Molecular imaging biomarkers for dementia with Lewy bodies: an update

Mukaetova‐Ladinska, Elizabeta B.

doi:10.1017/s1041610214002555

Cited by 3 publications

(2 citation statements)

References 143 publications

(150 reference statements)

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“…DLB is a common cause of dementia, accounting for 4%–8% of dementia cases (McKeith et al , 2007 ), and it is characterized by three core clinical symptoms: cognitive fluctuations, visual hallucinations, and Parkinsonism (McKeith et al , 2005 ). There is now a growing body of neuroimaging research on DLB where this dementia is compared with AD in order to improve differential diagnosis between these two conditions, as well as to further our understanding of their neurobiological divergences (Mukaetova-Ladinska, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease

Peraza

Colloby

Deboys

et al. 2016

Int. Psychogeriatr.

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Background:Dementia with Lewy bodies (DLB) is a common cause of dementia in the elderly population after Alzheimer's disease (AD), and at early stages differential diagnosis between DLB and AD might be difficult due to their symptomatic overlap, e.g. cognitive and memory impairments. We aimed to investigate functional brain differences between both diseases in patients recently diagnosed.Methods:We investigated regional functional synchronizations using regional homogeneity (ReHo) in patients clinically diagnosed with DLB (n = 19) and AD (n = 18), and for comparisons we also included healthy controls (HC, n = 16). Patient groups were matched by age, education, and by the level of cognitive impairment (MMSE p-value = 0.36). Additionally, correlations between ReHo values and clinical scores were investigated.Results:The DLB group showed lower ReHo in sensory-motor cortices and higher ReHo in left middle temporal gyrus when compared with HCs (p-value < 0.001 uncorrected). The AD group demonstrated lower ReHo in the cerebellum and higher ReHo in the left/right lingual gyri, precuneus cortex, and other occipital and parietal regions (p-value < 0.001 uncorrected).Conclusions:Our results agree with previous ReHo investigations in Parkinson's disease (PD), suggesting that functional alterations in motor-related regions might be a characteristic of the Lewy body disease spectrum. However, our results in AD contradict previously reported findings for this disease and ReHo, which we speculate are a reflection of compensatory brain responses at early disease stages. ReHo differences between patient groups were at regions related to the default mode and sensory-motor resting state networks which might reflect the aetiological divergences in the underlying disease processes between AD and DLB.

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Section: Introductionmentioning

confidence: 99%

Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease

Peraza

Colloby

Deboys

et al. 2016

Int. Psychogeriatr.

View full text Add to dashboard Cite

show abstract

“…Lewy body dementia (LBD) affects about 1.3 million Americans and their families, making it the most common form of non-Alzheimer’s dementia [1]. Few studies have been conducted on the role of the apolipoprotein E ( APOE ) ε4 allele in LBD, but following the trajectory of past studies in Alzheimer’s disease (AD), researchers have shown that the inheritance of the ε4 allele increases a person’s risk of developing LBD [2–4] and is associated with an earlier age of death for people diagnosed with LBD [4].…”

Section: Introductionmentioning

confidence: 99%