Molecular Genetic Findings in Prader-Willi Syndrome

Stamm, Stefan; Butler, Merlin G.

doi:10.1007/978-3-030-98171-6_2

Cited by 1 publication

(4 citation statements)

References 165 publications

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“…Ethical difficulties, established methodology, the requirement for sufficient dosage, and long-term safety evaluations are just a few of the hurdles the sector must face. To traverse these hurdles and progress umbilical cord stem cell treatment as a possible breakthrough in the management of Prader-Willi Syndrome, researchers, medical experts, and regulatory agencies will need to work together indefinitely (Stamm, et , al , 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Stem cell therapy will need to be studied further and used with caution in order to reach its full potential and usher in a new age of treatment for these challenging and complex disorders. The pursuit of improvements in stem cell treatment is a critical first step in satisfying the unmet needs of persons suffering from the complex disorders Prader-Willi Syndrome (PWS) and Autism Spectrum Disorder (ASD) (Stamm, et , al , 2022). Preliminary and current research into umbilical cord stem cell treatment for PWS shows some potential for a more comprehensive therapeutic approach.…”

Section: Discussionmentioning

confidence: 99%

“…Prader-Willi Syndrome (PWS) is a rare, severe genetic disorder that may cause a number of behavioural, mental, and physical difficulties (Liang, 2020). (Stamm, et , al , 2022)…”

Section: Syndrome Of Prader-willi Syndrome As a Severe Genetic Disordermentioning

confidence: 99%

“…The stem cells of umbilical cord have enough capability to develop into a wide amount of cells, govern immunological responses, and release bioactive substances that aid in tissue repair and regeneration. This distinguishes them as a possible solution to PWS's many problems (Stamm, et , al , 2022). The aim of this research is to offer an overview of the available body of knowledge on Prader-Willi syndrome treatment utilizing umbilical cord stem cells.…”

mentioning

confidence: 99%

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Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

Susanti Vinsk,

Cinta Vinski

2023

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This abstract summarises the studies on the use of umbilical cord stem cells to treat Prader-Willi syn- drome. Among the various stem cells found in the umbilical cord, hematopoietic and mesenchymal stem cells may create bioactive molecules that aid in tissue repair and regeneration, control immunological responses, and give birth to a variety of cell types. Because of this, they present a feasible option for treating the multidisciplinary character of PWS. Preclinical research on PWS animal models has shown promising outcomes, with umbilical cord stem cell transplantation improving metabolic disorders, hy- hypothalamic function, and general behavior. It has been investigated if immunological regulation, trophic support, and paracrine signaling are among the factors that promote stem cell therapeutic potential. Several clinical studies employing umbilical cord stem cells to treat PWS are now underway, and the findings should aid in assessing the advantages and disadvantages of using this approach on patients. The preliminary evidence is encouraging, since some trial participants improved in hyperphagia, mus- cular tone, and cognitive ability. Although the use of umbilical cord stem cells as a PWS treatment has shown some promise, further study is required to determine its long-term safety, optimal dose, and ongoing effectiveness. A variety of key elements, such as ethical issues, regulatory frameworks, and the availability of standardized stem cell products, will have a considerable impact on the future development of this treatment technique. SD is a disease known as a neurodevelopmental problem represented through problems with social communication, sensor sensitivity, and repetitive behaviors. Despite years of study, therapy options for autism spectrum disorder (ASD) remain relatively limited. As regenerative medicine has improved, stem cell treatment has been investigated as a novel therapeutic option for the underlying neurological disorders that underpin ASD. The development, possible methods, and potential uses of stem cell treatment for autistic children are discussed in this article.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Prader-Willi Syndrome (PWS) is a rare, severe genetic disorder that may cause a number of behavioural, mental, and physical difficulties (Liang, 2020). (Stamm, et , al , 2022)…”

Section: Syndrome Of Prader-willi Syndrome As a Severe Genetic Disordermentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

Susanti Vinsk,

Cinta Vinski

2023

View full text Add to dashboard Cite

show abstract

Molecular Genetic Findings in Prader-Willi Syndrome

Cited by 1 publication

References 165 publications

Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

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