Molecular imaging and treatment of PSMA-positive prostate cancer with 99mTc radiolabeled aptamer-siRNA chimeras

Jiao, Yuying; Xu, Peng; Luan, Sha; Wang, Xinyu; Gao, Yue; Zhao, Changjiu; Fu, Peng

doi:10.1016/j.nucmedbio.2021.11.003

Cited by 10 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Jiao et al . constructed a chimera composed of the previously mentioned PSMA-targeting A10–3.2 aptamer, a siRNA specific for mouse double minute 2 homolog (MDM2), and a bifunctional chelator for loading of the radioisotope 99m Tc for prostate cancer [ 170 ]. SPECT imaging of mice bearing PSMA-positive xenografts clearly showed tumor localization by the chimeras 30 min post-injection compared to PSMA-negative xenografts.…”

Section: Applications Of Rns For Tissue Targetingmentioning

confidence: 99%

RNA nanostructures for targeted drug delivery and imaging

Teodori,

Omer,

Kjems

2024

RNA Biology

View full text Add to dashboard Cite

The RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancements in the field of RNA nanotechnology, driving the engineering of complex nanoscale architectures toward biomedical applications, including targeted drug delivery and bioimaging. RNA polymers, serving as building blocks, offer programmability and predictability of Watson-Crick base pairing, as well as non-canonical base pairing, for the construction of nanostructures with high precision and stoichiometry. Leveraging the ease of chemical modifications to protect the RNA from degradation, researchers have developed highly functional and biocompatible RNA architectures and integrated them into preclinical studies for the delivery of payloads and imaging agents. This review offers an educational introduction to the use of RNA as a biopolymer in the design of multifunctional nanostructures applied to targeted delivery in vivo , summarizing physical and biological barriers along with strategies to overcome them. Furthermore, we highlight the most recent progress in the development of both small and larger RNA nanostructures, with a particular focus on imaging reagents and targeted cancer therapeutics in pre-clinical models and provide insights into the prospects of this rapidly evolving field.

show abstract

Section: Applications Of Rns For Tissue Targetingmentioning

confidence: 99%

RNA nanostructures for targeted drug delivery and imaging

Teodori,

Omer,

Kjems

2024

RNA Biology

View full text Add to dashboard Cite

show abstract

“…206 Since then, various radiolabeling strategies for SPECT or PET have been developed, including the use of isotopes, such as 99m Tc, 111 In, and 123 I for SPECT, and 11 C, 18 F, 68 Ga, and 64 Cu for PET. [207][208][209][210][211] Bohrmann et al developed an aptamer-targeted nanoplatform based on hyperbranched polyglycerol (HPG) to improve the stability and applicability of aptamer. 210 Their study demonstrated that the Sgc8 aptamer exhibited highly specic binding to various cancer cells and displayed good binding characteristics and biocompatibility in vitro, with an extended half-life.…”

Section: Nuclear Imagingmentioning

confidence: 99%

Engineered aptamers for molecular imaging

Lin,

Xiao,

Jiang

et al. 2023

Chem. Sci.

View full text Add to dashboard Cite

show abstract

“…A theranostic SPECT probe for the treatment of PSMA-positive prostate cancer was reported by Jiao et al . 168 who hybridized the PSMA specific RNA aptamer A10-3.2 to MDM2 siRNA and functionalized it with the chelator SHNH for labeling with 99m Tc 168 . The RNA chimeras were labeled with high radiochemical yield of 61.47% and a purity of >95%.…”

Section: Aptamers For Theranostic Applicationsmentioning

confidence: 99%

Aptamers used for molecular imaging and theranostics - recent developments

Bohrmann¹,

Burghardt²,

Haynes³

et al. 2022

Theranostics

View full text Add to dashboard Cite

Aptamers are single stranded oligonucleotides that fold into three dimensional structures and are able to recognize a variety of molecular targets. Due to the similarity to antibodies with regards to specificity and affinity and their chemical versatility, aptamers are increasingly used to create targeted probes for in vivo molecular imaging and therapy. Hence, aptamer-based probes have been utilized in practically all major imaging modalities such as nuclear imaging, magnetic resonance imaging, x-ray computed tomography, echography and fluorescence imaging, as well as newer modalities such as surface enhanced Raman spectroscopy. Aside from targeting, aptamers have been used for the creation of sensors that allow the localized detection of cellular markers such as ATP in vivo . This review focuses on in vivo studies of aptamer-based probes for imaging and theranostics since the comprehensive overview by Bouvier-Müller and Ducongé in 2018.

show abstract

Molecular imaging and treatment of PSMA-positive prostate cancer with 99mTc radiolabeled aptamer-siRNA chimeras

Cited by 10 publications

References 31 publications

RNA nanostructures for targeted drug delivery and imaging

RNA nanostructures for targeted drug delivery and imaging

Engineered aptamers for molecular imaging

Aptamers used for molecular imaging and theranostics - recent developments

Contact Info

Product

Resources

About