Molecular Genetics of Glioblastomas

Renault, Ilana Zalcberg; Golgher, Denise

doi:10.1016/j.nic.2014.09.007

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Previous studies mentioned, the occurrence of GBM is considerably high in different populations. [1] But because this tumor is the most fatal primary tumor of brain tissue, nearly all the patients die in the 1 st year after diagnosis. Because of this matter, the prevalence of GBM is low.…”

Section: Discussionmentioning

confidence: 99%

“…Glioblastoma multiform (GBM) as the most fatal malignant primary tumor of CNS, consists 54% of all Gliomas. [1] This tumor can originate from normal brain cells or develop from an existing low-grade astrocytoma. [2] There are several possible risk factors such as prior exposure to radiotherapy for GBM; however genetic background could be considered as an important predisposing factor in GBM.…”

Section: Introductionmentioning

confidence: 99%

“…[3] The current treatments of GBM only provides a 12–18 month survival period postdiagnosis. [1] In spite of surgical treatment and chemotherapy, almost all GBM patients undergo tumor recurrence. [4] This necessitates more investigation to define molecular pathogenesis of this malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population

et al. 2018

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Background:Glioblastoma multiform (GBM) is the most common and most malignant of the glial tumors that begins primarily in brain tissue. Genetic background could be considered as an important predisposing factor in GBM. Autocrine motility factor receptor (AMFR) is a cytokine receptor that participates in a lot of physiologic and pathologic processes like: Cellular motility and metastasis. So, it seems that this protein has an essential role in pathophysiology of several cancers and could be a potential diagnostic and or therapeutic target in GBM. The aim of this study is to investigate the association of AMFR (rs2440472, rs373191257) gene polymorphism and GBM in a representative Iranian population.Materials and Methods:This study includes 81 cases of GBM and 117 control subjects. After DNA extraction, polymerase chain reaction - high resolution melting reaction was performed. For each single nucleotide polymorphisms, 12 samples were selected for sequencing. Data was analyzed using Chi-square test and Logistic regression.Results:For rs2440472, frequency of GG genotype in the case group was increased compared to the control group (51.9% vs. 34.2% respectively, P = 0.013). After adjusting for sex and age by logistic regression our results were the same (P = 0.017, odds ratio = 2.056). Allelic frequencies for rs2440472 among cases and controls were not significantly different (P = 0.058). For rs373191257, genotypic and allelic frequencies were not significantly different between two groups.Conclusion:Our results showed the possible association between the AMFR rs2440472 gene polymorphism with susceptibility to GBM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population

et al. 2018

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“…Intratumoral heterogeneity creates a major challenge in the treatment of GBM. Heterogeneity has been detected among tumors from different patients, yet molecular analysis of patient-derived GBM tissue has shown genetic diversity within regions of individual tumors as well [ 155 , 156 , 157 ]. Single-cell RNA sequencing and integrated genomic analysis of GBM tissues have shown unique transcriptional programs within individual tumors and clinically relevant subtypes [ 150 , 158 ].…”

Section: Mechanisms Of Gbm Radioresistancementioning

confidence: 99%

Radioresistance in Glioblastoma and the Development of Radiosensitizers

Ali

Oliva

Noman

et al. 2020

Cancers

108

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Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously investigated over the past several years, but the complex interaction of the cellular molecules and signaling pathways involved in radioresistance remains incompletely defined. A clinically effective radiosensitizer that overcomes radioresistance has yet to be identified. In this review, we discuss the current status of radiation treatment in GBM, including advances in imaging techniques that have facilitated more accurate diagnosis, and the identified mechanisms of GBM radioresistance. In addition, we provide a summary of the candidate GBM radiosensitizers being investigated, including an update of subjects enrolled in clinical trials. Overall, this review highlights the importance of understanding the mechanisms of GBM radioresistance to facilitate the development of effective radiosensitizers.

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