Molecular imaging of cholinergic processes in prostate cancer using 11C-donepezil and 18F-FEOBV

Stokholm, Morten Gersel; Høyer, Søren; Borre, Michael; Bender, Dirk; Jakobsen, Steen; Frøkiær, Jørgen; Borghammer, Per

doi:10.1007/s00259-015-3143-1

Cited by 2 publications

(1 citation statement)

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“…Advance Clinical Imaging Technologies Advanced imaging technologies such as positron-emission tomography (PET) using specific neuro-molecular targets can be very useful to identify patients who exhibit, for example, cholinergic activity in the tumor or at distant sites. The uptake of PET tracers binding to cholinergic nerves (i.e., (11)C-donepezil and (18)F-FEOBV) is considerably higher in prostate cancer tissues with a high severity (Gleason) score (Stokholm et al, 2016). Development of novel neuro-molecular tracers and performance of such specific neuro-tracer-PET imaging within clinical studies may help identify patients who may specifically benefit from neuro-modulatory therapies.…”

Section: Integrate Surgeonsmentioning

confidence: 99%

Clinically Actionable Strategies for Studying Neural Influences in Cancer

et al. 2020

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Section: Integrate Surgeonsmentioning

confidence: 99%

Clinically Actionable Strategies for Studying Neural Influences in Cancer

et al. 2020

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Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

Fan,

Liang,

Tang

2024

MedComm

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Cancer neuroscience is an emerging field that investigates the intricate relationship between the nervous system and cancer, gaining increasing recognition for its importance. The central nervous system governs the development of the nervous system and directly affects brain tumors, and the peripheral nervous system (PNS) shapes the tumor microenvironment (TME) of peripheral tumors. Both systems are crucial in cancer initiation and progression, with recent studies revealing a more intricate role of the PNS within the TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating a bidirectional interaction between nerves and cancers. Notably, immune cells also contribute to this communication, forming a triangular relationship that influences protumor inflammation and the effectiveness of immunotherapy. This review delves into the intricate mechanisms connecting the PNS and tumors, focusing on how various immune cell types influence nerve‒tumor interactions, emphasizing the clinical relevance of nerve‒tumor and nerve‒immune dynamics. By deepening our understanding of the interplay between nerves, cancer, and immune cells, this review has the potential to reshape tumor biology insights, inspire innovative therapies, and improve clinical outcomes for cancer patients.

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Molecular imaging of cholinergic processes in prostate cancer using 11C-donepezil and 18F-FEOBV

Abstract: Uptake of PET tracers binding to cholinergic nerves was markedly higher in PC with a high GS than in PC with a low GS. This finding implies that (11)C-donepezil PET/CT may be able to differentiate between low-grade and high-grade PC.

Cited by 2 publications

References 15 publications

Clinically Actionable Strategies for Studying Neural Influences in Cancer

Clinically Actionable Strategies for Studying Neural Influences in Cancer

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

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