Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles

Yan, Fei; Wu, Hao; Li, Hongmei; Deng, Zhiting; Hong, Liang; Duan, Wanlu; Liu, Xin; Zheng, Hairong

doi:10.1016/j.jconrel.2015.12.050

Cited by 218 publications

(169 citation statements)

References 46 publications

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“…Recently, the properties of carbon nanomaterials and their potential applications in PDT have been analyzed in an attempt to substitute current invasive thermal procedures that remove tumors or cancer cells of breast cancer [70][71][72][73][74][75][76][77][78][79][80][81]. Due to the carbon nanomaterials presence in the PDT, cancer cells accumulate light-sensitive molecules (carbon nanomaterials) which, in the presence of oxygen, absorb the radiation of an infrared camera and turn it into heat.…”

Section: Photodynamicmentioning

confidence: 99%

“…Due to the carbon nanomaterials presence in the PDT, cancer cells accumulate light-sensitive molecules (carbon nanomaterials) which, in the presence of oxygen, absorb the radiation of an infrared camera and turn it into heat. This induces cytotoxic effects that lead to an irreversible photodamage of cancer cells [71][72][73][74]77]. In this regard, carbon nanomaterials have been used successfully to cause thermal ablation of solid tumors in breast cancer studies [16,68,[74][75][76][79][80][81][82].…”

Section: Photodynamicmentioning

confidence: 99%

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Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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Section: Photodynamicmentioning

confidence: 99%

Section: Photodynamicmentioning

confidence: 99%

Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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“…The effectiveness of iRGD-conjugated nanocarriers has been demonstrated in multiple cases that involve a variety of nanoformulations such as liposomes 31–36 , polymer nanoparticles 37–43 , polymer nanogels 44 , polymersomes 45 , nanocapsules 46 , exosomes 47 , protein nanoparticles 48 , and inorganic nanoparticles (e.g., iron oxide nanoworms, porous silicon nanoparticles and mesoporous silica nanoparticles) 49–53 . A detail summary of studies of iRGD conjugated nanocarrier was summarized in Table 1.…”

Section: Irgd-mediated Tumor Targetingmentioning

confidence: 99%

Targeted drug delivery using iRGD peptide for solid cancer treatment

Liu

Jiang

et al. 2017

Mol. Syst. Des. Eng.

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Many solid tumor types, such as pancreatic cancer, have a generally poor prognosis, in part because the delivery of therapeutic regimen is prohibited by pathological abnormalities that block access to tumor vasculature, leading to poor bioavailability. Recent development of tumor penetrating iRGD peptide that is covalently conjugated on nanocarriers’ surface or co-administered with nanocarriers becomes a popular approach for tumor targeting. More importantly, scientists have unlocked an important tumor transcytosis mechanism by which drug carrying nanoparticles directly access solid tumors (without the need of leaky vasculature), thereby allowing systemically injected nanocarriers more abundantly distribute at tumor site with improved efficacy. In this focused review, we summarized the design and implementation strategy for iRGD-mediated tumor targeting. This includes the working principle of such peptide and discussion on patient-specific iRGD effect in vivo, commensurate with the level of key biomarker (i.e. neuropilin-1) expression on tumor vasculature. This highlights the necessity to contemplate the use of a personalized approach when iRGD technology is used in clinic.

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“…Photoacoustic imaging can also be used to perform molecular imaging (de la Zerda et al 2010;Hu et al 2015). Molecular imaging is now further evolving into the development of theranostics, agents that combine diagnostic imaging with targeted therapy (Ding et al 2013;Yan et al 2016). While currently in its infancy, molecular imaging of the retina is rapidly developing and will play a critical role in early disease diagnosis and treatment monitoring in the near future.…”

Section: Molecular Imaging and Theranosticsmentioning

confidence: 99%