Molecular imaging in tracking cancer stem cells: A review

Ghaffari, Hamed; Atashzar, Mohammad Reza; Abdollahi, Hamid

doi:10.47176/mjiri.34.90

Cited by 1 publication

(1 citation statement)

References 46 publications

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“…These transformations can also be monitored using advanced MRI techniques, e.g., using tumour specific promoters [ 26 ]. Another important task, the visualisation of cancer stem cells, being a rare but highly resistant subpopulation of malignant cells, is also an emerging topic in cancer treatment, since these cells possess similar characteristics to normal stem cells, as well as the substantial ability to self-renew and for extensive proliferation [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce0.8Gd0.2O2−х) synthesised using two synthetic protocols. The relaxivity of the nanoparticles was measured in a magnetic field range from 1 mT to 16.4 T. The relaxivity values (r1 = 11 ± 1.2 mM−1 s−1 and r1 = 7 ± 1.2 mM−1 s−1 in magnetic fields typical of 1.5 and 3 T MRI scanners, respectively) are considerably higher than those of the commercial Omniscan MRI contrast agent. The low toxicity of gadolinium-doped ceria nanoparticles to hMSc enables their use as an effective theranostic tool with improved MRI-contrasting properties.

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Section: Introductionmentioning

confidence: 99%