehyde dehydrogenase 1, which show potential prognostic significance. Some markers expressed on the surface of CSCs correlate with clinical features and can be used for the diagnosis and prognosis of ovarian cancer. However, due to the heterogeneity and plasticity of CSCs, the determination of specific CSC phenotypes is difficult.

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Section: Interactions Between Csc and Non-tumour Cellsmentioning

confidence: 99%