Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, Hang T.; Li, Zhen; Hagemeyer, Christoph E.; Cowin, Gary; Zhang, Shaohua; Palasubramaniam, Jathushan; Alt, Karen; Wang, Xiaowei; Peter, Karlheinz; Whittaker, Andrew K.

doi:10.1016/j.biomaterials.2017.04.037

Cited by 91 publications

(60 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the magnetic field-based strategy was utilized for various biomedical applications, there are only a few works dedicated to the use of magnetic particles in atherosclerosis therapy. Magnetic resonance imaging (MRI) represents the largest field of magnetic particles application in the context of atherosclerosis and inflammatory diseases [151]. Superparamagnetic iron oxide nanoparticles (SPIONs) act primarily to alter T2 values of water protons surrounding the particles.…”

Section: Magnetic Nanocarriers For Atherosclerosis Therapymentioning

confidence: 99%

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

et al. 2020

View full text Add to dashboard Cite

Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020.

show abstract

Section: Magnetic Nanocarriers For Atherosclerosis Therapymentioning

confidence: 99%

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although IONPs naturally become internalized by phagocytosing cells, targeting IONP contrast agents to specific markers of plaque components by attaching biological ligands to the surface of the nanoparticle increases localization and is the most common technique utilized to improve IONP specificity at atherosclerotic lesions. [35][36][37][38][39] IONPs are most commonly functionalized with antibodies through covalent bonding reactions directly to reactive surface groups 40,41 or through intermediate functional groups that have been attached prior to antibody conjugation. 42 Several groups have utilized this method with success in increasing T2-weighted MRI at areas of atherosclerotic plaque formation in vivo in mice.…”

Section: Imaging Of Atherosclerosis Using Iron Oxide Nanoparticlesmentioning

confidence: 99%

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis

Talev

Kanwar

2020

Semin Thromb Hemost

View full text Add to dashboard Cite

Atherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will first discuss current imaging techniques for the diagnosis of atherosclerosis as well as their limitations. It will then discuss the role of nanotechnology for molecular imaging of atherosclerosis and the benefits of this approach as well as reviewing current developments in the field including single, bi-, and tri-modal imaging. Next, it will discuss the role of nanotechnology for therapies of atherosclerosis with a focus on nanotheranostics, concluding with a look at the challenges faced by nanoparticle-based imaging and therapy of atherosclerosis as well as a look at future prospects.

show abstract

“…For the second of direct approaches, MRI implies the use of paramagnetic or superparamagnetic agents that alter the tissue proton relaxation time T1, T2, or T2 ∗ or manipulate the magnitude of the water signal via specially designed radiofrequency irradiation that labels one species of protons that in turn transfers the label to the water via magnetization exchange [ 56 ]. For example, Ta et al [ 57 ] reported the development of functional multimodal iron oxide nanoparticles for targeted MRI in atherosclerosis, which uses a combination of chemical and biological conjugation techniques. The ultrasmall magnetic dual-contrast iron oxide nanoparticles are used to be efficient positive and negative dual-contrast agents for magnetic resonance imaging and are also labeled with fluorescent molecules to allow for optical imaging.…”

Section: Molecular Imaging Modelsmentioning

confidence: 99%

Multimodal Molecular Imaging: Current Status and Future Directions

Shu

2018

Contrast Media & Molecular Imaging

108

View full text Add to dashboard Cite

Molecular imaging has emerged at the end of the last century as an interdisciplinary method involving in vivo imaging and molecular biology aiming at identifying living biological processes at a cellular and molecular level in a noninvasive manner. It has a profound role in determining disease changes and facilitating drug research and development, thus creating new medical modalities to monitor human health. At present, a variety of different molecular imaging techniques have their advantages, disadvantages, and limitations. In order to overcome these shortcomings, researchers combine two or more detection techniques to create a new imaging mode, such as multimodal molecular imaging, to obtain a better result and more information regarding monitoring, diagnosis, and treatment. In this review, we first describe the classic molecular imaging technology and its key advantages, and then, we offer some of the latest multimodal molecular imaging modes. Finally, we summarize the great challenges, the future development, and the great potential in this field.

show abstract

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Cited by 91 publications

References 60 publications

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis

Multimodal Molecular Imaging: Current Status and Future Directions

Contact Info

Product

Resources

About