Molecular-Genetic Features of Tuberculosis in Mongolia and in Russian Bordering Regions

Бадлеева, М. В.; Жданова, С. Н.; Баасансурэн, Э. .; Огарков, О. Б.; Эрдэнэгэрэл, Н. .; Орлова, Е. А.; Оюунтуяа, Т. .; Савилов, Е. Д.; Буянхишиг, Б. .; Пунцаг, Б. .; Нямхуу, Д. .

doi:10.31631/2073-3046-2017-16-5-53-57

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…The TB incidence in these Russian regions, per 100,000, was 96.6 in Irkutsk, 66.1 in Buryatia and 59.3 in Zabaykalsky Krai (https://old.mednet.ru/ru/czentr-monitoringa-tuberkuleza.html). An increased rate of primary MDR‐TB from 9.5% in 2005 to 34.2% in 2019 highlights the active transmission of MDR strains in Russia (Badleyeva et al, 2017; Galkin et al., 2017; Testov et al., 2019). In contrast, in Mongolia, the TB incidence is higher (110 out of 100,000), but the primary MDR rate is much lower (4.3%).…”

Section: Discussionmentioning

confidence: 99%

Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia

Жданова

Mokrousov

Орлова

et al. 2022

Transbounding Emerging Dis

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Eastern Siberia (Russia) and Mongolia are borderline regions in Asia with a high incidence of tuberculosis (TB). In this study, we investigated the transborder transmission of Mycobacterium tuberculosis with a focus on endemic and epidemic clones and drug resistance. M. tuberculosis isolates (287 from Mongolia and 754 from Russia) were collected using cross‐sectional population‐based surveys between 2010 and 2016. The isolates were genotyped using 24 variable number of tandem repeat loci and by testing of the key markers to discriminate within the Beijing genotype. All isolates were divided into 427 mycobacterial interspersed repetitive units types that were assigned to Lineage 2 (Beijing) and Lineage 4 (Ural, Haarlem, Latin American‐Mediterranean [LAM], S, unclassified). The Beijing genotype was dominant in both countries (69% in Russia, 75% in Mongolia). However, the Beijing isolates differed significantly between the countries, in terms of the identified subtypes. LAM was the most common non‐Beijing genotype (11.1% in Mongolia and 14.9% in Russia) and LAM isolates mostly belonged to the LAM‐RUS branch in both countries. The multidrug‐resistance (MDR) rate was higher in Russia than in Mongolia among newly diagnosed patients: 29.4% versus 5.6% (p < .001). In Mongolia, the MDR rate was similar in Beijing (29.7%) and non‐Beijing (27.5%) genotypes. In Russia, a higher MDR rate was observed in (i) Beijing compared with non‐Beijing (48.7% versus 38.3%, p = .03) and (ii) Beijing B0/W148 compared with Beijing Central Asian/Russian (63.4% versus 37.3%, p < .001). In conclusion, the M. tuberculosis population structure in Mongolia was shaped by mainly historical interaction with China (dominance of the Beijing genotype) and Northern Eurasia (presence of the LAM‐RUS branch). In contrast, the transborder transmission of M. tuberculosis since the 1990s between Mongolia and its neighbours has been negligible, and the adverse trends of MDR‐TB in Russia did not impact the current situation in Mongolia.

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Section: Discussionmentioning

confidence: 99%

Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia

Жданова

Mokrousov

Орлова

et al. 2022

Transbounding Emerging Dis

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Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster

et al. 2023

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Background . The Mycobacterium tuberculosis Beijing genotype is globally spread lineage with important medical properties that however vary among its subtypes. M. tuberculosis Beijing 14717-15-cluster was recently discovered as both multidrug-resistant, hypervirulent, and highly-lethal strain circulating in the Far Eastern region of Russia. Here, we aimed to analyze its pathogenomic features and phylogeographic pattern. Results . The study collection included M. tuberculosis DNA collected between 1996 and 2020 in different world regions. The bacterial DNA was subjected to genotyping and whole genome sequencing followed by bioinformatics and phylogenetic analysis. The PCR-based assay to detect specific SNPs of the Beijing 14717-15-cluster was developed and used for its screening in the global collections. Phylogenomic and phylogeographic analysis confirmed endemic prevalence of the Beijing 14717-15-cluster in the Asian part of Russia, and distant common ancestor with isolates from Korea (> 115 SNPs). The Beijing 14717-15-cluster isolates had two common resistance mutations RpsL Lys88Arg and KatG Ser315Thr and belonged to spoligotype SIT269. The Russian isolates of this cluster were from the Asian Russia while 4 isolates were from the Netherlands and Spain. The cluster-specific SNPs that significantly affect the protein function were identified in silico in genes within different categories (lipid metabolism, regulatory proteins, intermediary metabolism and respiration, PE/PPE, cell wall and cell processes). Conclusions . We developed a simple method based on real-time PCR to detect clinically significant MDR and hypervirulent Beijing 14717-15-cluster. Most of the identified cluster-specific mutations were previously unreported and could potentially be associated with increased pathogenic properties of this hypervirulent M. tuberculosis strain. Further experimental study to assess the pathobiological role of these mutations is warranted.

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Possible Mechanisms of Self-Regulation of Parasitic Systems in the Biogeocenosis

et al. 2018

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ОбоснованиеВ эпидемиологии традиционно принято изолированно рассматривать эпидемический процесс отдельных инфекций. Между тем, как известно, в человеческой популяции одновременно циркулируют и вызывают заболевания у людей множество патогенных микроорганизмов. Поэтому вполне естественен вопрос: развивается ли эпидемический процесс каждой инфекции автономно или взаимосвязан с эпидемическими процессами других инфекционных болезней? Если связи между различными возбудителями существуют, то каким образом они реализуются и как отражаются на развитии эпидемического процесса? Спектр научных исследований, касающийся данной стороны вопроса, относительно ограничен, однако это направление привлекает, особенно в последние годы, все большее внимание ученых [1−11]. О необходимости интеграционного подхода к изучению эпидемиологии инфекционных болезнейПо-видимому, одним из первых, кто обосновал необходимость рассмотрения эпидемического процесса как единого целого явления -одновременного распространения различных инфекций и наличие всеобщих согласованных закономерностей совместного их распространения,The current epidemiological literature mainly presents the mechanisms of self-regulation of a single parasitic system influenced by natural and social factors. At the same time, epidemiology traditionally considers particularly the epidemic process of individual infections. In the human population however, many pathogenic microorganisms circulate and cause diseases in humans simultaneously; nevertheless the possibility of interactions between the various parasitic systems included in biogeocenosis and the influence of the considered interrelation on the development of the epidemic process and its manifestations is not taken into account generally. The presented study basing on the analysis of literary publications discusses possible mechanisms causing processes of self-regulation of parasitic systems in the conditions of biogeocenosis and, primarily, the integrative-competitive relations that develop between them as the leading regulating force. Therefore the following position is justified: regulatory processes in one parasitic system occur when influenced by self-regulation processes in biogeocenosis as a whole in response to the influence of both external and internal factors. Ultimately, the authors associate tendencies in the incidence of individual nosological forms, transformation of the structure of infectious pathology in different time periods, and some other manifestations of the epidemic process with the self-adaptation of ecosystems. Тихоокеанский государственный медицинский университет, Владивосток, Российская Федерация О возможных механизмах саморегуляции паразитарных систем в биогеоценозе В современной эпидемиологической литературе в основном обсуждаются механизмы саморегуляции отдельно взятой паразитарной системы под влиянием природных и социальных факторов. При этом в эпидемический процесс отдельных инфекций принято рассматривать изолированно. Однако в человеческой популяции одновременно циркулируют и вызывают заболев...

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Molecular-Genetic Features of Tuberculosis in Mongolia and in Russian Bordering Regions

Cited by 6 publications

References 4 publications

Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia

Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia

Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster

Possible Mechanisms of Self-Regulation of Parasitic Systems in the Biogeocenosis

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