Molecular genetics of prostate cancer

Abate‐Shen, Cory; Shen, Michael M.

doi:10.1101/gad.819500

Cited by 606 publications

(543 citation statements)

References 225 publications

(260 reference statements)

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“…Only 1 of 8 samples (N1) of normal prostate (surgically removed because of bladder carcinoma) grew in culture, whereas we successfully derived two cell strains from benign prostatic hyperplasia (C10 and C17) and one from a contralateral normal tissue characterized by the presence of prostate intraepithelial neoplasia (C16sx). Cultures from normal/hyperplastic tissue (N1, C10, C17, and C16sx) and cancer had similar growth rate (10,11). Importantly, all cultures had limited life span (20-25 population doublings) and similar cell morphology, as described (12).…”

Section: Isolation Of Prostate Epithelial Culturesmentioning

confidence: 95%

Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer

Nanni¹,

Priolo

Grasselli

et al. 2006

Molecular Cancer Research

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Section: Isolation Of Prostate Epithelial Culturesmentioning

confidence: 95%

Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer

Nanni¹,

Priolo

Grasselli

et al. 2006

Molecular Cancer Research

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“…The etiologic agents that contribute to the development of human prostatic diseases such as benign prostate hyperplasia (BPH) and prostate cancer remain largely unknown (1)(2)(3)(4). Studies have suggested close links among certain infections of the prostate, chronic inflammation, and the development of inflammation-associated prostatic diseases (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

Ponomareva

Liu

Duan

et al. 2013

Molecular Cancer Research

104

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Close links have been noted between chronic inflammation of the prostate and the development of human prostatic diseases such as benign prostate hyperplasia (BPH) and prostate cancer. However, the molecular mechanisms that contribute to prostatic inflammation remain largely unexplored. Recent studies have indicated that the IFN-inducible AIM2 protein is a cytosolic DNA sensor in macrophages and keratinocytes. Upon sensing DNA, AIM2 recruits the adaptor ASC and pro-CASP1 to assemble the AIM2 inflammasome. Activation of the AIM2 inflammasome cleaves pro-interleukin (IL)-1b and pro-IL-18 and promotes the secretion of IL-1b and IL-18 proinflammatory cytokines. Given that human prostatic infections are associated with chronic inflammation, the development of BPH is associated with an accumulation of senescent cells with a proinflammatory phenotype, and the development of prostate cancer is associated with the loss of IFN signaling, the role of AIM2 in mediating the formation of prostatic diseases was investigated. It was determined that IFNs (a, b, or g) induced AIM2 expression in human prostate epithelial cells and cytosolic DNA activated the AIM2 inflammasome. Steady-state levels of the AIM2 mRNA were higher in BPH than in normal prostate tissue. However, the levels of AIM2 mRNA were significantly lower in clinical tumor specimens. Accordingly, constitutive levels of AIM2 mRNA and protein were lower in a subset of prostate cancer cells as compared with BPH cells. Further, the cytosolic DNA activated the AIM2 inflammasome in the androgen receptor-negative PC3 prostate cancer cell line, suggesting that AIM2-mediated events are independent of androgen receptor status.

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“…There is an urgent need for appropriate diagnostic and prognostic markers, in addition to the established serum protease prostate-specific antigen (PSA), allowing an early diagnosis and the prediction of the clinical behavior of individual tumors. Although the involvement of certain genes and of chromosomal aberrations in prostate carcinogenesis has been suggested (2,3), the molecular mechanisms underlying the initiation and progression of prostate cancer are only poorly understood.…”

mentioning

confidence: 99%

Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer

Hermani¹,

Heß

Servi³

et al. 2005

Clinical Cancer Research

225

158

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Purpose: S100 proteins comprise a family of calcium-modulated proteins that have recently been associated with epithelial tumors. We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate adenocarcinomas and in prostatic intraepithelial neoplasia. Experimental Design:Tissue specimens of 75 patients with organ-confined prostate cancer of different grades were analyzed by immunohistochemistry for expression of S100A8, S100A9, and RAGE. In addition, in situ hybridization of S100A8 and S100A9 was done for 20 cases. An ELISA was applied to determine serum concentrations of S100A9 in cancer patients compared with healthy controls or to patients with benign prostatic hyperplasia (BPH). Results: S100A8, S100A9, and RAGE were up-regulated in prostatic intraepithelial neoplasia and preferentially in high-grade adenocarcinomas, whereas benign tissue was negative or showed weak expression of the proteins. There was a high degree of overlap of S100A8 and S100A9 expression patterns and of S100A8 or S100A9 and RAGE, respectively. Frequently, a gradient within the tumor tissue with an increased expression toward the invaded stroma of the prostate was observed. S100A9 serum levels were significantly elevated in cancer patients compared with BPH patients or healthy individuals. Conclusion: Our data suggest that enhanced expression of S100A8, S100A9, and RAGE is an early event in prostate tumorigenesis and may contribute to development and progression or extension of prostate carcinomas. Furthermore, S100A9 in serum may serve as useful marker to discriminate between prostate cancer and BPH.

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Molecular genetics of prostate cancer

Cited by 606 publications

References 225 publications

Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer

Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer

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