Molecular Identification of an IgE-Dependent Histamine-Releasing Factor

MacDonald, Susan; Rafnar, Thorunn; Langdon, Jacqueline M.; Lichtenstein, Lawrence M.

doi:10.1126/science.7542803

Cited by 353 publications

(252 citation statements)

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“…The first report on a functional association of TCTP appeared in 1995. Susan MacDonald and co-workers (Baltimore) identified an extracellular function of this protein as 'histamine-releasing factor' (HRF) present in biological fluids of allergic patients (MacDonald et al 1995). This discovery led to a series of studies exploring the extracellular signalling function of HRF/TCTP in allergic and inflammatory responses, as recently reviewed by Dr.…”

Section: The 'Translationally Controlled Tumour Protein Tctp': Names mentioning

confidence: 99%

“…In 1995, Susan Macdonald's group first described the presence of an 'IgE-dependent histamine-releasing factor (HRF)' in biological fluids of allergic patients, which was also produced by lymphocytes of atopic children (MacDonald et al 1995). The molecular characterisation revealed that this protein is identical to TCTP (or p21/p23).…”

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

“…Release of local signalling molecules from immune cells, triggered by extracellular TCTP/HRF. The focus of the initial publication, which identified TCTP as HRF, was on the IgE-dependent of histamine release in biological fluids from allergic patients (MacDonald et al 1995). However, a number of subsequent studies revealed that the 'scope' of TCTP/HRF as an extracellular 'signalling molecule' in immunological reactions is much wider, in that its activity is not IgE-dependent and that it is able to modulate the release of various cytokines in a number of different cell types involved in immune functions (MacDonald 2012a, b).…”

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

“…Antihistaminics and antidepressants. Based on the identification of TCTP as histamine-releasing factor HRF (MacDonald et al 1995), the Telerman laboratory tested a panel of antihistaminic drugs for their effect on human leukaemia and breast cancer cells (Tuynder et al 2004). Of these ones, hydroxyzine and promethazine displayed growth-inhibiting activity on these cells.…”

Section: Tctp As An Anticancer Targetmentioning

confidence: 99%

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The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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Section: The 'Translationally Controlled Tumour Protein Tctp': Names mentioning

confidence: 99%

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

Section: Tctp As An Anticancer Targetmentioning

confidence: 99%

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The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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“…En outre, des concentrations plasmatiques élevées d'anticorps IgE, qui se lient aux basophiles et aux mastocytes et qui peuvent déclencher la libération d'histamine, ont été associées à la gravité de l'infection par Plasmodium falciparum [20]. Outre la libération d'histamine déclenchée par les IgE, le HRF (histamine-releasing factor), un peptide décrit chez l'homme et la souris, provoque la libération d'histamine, d'IL-4, et d'IL-13 par les basophiles [21]. Ce peptide appartient à une famille de protéines appelées protéines de tumeurs contrôlées au niveau traductionnel (TCTP).…”

Section: Relations Entre Histamine Et Infection Par Plasmodiumunclassified

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

et al. 2009

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Cellular distribution of translationally controlled tumor protein in rat and human testes

et al. 2001

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In a recent proteomic study we identified 53 spermatogonial proteins among which was the translationally controlled tumor protein (TCTP). This is a protein previously reported as being implicated in proliferation events in normal and tumoral tissues that had never previously been seen in the testis. The present study was aimed at establishing the complete cellular distribution of TCTP and its transcript and the ontogenetic expression of this gene within the testis. Using an immunohistochemistry technique, an intense TCTP signal was detected in gonocytes (the prespermatogonia) in the fetal rat testis and in spermatogonia within adult human and neonatal and adult rat testes. Meiotic spermatocytes and postmeiotic haploid spermatids were also strongly immunostained in a stage-dependent manner in human and rat testes. In addition, different levels of TCTP expression were also observed in the testicular somatic cells, with strong expression in Leydig cells and peritubular cells, and weak expression in Sertoli cells. Western and Northern blot analyses confirmed the presence of TCTP at all ages studied, with higher levels of RNA expression at 9 and 20 d postpartum, when spermatogonia and primary spermatocytes represent the highest proportion of germ cells: it was also confirmed that TCTP is present in all populations of isolated testicular cells. A transcript of 0.85 kb corresponding to TCTP, was expressed at all ages studied. This transcript was found to be expressed strongly in spermatogonia, somewhat less in isolated Leydig, resident macrophage, peritubular and Sertoli cells, weakly in the primary spermatocytes but not at all in spermatids. Interestingly, in the latter, a different transcript of 1.1 kb was present. The same 1.1 kb transcript appeared in testis extracts from 35 days postpartum onwards, corresponding to an age when spermatids accumulate within the tubules. Of note is that resident macrophages were found to express both the 0.85 and the 1.1 kb transcripts. We conclude that the strong expression of TCTP in spermatogonia makes it highly likely that the protein plays a significant role in spermatogenesis.

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Molecular Identification of an IgE-Dependent Histamine-Releasing Factor

Cited by 353 publications

References 23 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

Cellular distribution of translationally controlled tumor protein in rat and human testes

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