Molecular genetics of febrile seizures

Association study between interleukin 1β gene and epileptic disorders: a HuGe review and meta-analysis

“…However, prospective studies failed to confirm this relationship. 31 Because it is well known that a rapid rise of fever or high body temperatures during an infectious disease can trigger seizures in individuals who are prone to FS, 31 genes encoding proteins involved in the regulation of inflammatory processes and fever are plausible candidate genes in the elucidation of the molecular mechanisms of FS and TLE. Inflammation may also be involved in secondary epileptogenesis in TLE.…”

Novel susceptibility locus at chromosome 6q16.3-22.31 in a family with GEFS+

“…4,15 In addition, linkage studies have identified 7 genomic regions likely to harbor genes increasing risk for GEFSϩ and 5 regions likely to harbor genes increasing risk for FS (table 1). [16][17][18][19][20][21][22][23][24][25][26] Two loci originally described as FS loci (FEB3 and FEB4) were reported in pedigrees best classified as GEFSϩ due to phenotypes beyond typical FS.…”

Association Between IL1B and SCN1A Polymorphism and Febrile Seizures in Children in Siberia

“…IL1B modulates cell proliferation, induces other cytokines, (10) and can serve as an endogenous pyrogen. (11) It is important to note that bacterial lipopolysaccharides stimulate production of IL1B, not only by macrophages on the periphery, but also by microglia, astrocytes and some neurons of the CNS.…”

“…(3,9) Based on these findings, one can suppose that polymorphisms of IL1B and SCN1A genes, encoding the proinflammatory cytokine IL1B and SCN1A, respectively, are one of the factors that can help determine FS development and further help in finding a new way of FS treatment. (10) The aim of the study was the investigation of frequency for high-producing alleles of the IL1B-and SCN1A genes polymorphisms in children with FS.…”