Molecular Genetics of Lung and Pleural Neoplasms

Cagle, Philip T.; Jagirdar, Jaishree; Popper, Helmut

doi:10.1007/978-0-387-72114-9_2

Cited by 3 publications

(1 citation statement)

References 1,961 publications

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“…In typical carcinoid tumors, which account for 70-90% of all carcinoid tumors and tend to settle in the center, the number of mitoses is less than 2 in 10 HPF’s, with no necrosis. The number of mitosis in atypical carcinoid tumors is between 3 and 9 in 10 HPF’s, and focal necrosis can be detected in such tumors ( 1 , 12 ). No significant cytological atypia, necrosis or elevated mitotic activity (<2/10 HPF) was observed in our case.…”

Section: Discussionmentioning

confidence: 99%

Bronchial carcinoid tumors with massive osseous metaplasia: a case report and review of the literature

Özşen

Yalçinkaya²,

Akyıldız³

et al. 2019

TJPATH

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Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. A 61-year-old male patient underwent surgery and microscopic examination of the specimen revealed an anastomosing trabecular bony structure among the nests of tumor cells with round nucleus, granular chromatin, and large eosinophilic cytoplasm. Our case has been deemed worthy of being presented as bronchial carcinoid tumor with exaggerated osseous metaplasia.

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Section: Discussionmentioning

confidence: 99%

Bronchial carcinoid tumors with massive osseous metaplasia: a case report and review of the literature

Özşen

Yalçinkaya²,

Akyıldız³

et al. 2019

TJPATH

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Squamous Cell Carcinoma, Lung

Wallace¹

2018

Encyclopedia of Pathology

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Revolution in Lung Cancer: New Challenges for the Surgical Pathologist

Cagle¹,

Allen²,

Đačić³

et al. 2011

Archives of Pathology &Amp; Laboratory Medicine

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Context—Traditionally, lung cancer has been viewed as an aggressive, relentlessly progressive disease with few treatment options and poor survival. The traditional role of the pathologist has been primarily to differentiate small cell carcinoma from non–small cell carcinoma on biopsy and cytology specimens and to stage non–small cell carcinomas that underwent resection. In recent years, our concepts of lung cancer have undergone a revolution, including (1) the advent of successful, new, molecular-targeted therapies for lung cancer, many of which are associated with specific histologic cell types and subtypes; (2) new observations on the natural history of lung cancer derived from ongoing high-resolution computed tomography screening studies and recent histologic findings; and (3) proposals to revise the classification of lung cancers, particularly adenocarcinomas, in part because of the first 2 developments. Objective—To summarize the important, new developments in lung cancer, emphasizing the role of the surgical pathologist in personalized care for patients with lung cancer. Data Sources—Information about the new developments in lung cancer was obtained from the peer-review medical literature and the authors' experiences. Conclusions—For decades, we have perceived lung cancer as a relentlessly aggressive and mostly incurable disease for which the surgical pathologist had a limited role. Today, surgical pathologists have an important and expanding role in the diagnosis and treatment of lung cancer, and it is essential to keep informed of new advances.

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Molecular Genetics of Lung and Pleural Neoplasms

Cited by 3 publications

References 1,961 publications

Bronchial carcinoid tumors with massive osseous metaplasia: a case report and review of the literature

Bronchial carcinoid tumors with massive osseous metaplasia: a case report and review of the literature

Squamous Cell Carcinoma, Lung

Revolution in Lung Cancer: New Challenges for the Surgical Pathologist

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