Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry

Abstract

Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity compared to rare alkaloids. Many synthetic approaches have been employed to hybridize the natural alkaloids in drug development. Click chemistry is a highly efficient and versatile reaction targeting specific areas, making it a valuable tool for creating complex natural products and diverse molecular structures. It has been used to create hybrid alkaloids that address their limitations and serve as potential drugs that mimic natural products. In this review, we highlight the recent advancements made in modifying alkaloids using click chemistry and their potential medicinal applications. We discuss the significance, current trends, and prospects of click chemistry in natural product-based medicine. Furthermore, we have employed computational methods to evaluate the ADMET properties and drug-like qualities of hybrid molecules.

Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives

“…Nitrogencontaining heterocycles are considered to have strong bioactivity and are very important in the field of medicinal chemistry and drug discovery [37][38][39][40]. A five-membered ring with three nitrogen and two carbon atoms called triazole has demonstrated anticancer activity [41]. The 1,3-dipolar cycloaddition reaction between alkyne and azide lead to the formation of a triazole moiety [42], a promising scaffold for the development of various potent anticancer agents [43][44][45].…”