Molecular genetic techniques for gains and losses of genomic material in a case of acute myeloid leukemia

Santos, Mauren Fernanda Moller dos; Lara, Camila Clozato; Velloso, Elvira Deolinda Rodrigues Pereira

doi:10.1016/j.bjhh.2017.06.001

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Combination Of Copy Number Aberrations Somat-1

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2019

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“…DISCUSSION The application of MLPA in the evaluation of acute leukemia has been described in several studies performed in relatively small patient cohorts. [10][11][12][13][14] We evaluated CNAs by the MLPA method in patients with AML, providing the first such data in a representative Romanian population. Of the 283 patients with AML, the presence of CNAs was identified in 90 samples.…”

Section: Combination Of Copy Number Aberrations Somat-mentioning

confidence: 99%

See 1 more Smart Citation

Presence of copy number aberration and clinical prognostic factors in patients with acute myeloid leukemia: an analysis of effect modification

Bănescu¹,

Tripon²,

Crauciuc³

et al. 2019

Polish Archives of Internal Medicine

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and low survival rates. 1,2 Chromosomal abnormalities and gene mutations are important prognostic factors in AML, but also in other types of leukemia, such as chronic lymphocytic leukemia (CLL). 3,4 INTRODUCTION Acute myeloid leukemia (AML), the most common acute leukemia in adults, is a heterogeneous, complex, and dynamic disease, characterized by multiple somatically acquired genetic events, progression over time,

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Section: Combination Of Copy Number Aberrations Somat-mentioning

confidence: 99%

“…A few MLPA studies have been performed in patients with AML, but they included a small number of samples. 10,11,16 Recurrent CNAs might represent an important prognostic marker in AML and might guide clinical decision making, especially in AML. Their identification by molecular methods could be helpful in cases with inconclusive cytogenetic analysis.…”

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confidence: 99%