Molecular Genealogy of Some Nematode Taxa as Based on Cytochrome c and Globin Amino Acid Sequences

Vanfleteren, Jacques R.; Peer, Yves Van de; Blaxter, Mark; Tweedie, Susan; Trotman, C. N. A.; Lu, Limin; Hauwaert, M L Van; Moëns, Luc

doi:10.1006/mpev.1994.1012

Cited by 102 publications

(53 citation statements)

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“…Also, it is not uncommon that all other functionally unrelated bystander genes between PTPTRN and DNPEP, as in the case of C. elegans, are not clustered with PTPTRN or DNPEP and lost in other species after millions of years of evolutionary divergence and selection. 19,20) Considering that common ancestors of C. elegans and zebrafish in vertebrates diverged 450-500 million years, 9,21) we hypothesize that conserved genes within the same syntenic block keep similar tissue specific expression patterns in neuroendocrine tissues, including islets and neuronal tissues in the brain and the spinal cord, and hence are also be involved in similar biological functions. Using DAP-specific antibody in immunostaining and electron microscopy, we found that DAP was indeed expressed in the hormone secretory granules in islet cells, like its neighbors PTPRN and RESP18.…”

Section: Discussionmentioning

confidence: 99%

Aspartyl Aminopeptidase, Encoded by an Evolutionarily Conserved Syntenic Gene, Is Colocalized with Its Cluster in Secretory Granules of Pancreatic Islet Cells

Cai

Wang

Chen

2010

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Aspartyl Aminopeptidase, Encoded by an Evolutionarily Conserved Syntenic Gene, Is Colocalized with Its Cluster in Secretory Granules of Pancreatic Islet Cells

Cai

Wang

Chen

2010

Bioscience, Biotechnology, and Biochemistry

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“…Error in the estimated briggsae-elegans divergence date would make our rate estimate inaccurate, but it seems unlikely that we have overestimated the rate of rearrangement. For nematodes to have the same rearrangement rate as Drosophila, the briggsaeelegans divergence date would have to be 560-1020 Mya; however, the nematode order to which Caenorhabditis belongs arose only ∼400 Mya (Vanfleteren et al 1994). Caenorhabditis and Drosophila differ not only in the rate, but also in the type, of rearrangement seen.…”

Section: Discussionmentioning

confidence: 99%

Fourfold Faster Rate of Genome Rearrangement in Nematodes Than in Drosophila

Coghlan¹,

Wolfe²

2002

Genome Res.

188

170

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We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being ∼1:1:2. We estimate that the species diverged 50-120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4-1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C. elegans genome.[The following institution kindly provided reagents, samples or unpublished information as indicated in the paper:

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“…H. contortus diverged from Caenorhabditis approximately 400 million years ago, (94) which suggests that B. malayi is even more divergent. (78) While candidate homologs of most of the maternal and terminal differentiation genes seem to be present in H. contortus and B. malayi, many of the early zygotic regulators appear to be absent ( Table 1).…”

Section: Evolution Of the Endomesoderm Grn In Nematodesmentioning

confidence: 99%

Endomesoderm specification in Caenorhabditis elegans and other nematodes

Maduro

2006

BioEssays

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The endomesoderm gene regulatory network (GRN) of C. elegans is a rich resource for studying the properties of cell-fate-specification pathways. This GRN contains both cell-autonomous and cell non-autonomous mechanisms, includes network motifs found in other GRNs, and ties maternal factors to terminal differentiation genes through a regulatory cascade. In most cases, upstream regulators and their direct downstream targets are known. With the availability of resources to study close and distant relatives of C. elegans, the molecular evolution of this network can now be examined. Within Caenorhabditis, components of the endomesoderm GRN are well conserved. A cursory examination of the preliminary genome sequences of two parasitic nematodes, Haemonchus contortus and Brugia malayi, suggests that evolution in this GRN is occurring most rapidly for the zygotic genes that specify blastomere identity.

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Molecular Genealogy of Some Nematode Taxa as Based on Cytochrome c and Globin Amino Acid Sequences

Cited by 102 publications

References 0 publications

Aspartyl Aminopeptidase, Encoded by an Evolutionarily Conserved Syntenic Gene, Is Colocalized with Its Cluster in Secretory Granules of Pancreatic Islet Cells

Aspartyl Aminopeptidase, Encoded by an Evolutionarily Conserved Syntenic Gene, Is Colocalized with Its Cluster in Secretory Granules of Pancreatic Islet Cells

Fourfold Faster Rate of Genome Rearrangement in Nematodes Than in Drosophila

Endomesoderm specification in Caenorhabditis elegans and other nematodes

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