Molecular-Genetic Mechanisms of Caries Development

Udina, I. G.; Гуленко, О. В.

doi:10.1134/s1022795418040154

Cited by 7 publications

(5 citation statements)

References 69 publications

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“…Studies on children with congenital malformations of the orofacial area, e.g., clefts of the lips and the palate, accompanied by various defects of dental development and other pathologies, e.g., with malformations of the central nervous system, are of particular interest. A low level of hygiene is associated with the pathologies mentioned [2]. Therefore, consideration of the immune and immunomodulatory mechanisms of the immune response leading to the development of caries in these groups is relevant.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Genetic Study on VNTR-polymorphism of Two Cytokine Genes Antagonist of the Receptor of Interleukin 1 (rs2234663) and Interleukin 4 (rs8179190) Associated with Dental Caries in Children

Udina¹,

Vasiliev²,

Volobuyev³

et al. 2021

OBM Genet

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In this study, we investigated VNTR polymorphisms in intron 2 of the IL1RN gene (rs2234663) and intron 3 of the IL4 gene (rs8179190) related to the development of caries in school children (N = 196) with mixed bite dentition from Krasnodarskii Krai. The genotypes A1/A1 and L/L (L-“long” alleles) (rs2234663) provided resistance to the most intensive form of dental caries. The groups of children with DFC (decompensated form of caries) were significantly different from the pooled group SFC (subcompensated form of caries) and CFC (compensated form of caries) (and healthy children) for two genotypes: A1/A1 (OR = 0.37, p = 0.015, 95% CI: 0.17-0.84) and L/L (OR = 0.38. p = 0.020, 95% CI: 0.17-0.88). In locus rs8179190 (IL4), a rare allele with a single repeat (70 bp)-P3 (113 bp) was observed. For VNTR polymorphisms of rs8179190, association with the most intensive form of caries was found only for two-locus genotypes with rs2234663. The results suggested that the studied cytokine markers and the ratio of the pro-inflammatory to anti-inflammatory cytokines might be involved in the development of the most intensive form of caries.

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Section: Discussionmentioning

confidence: 99%

“…Fermentable sugars facilitate the development of the disease. Genetic and environmental factors and the resistance of teeth influence the formation of lesions, which depends on the duration of exposure to disease-causing factors [2]. The risk of dental caries is predetermined by the genetic and immune peculiarities of an individual.…”

Section: Introductionmentioning

confidence: 99%

Molecular Genetic Study on VNTR-polymorphism of Two Cytokine Genes Antagonist of the Receptor of Interleukin 1 (rs2234663) and Interleukin 4 (rs8179190) Associated with Dental Caries in Children

Udina¹,

Vasiliev²,

Volobuyev³

et al. 2021

OBM Genet

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“…The literature reports several genes associated with enamel formation features: amelogenin (AMELX), enamelin (ENAM), KLK-4, enamelysin or MMP-20, the ameloblastin gene, and recently identified DLX3, FAM83H, WDR72, and SLC4A4. 28 The ENAM encodes the matrix proteins involved in the formation of enamel; it is located on chromosome 4, in position 71859495-71777517 from NM_031889 sequence. Enamelin is involved in enamel formation and is incorporated in crystals formed in enamel prisms and between them.…”

Section: Tgf-β1influence Enam Genementioning

confidence: 99%

“…Physical properties depend on enamel gene expression along with the amelogenin and ameloblastin genes. 28 Mutations in the development regulating gene (TGF-β1) are associated with dental development defects, at the morphodifferentiation stage is the stage of tooth formation that can cause an enamel defect. 29 ENAM gene mutations in local hypoplastic Amelogenesis Imperfecta show that different mutations in the enamelin gene can lead to different clinical variants of local hypoplastic enamel and are smooth and thin from relatively small local defects to serious types of hypoplasia.…”

Section: Tgf-β1influence Enam Genementioning

confidence: 99%

ENAM Gene Mutation Factor in Amelogenesis Imperfecta

Apriani¹,

Sembiring²,

Suryatmojo³

et al. 2019

sod

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Amelogenesis Imperfecta (AI) is an abnormal disease that occurs in hard tissue of teeth. Clinical features of Amelogenesis Imperfecta look like immature enamel that looks like hypomaturation. The etiology of AI is influenced by the TGF-?1 factor which is disturbed during the formation and development of enamel, one of which is caused by the presence of ENAM gene mutations. Further research on genetic history in the family and biomineralization of the formation of enamel important to be developed later.

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“…It typifies the way that the pathogenesis of caries is understood nowadays. 1 caries is influenced by genetic markers linked to early childhood caries (ECC). 3 Utilizing population association studies, familial analysis based on triads (father, mother, and child), genome-wide association studies (GWAS), and meta-analysis, the genetic loci linked to dental caries have been explored.…”

Section: Introductionmentioning

confidence: 99%

Role of Genetic Markers in Dental Caries: A Literature Review

Sharma,

Bhandary

2023

Journal of Health and Allied Sciences NU

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Introduction This article reviews the literature on the role of genetic markers in the initiation and progression of dental caries and provides a modern understanding of the disease etiology. Dental caries is a complex, chronic, multifactorial disease which is influenced by genetic, environmental, and social factors. Identification of genetic risk factors will help screen and identify susceptible patients to better understand the contribution of genes in caries etiopathogenesis to formulate various diagnostic and novel therapeutic approaches in the management of the disease. Materials and Methods Innovations and ideas were retrieved based on the literature in journals and textbooks indexed in PubMed, Google Scholar, Scopus, and Web of Science database. The theories obtained are then summarized into a continuous series; thus, readers can more easily understand the ideas and innovations offered. Results Through interactions of the involved gene products, genetic markers have been constructed and provide us with insights into the molecular mechanisms underlying caries. There can also be gene–gene interactions or gene–environment interactions that create epigenetic effects that all possibly contribute to caries risk and resistance. A variety of caries markers have been identified, including genes affecting salivary flow rates and composition, tooth formation genes, as well as immune genes. Conclusion Information derived from various diverse studies will provide new tools to target individuals and/or populations for a more efficient and effective implementation of new preventive measures and diagnostic and novel therapeutic approaches in the management of dental caries.

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Molecular-Genetic Mechanisms of Caries Development

Cited by 7 publications

References 69 publications

Molecular Genetic Study on VNTR-polymorphism of Two Cytokine Genes Antagonist of the Receptor of Interleukin 1 (rs2234663) and Interleukin 4 (rs8179190) Associated with Dental Caries in Children

Molecular Genetic Study on VNTR-polymorphism of Two Cytokine Genes Antagonist of the Receptor of Interleukin 1 (rs2234663) and Interleukin 4 (rs8179190) Associated with Dental Caries in Children

ENAM Gene Mutation Factor in Amelogenesis Imperfecta

Role of Genetic Markers in Dental Caries: A Literature Review

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