Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

Garibaldi, F.; Cisbani, E.; Colilli, S.; Cusanno, F.; Giuliani, F.; Gricia, M.; Lucentini, M.; Fratoni, R.; Meo, S. Lo; Magliozzi, M.L.; Santanvenere, F.; Cinti, M.N.; Pani, R.; Pellegrini, R.; Simonetti, Giovanni; Schillaci, Orazio; Vecchio, Silvana Del; Salvatore, Marco; Majewski, S.; Lanza, R.; Vincentis, Giuseppe De; Scopinaro, Francesco

doi:10.1016/j.nima.2006.08.098

Cited by 9 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an effort to lower the dose to the patient, methods are being developed to increase sensitivity while maintaining resolution and tumour contrast so as to reduce injected radioactivity without the loss of image quality (O’Connor et al 2010). For this reason, the metrics for performance used in this and other similar studies have been relative sensitivity, tumour contrast, and SNR (Garibaldi et al 2006, Judy et al 2010, Hruska and O’Connor 2006, Hruska and O’Connor 2008). Clinical dedicated breast imaging protocols measuring 99m Tc-sestamibi distributions with pixilated CZT modules use a ±10% energy window, making it the basis for our comparisons to HPGe with various energy windows (Hruska and O’Connor 2006, Hruska and O’Connor 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Nuclear Breast Imaging (NBI), also referred to as Scintimammography, Molecular Breast Imaging (MBI) and Breast Specific Gamma Imaging (BSGI), is a technique that utilizes specifically designed gamma cameras to image the distribution of 99m Tc-sestamibi, which exhibits higher uptake in malignant tissues than healthy tissue (Delmon-Moingeon et al , 1990). These techniques have less dependence on tissue density and higher sensitivity than mammography for the detection of sub-centimeter diameter tumours (Garibaldi et al 2006, Tornai et al 2004, Mueller et al 2003, Robert et al 2011, Judy et al 2010). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Campbell¹,

Peterson²

2014

Phys. Med. Biol.

View full text Add to dashboard Cite

We conducted simulations to compare the potential imaging performance for breast cancer detection with High-Purity Germanium (HPGe) and Cadmium Zinc Telluride (CZT) systems with 1% and 3.8% energy resolution at 140 keV, respectively. Using the Monte Carlo N-Particle (MCNP5) simulation package, we modelled both 5 mm-thick CZT and 10 mm-thick HPGe detectors with the same parallel-hole collimator for the imaging of a breast/torso phantom. Simulated energy spectra were generated, and planar images were created for various energy windows around the 140-keV photopeak. Relative sensitivity and scatter and the torso fractions were calculated along with tumour contrast and signal-to-noise ratios (SNR). Simulations showed that utilizing a ±1.25% energy window with an HPGe system better suppressed torso background and small-angle scattered photons than a comparable CZT system using a −5%/+10% energy window. Both systems provided statistically similar contrast and SNR, with HPGe providing higher relative sensitivity. Lowering the counts of HPGe images to match CZT count density still yielded equivalent contrast between HPGe and CZT. Thus, an HPGe system may provide equivalent breast imaging capability at lower injected radioactivity levels when acquiring for equal imaging time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Campbell¹,

Peterson²

2014

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

“…Molecular Breast Imaging (MBI), also referred to as Breast Specific Gamma Imaging (BSGI), is a technique that utilizes specifically designed gamma cameras to image the distribution of a radiotracer, typically 99m Tc-sestamibi, which exhibits higher uptake in malignant tissues than healthy tissue [3]. These techniques have less dependence on tissue density and higher sensitivity than mammography for the detection of sub-centimeter diameter tumors [4]–[13]. …”

Section: Introductionmentioning

confidence: 99%

Molecular Breast Imaging Using Synthetic Projections From High-Purity Germanium Detectors: A Simulation Study

Campbell

Peterson

2017

IEEE Trans. Radiat. Plasma Med. Sci.

View full text Add to dashboard Cite

High-Purity Germanium (HPGe) gamma cameras are an emerging technology for Molecular Breast Imaging (MBI) due to their 2D lateral spatial resolution, depth-of-interaction (DOI) estimation, and superb energy resolution. In this simulation study, we investigate the potential imaging performance of an opposing view dual-head HPGe breast imaging system using a synthetic-projection technique, which utilizes DOI data with varying degrees of overlap in an iterative OSEM reconstruction algorithm to create 3D images from which new 2D projections are then created. The radiation transport simulator Monte Carlo N-Particle was employed to generate projections from 10-mm thick HPGe detectors using tungsten parallel-hole collimators with short and wide holes. Simulations modeling 140-keV emissions from various contrast-detail and breast-torso phantoms were conducted. Synthetic projections were generated along with conjugate-counting images from collected HPGe projections. Tumor contrast, SNR, and hot-spot detection measurements were used to compare images. Results show that the synthetic projections could resolve more low-contrast tumors compared to single-camera projections and conjugate-counting methods. MBI simulations also showed increased contrast and SNR in synthetic projections compared to individual projections. In conclusion, the HPGe imaging system employing a synthetic-projection technique may offer advantages over individual dual-camera projections or conjugate-counting methods in terms of contrast, SNR, and tumor detectability.

show abstract

Molecular breast imaging: First results from Italian-National-Institute-of-Health clinical trials

Cusanno

Cisbani

Colilli

et al. 2007

Nuclear Instruments and Methods in Physics Research Section A:

Self Cite

View full text Add to dashboard Cite

Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

Cited by 9 publications

References 16 publications

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Molecular Breast Imaging Using Synthetic Projections From High-Purity Germanium Detectors: A Simulation Study

Molecular breast imaging: First results from Italian-National-Institute-of-Health clinical trials

Contact Info

Product

Resources

About