Molecular Identification of &lt;i&gt;Fusarium&lt;/i&gt; Species in Onychomycoses

Ninet, Béatrice Alice Bescher; Jan, Isabelle; Bontems, Olympia; Léchenne, Barbara; Jousson, Olivier; Lew, Daniel Pablo; Schrenzel, Jacques; Panizzon, Renato G.; Monod, Michel

doi:10.1159/000081478

Cited by 58 publications

(43 citation statements)

References 23 publications

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“…Also, in our study, F. proliferatum was the predominant species in locally invasive infections and along with F. petroliphilum in disseminated infections [33]. The FSSC has also been reported as the most commonly isolated species complex in superficial infections, mainly keratitis and onychomycosis, in America and Asia, while the FOSC ranks first in such infections in Europe [9,[34][35][36]. Although the number of cases was low in our study, the FSSC was responsible in 85.7 % of superficial infections.…”

Section: Discussionsupporting

confidence: 63%

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Cilo

Al‐Hatmi

Seyedmousavi

et al. 2015

Eur J Clin Microbiol Infect Dis

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Fusarium species have started appearing increasingly as the main cause of infections, particularly in immunocompromised patients. In this study, we aimed to present the first epidemiological data from Turkey, analyze fusariosis cases that have been monitored in a university hospital during the past 20 years, identify the responsible Fusarium species, and determine antifungal susceptibilities. A total of 47 cases of fusariosis was included in the study. Fusarium isolates were identified by multilocus sequence typing (MLST). Antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology. Of the Fusarium infections, 23.4 % were superficial, 44.7 % were locally invasive, and 31.9 % were disseminated. A significant increase was observed over the years. The Fusarium fujikuroi species complex (FFSC) proved to be the most frequent agent group (17 cases; 51.5 %), followed by the Fusarium solani species complex (FSSC) (14 cases; 42.4 %), the Fusarium dimerum species complex (FDSC), and the Fusarium oxysporum species complexes (FOSC) (one case each). Amphotericin B had the highest in vitro activity against all species. Voriconazole and posaconazole showed interspecies variability across and within Fusarium species complexes. In conclusion, our data support the fact that regional differences exist in the distribution of the Fusarium species and that species-specific differences are observed in antifungal susceptibility patterns. The monitoring of local epidemiological data by determining fungal identity and susceptibility are of importance in guiding the clinical followup of patients.Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 63%

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Cilo

Al‐Hatmi

Seyedmousavi

et al. 2015

Eur J Clin Microbiol Infect Dis

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“…Other infecting species included Fusarium dimerum, Fusarium proliferatum, Fusarium chlamidosporum, Fusarium sacchari, Fusarium nygamai, Fusarium napiforme, Fusarium antophilum, and Fusarium vasinfectum. Fusarium solani is also the most frequent pathogen in fusarial keratitis (23) and, with F. oxysporum, accounts for most cases of onychomycosis caused by Fusarium species (12,39,73).…”

Section: Introductionmentioning

confidence: 99%

Fusarium Infections in Immunocompromised Patients

2007

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SUMMARY Fusarium species cause a broad spectrum of infections in humans, including superficial, locally invasive, and disseminated infections. The clinical form of fusariosis depends largely on the immune status of the host and the portal of entry, with superficial and localized disease occurring mostly in immunocompetent patients and invasive and disseminated disease affecting immunocompromised patients. Risk factors for severe fusariosis include prolonged neutropenia and T-cell immunodeficiency, especially in hematopoietic stem cell transplant recipients with severe graft-versus-host disease. The most frequent presentation of disseminated fusariosis is a combination of characteristic cutaneous lesions and positive blood cultures, with or without lung or sinus involvement. The prognosis is poor and is determined largely by degree of immunosuppression and extent of infection, with virtually a 100% death rate among persistently neutropenic patients with disseminated disease. These infections may be clinically suspected on the basis of a constellation of clinical and laboratory findings, which should lead to prompt therapy. Treatment options include the lipid formulations of amphotericin B, voriconazole, and posaconazole. Prevention of fusarial infection among high-risk patients should be considered.

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“…In human medicine, most cases of fusariosis affect the skin or nails (Guarro and Gené , 1995;Ninet et al, 2005;Nucci and Anaissie, 2007) and immunosuppression is considered to play a major role in the development of Fusarium infections (Nelson et al, 1994;Guarro and Gené , 1995;Nucci and Anaissie, 2007). Fusarium was isolated from the feces of animals without signs of disease and from animals that died from bacterial dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Dermatitis in Captive Wyoming Toads (Bufo Baxteri) Associated With Fusarium Spp.

Perpiñán¹,

Trupkiewicz²,

Armbrust

et al. 2010

Journal of Wildlife Diseases

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of 49 Wyoming toads (Bufo baxteri) kept at Omaha's Henry Doorly Zoo (Nebraska, USA) died showing clinical signs of ventral erythema, inappetance, lethargy, and delayed righting reflex. Treatment with antifungals and antibiotics was unsuccessful in all cases. Histopathologic analyses revealed dermatitis as the primary problem in 20 of 21 toads in which skin was examined. Fungal dermatitis was present in 17 toads, with hyphae approximately 1-3 mm in diameter, and parallel cell walls and frequent septations. In 14 animals, the fungal dermatitis was the main pathologic lesion. Several species of bacteria were associated with all cases. A few animals tested positive for Ranavirus using polymerase chain reaction. Fusarium sp. was consistently cultured from skin, feces, kidneys, and from powdered food provided to crickets. Four isolates were identified as Fusarium proliferatum, Fusarium oxysporum, Fusarium solani, and Fusarium verticillioides, which suggested a secondary role of fungi. A specific underlying cause of disease could not be found, although the roles of humidity and Ranavirus infection are discussed, along with the well-known susceptibility of bufonids to fungal dermatitis.

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Molecular Identification of <i>Fusarium</i> Species in Onychomycoses

Cited by 58 publications

References 23 publications

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Emergence of fusarioses in a university hospital in Turkey during a 20-year period

Fusarium Infections in Immunocompromised Patients

Dermatitis in Captive Wyoming Toads (Bufo Baxteri) Associated With Fusarium Spp.

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