Molecular Identification of 7 Human Papillomavirus Types in Recurrent Respiratory Papillomatosis

Abstract

These results show that RRP is caused by infection with HPV types 6 and 11 in addition to many other types, with no relationship between HPV type and clinical severity.

Clinical Course of Recurrent Respiratory Papillomatosis in Danish Children

“…6,7,9,12,13,27 However, 4 of these studies 6,9,12,27 identified cases from a single hospital, which may not represent the disease experience of the population. Armstrong et al 7 reported an estimate of 3.8 years in a large sample of patients with RP (N=399) enrolled over a 2-year period in a US-based national registry.…”

Four mutations in Epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRP

“…Perhaps these four mutations confer susceptibility to HPV of types other than 6 and 11. Indeed, it has been suggested that EV patients with malignant warts are more susceptible to HPV 5 or 8 [10,11] as opposed to RRP patients who are unable to clear disease caused by HPV 6 and/or 11 [12,13]. On the other hand, simply because we did not encounter any of the four previously identified mutations does not exclude the possibility that one or more of the mutations may rarely confer susceptibility to RRP.…”

Low frequency of human papillomavirus DNA in breast cancer tissue

“…Most of them not only reported broad ranges in sensitivity, but also recommended nested PCR to render better results. However, the method used in the present study has been validated and proved to be highly sensitive and specific in previous reports from our group [2,4,35] and taking into account that nested PCR is widely known as a contamination-prone method, we consider our technique to be reliable for HPV detection in breast cancer tissue. Data on Table 3 reveals an ample range of positivity, where the highest rate is reported by de Villiers, et al [25] (86.21%) in a population with breast cancer and histological features suggestive of HPV infection.…”