Molecular genetics of substance use disorders: An umbrella review

López-Léon, Sandra; González-Giraldo, Yeimy; Wegman-Ostrosky, Talía; Forero, Diego A.

doi:10.1016/j.neubiorev.2021.01.019

Cited by 46 publications

(26 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding accorded with some studies [ 17 , 18 ], but it was inconsistent with others [ 19 – 21 ]. In their umbrella review based on more than 150 meta-analyses on substance use disorders, Lopez-Leon et al [ 22 ] reported that the BDNF gene had an odds ratio higher than 2 for methamphetamine dependence, but not for alcohol dependence. Another meta-analysis showed that 8 studies on rs6265 and alcoholism were inconsistent [ 23 ], and the discrepancies were mainly caused by the differences between European and Asian races.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with BDNF Gene Val66Met Polymorphism in Alcohol Dependence

Zhang

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

Background In a previous study, we reported that pro-brain-derived neurotrophic factor (proBDNF) was involved in the pathology of alcohol dependence, and the single-nucleotide polymorphism (SNP) Val66Met was located at the prodomain of the brain-derived neurotrophic factor gene ( BDNF ). This polymorphism has been reported to affect intracellular trafficking and activity-dependent secretion of BDNF. Our present research investigated the relationships between the BDNF Val66Met polymorphism and the plasma levels of proBDNF and mature brain-derived neurotrophic factor (mBDNF) in patients with alcohol dependence. Material/Methods The BDNF gene Val66Met polymorphism was genotyped in 59 alcohol-dependent patients and 37 age- and sex-matched controls, and the plasma levels of proBDNF and mBDNF were assessed by enzyme-linked immunosorbent assay in all participants. Results No association was found between the BDNF gene Val66Met polymorphism and alcohol dependence ( P >0.05). In comparison with the control group, the level of plasma proBDNF in the alcohol-dependence group was notably increased ( Z =−2.228, P =0.026), while the level of mBDNF was remarkedly decreased ( Z =−2.014, P =0.044). In the alcohol-dependence group, significant associations were not found between the Val66Met polymorphisms and proBDNF and mBDNF plasma levels ( P >0.05). The plasma level of proBDNF was positively correlated with the average daily alcohol consumption in the last month ( r =0.344, P =0.008) and drinking history ( r =0.317, P =0.014), while the plasma level of mBDNF had negative effects ( r =−0.361, P =0.005, with the average daily alcohol consumption; r =−0.427, P =0.001, with drinking history). Conclusions The BDNF gene Val66Met polymorphism does not appear to affect the secretion of proBDNF and mBDNF in Chinese patients with alcohol dependence. Furthermore, this study reconfirmed that the plasma levels of proBDNF and mBDNF were correlated with the average daily alcohol consumption in the last month and with drinking history.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with BDNF Gene Val66Met Polymorphism in Alcohol Dependence

Zhang

et al. 2021

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…We have, thus far, discussed the role of DA in various diseases from a systems and neural circuit perspective. However, as further evidence, DA-related genes are implicated as molecular modulators or risk factors for neuropsychiatric diseases such as schizophrenia and addiction [221][222][223][224]. Many of these implicated genes are involved in DA recycling and thus DA homeostasis.…”

Section: Dopamine System Genes and Neuropsychiatric Diseasementioning

confidence: 98%

Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease

Chen,

Kim

et al. 2021

Biomedicines

View full text Add to dashboard Cite

Dopamine (DA) is a behaviorally and clinically diverse neuromodulator that controls CNS function. DA plays major roles in many behaviors including locomotion, learning, habit formation, perception, and memory processing. Reflecting this, DA dysregulation produces a wide variety of cognitive symptoms seen in neuropsychiatric diseases such as Parkinson’s, Schizophrenia, addiction, and Alzheimer’s disease. Here, we review recent advances in the DA systems neuroscience field and explore the advancing hypothesis that DA’s behavioral function is linked to disease deficits in a neural circuit-dependent manner. We survey different brain areas including the basal ganglia’s dorsomedial/dorsolateral striatum, the ventral striatum, the auditory striatum, and the hippocampus in rodent models. Each of these regions have different reported functions and, correspondingly, DA’s reflecting role in each of these regions also has support for being different. We then focus on DA dysregulation states in Parkinson’s disease, addiction, and Alzheimer’s Disease, emphasizing how these afflictions are linked to different DA pathways. We draw upon ideas such as selective vulnerability and region-dependent physiology. These bodies of work suggest that different channels of DA may be dysregulated in different sets of disease. While these are great advances, the fine and definitive segregation of such pathways in behavior and disease remains to be seen. Future studies will be required to define DA’s necessity and contribution to the functional plasticity of different striatal regions.

show abstract

“…Generational continuity in the use of substances has gained attention for several decades (1)(2)(3)(4). There is growing evidence showing that several biopsychosocial factors may contribute to heightened substance use risk in children of parents with substance use disorders (SUDs) (5)(6)(7), indicating that both genetic (8)(9)(10), and environmental factors (11,12) play an important role in the heightened susceptibility to and manifestation of SUDs later in life (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“I Grew Up Amidst Alcohol and Drugs:” a Qualitative Study on the Lived Experiences of Parental Substance Use Among Adults Who Developed Substance Use Disorders Themselves

et al. 2022

View full text Add to dashboard Cite

Experiencing parental substance use (PSU) has been associated with a heightened risk of developing substance use disorders (SUDs) in offspring. The primary goal of this study was to explore perspectives of adult children with lived experience of PSU who also developed SUDs themselves through first-hand experience. This study was conducted in Flanders (Belgium). A qualitative exploratory research design was applied. Seventeen semi-structured interviews were conducted with adult children of parents with SUDs (range: 29–48 years) who themselves had developed SUDs. All interviews were audio-taped and transcribed verbatim. Three overarching themes emerged through thematic analysis: 1) loneliness and neglect in childhood; 2) stigma and the self; and 3) the role of social connection in substance use and recovery. The narratives highlighted the central role of feelings of loneliness, isolation and belonging among children of parents with SUDs in childhood and adulthood. Increasing public awareness on the impact of PSU on children and accessible support is needed to overcome stigma and remove barriers to social inclusion for children of parents with SUDs. Findings may prove valuable in informing policy, program and treatment development aimed at breaking maladaptive intergenerational cycles.

show abstract

Molecular genetics of substance use disorders: An umbrella review

Cited by 46 publications

References 57 publications

Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with BDNF Gene Val66Met Polymorphism in Alcohol Dependence

Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with BDNF Gene Val66Met Polymorphism in Alcohol Dependence

Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease

“I Grew Up Amidst Alcohol and Drugs:” a Qualitative Study on the Lived Experiences of Parental Substance Use Among Adults Who Developed Substance Use Disorders Themselves

Contact Info

Product

Resources

About