2004
DOI: 10.1007/0-387-21567-0_2
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Molecular Genetics of Vestibular Organ Development

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Cited by 15 publications
(30 citation statements)
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References 194 publications
(208 reference statements)
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“…Indeed, lack of morphogenetic segregation in lamprey was recently attributed to the absence of Otx1 (Hammond and Whitfield, 2006) as previously suggested . Data on Otx1 mutants as well as others (see below) suggest that segregation and morphogenesis are linked, but the molecular basis of this link is not completely clear (Chang et al, 2004a, Chang et al, 2004b, Fritzsch et al, 2006b, Fritzsch and Wake, 1988. More genes that function like Otx genes are needed to fully understand what drives sensory epithelial segregation; in particular the segregation of canal cristae from gravistatic organs.…”
Section: Evolution Of the Vertebrate Ear Through Segregation Of Epithmentioning
confidence: 97%
See 1 more Smart Citation
“…Indeed, lack of morphogenetic segregation in lamprey was recently attributed to the absence of Otx1 (Hammond and Whitfield, 2006) as previously suggested . Data on Otx1 mutants as well as others (see below) suggest that segregation and morphogenesis are linked, but the molecular basis of this link is not completely clear (Chang et al, 2004a, Chang et al, 2004b, Fritzsch et al, 2006b, Fritzsch and Wake, 1988. More genes that function like Otx genes are needed to fully understand what drives sensory epithelial segregation; in particular the segregation of canal cristae from gravistatic organs.…”
Section: Evolution Of the Vertebrate Ear Through Segregation Of Epithmentioning
confidence: 97%
“…FGF10 is known to interact with BMP4, which appears in the early development of the Drosophila mechanosensors and is part of the upstream regulation of cell fate determination. In the mammalian inner ear, Fgf10 and Bmp4 are both expressed in the presumptive sensory epithelia and they interact during canal morphogenesis (Chang et al, 2004b). Further, Bmp4 has been shown to reduce the size of prosensory patches, while Noggin, a BMP-inhibitor, increases the prosensory domain, thereby increasing the area of Fgf10 expression (Pujades et al, 2006).…”
Section: Evolution Of the Vertebrate Ear Through Segregation Of Epithmentioning
confidence: 99%
“…The semicircular canals emerge initially as two epithelial protrusions or canal plates. The anterior and posterior semicircular canals are generated from the vertical canal plate, whereas the lateral semicircular canal develops from the horizontal canal plate (Martin and Swanson 1993;Chang et al 2004a). With the fusion of the opposing walls of the epithelial plates and resorption of the central portion, the three fluid-filled canals are formed.…”
mentioning
confidence: 99%
“…As the development of the ear progresses to the otocyst stage, the expression domains of these and other genes become confined to particular regions of the epithelium destined to give rise to specific inner ear structures (Fekete and Wu 2002). This refinement of gene expression within the otic vesicle is also dependent on extrinsic signals derived from neighboring tissues as evidenced by the growing number of mouse mutants exhibiting inner ear phenotypes that result from aberrant gene function in the neural tube and surrounding tissues (Chang et al 2004a). Previous work by our group and others described a role for Shh in promoting ventral otic fates Riccomagno et al 2002).…”
mentioning
confidence: 99%
“…Another category of inner ear phenotypes that is beyond the scope of this review are mutants with disrupted fluid homeostasis of the inner ear. These inner ear defects are often associated with engorgement or shrinkage of the membranous labyrinth due to fluid imbalance rather than problems in morphogenesis (Cowan et al, 2000, Everett et al, 2001, Chang et al, 2004b, Dravis et al, 2007. In summary, the continual discoveries of inductive signals and their downstream cascades of molecule events for inner ear formation will decode the formation of this complex organ and pave the way for design of strategies to improve hearing and vestibular disorders.…”
Section: Resultsmentioning
confidence: 99%