Molecular imaging of sarcomas with FDG PET

Mendoza, Humberto; Nosov, Anton; Pandit‐Taskar, Neeta

doi:10.1007/s00256-022-04182-7

Cited by 7 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PET-CT is highly sensitive in detecting pericardial lesions and can demonstrate metastatic disease, thus, additionally aiding in staging the disease and planning further treatment. 13 , 14 In our patient, PET–CT–FDG scan showed hypermetabolic pericardial spaces surrounding the heart and great vessels, pulmonary nodules and intrathoracic lymph nodes, nodular pleural thickening, and omental metastasis. Thus, for patients with recurrent pericardial effusions, the cardiac MRI or PET–CT–FDG scan can diagnose this potentially fatal pericardial tumor early.…”

Section: Discussionmentioning

confidence: 50%

A bleeding heart: case report and review of pericardial angiosarcoma

Madan,

Mahadevia,

Sharma

et al. 2024

Autops Case Rep

View full text Add to dashboard Cite

Primary cardiac tumors are rare. The cardiac sarcomas are the most common malignant cardiac tumors. These tumors have a dismal prognosis with an overall median survival of 25 months. Clinical features include dyspnea, arrhythmias, pericardial effusions, heart failure, and sudden cardiac death. The diagnosis is often challenging. Therefore, the cardiac imaging workup plays a central role in addition to a high clinical suspicion in the setting of atypical presentations that do not respond to standard therapies. The echocardiography, computed tomography, and cardiac MRI are crucial in clinching the diagnosis. Multimodal treatment with surgery, chemotherapy, and radiotherapy has been shown to improve outcomes, as opposed to using either of these modalities alone. We describe the case of a 30-year-old gentleman with COVID-19 infection who developed recurrent hemorrhagic pericardial effusions refractory to standard treatment and was eventually diagnosed as a case of pericardial angiosarcoma after his biopsy revealed the diagnosis and staging was performed using PET–CT–FDG scan. Our case re-emphasizes the importance of considering a malignant etiology early in the course of the disease presentation, especially in recurrent hemorrhagic effusions despite an inflammatory cytologic diagnosis of fluid. It also highlights the place for cardiac CT and MRI to ascertain the location and spread and to plan the further course of treatment. If diagnosed early, the estimated survival time can be prolonged by instituting a multimodal approach.

show abstract

Section: Discussionmentioning

confidence: 50%

A bleeding heart: case report and review of pericardial angiosarcoma

Madan,

Mahadevia,

Sharma

et al. 2024

Autops Case Rep

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…There has been increasing use of 18 F-FDG PET/CT in the clinical management of sarcoma. As a metabolic imaging tool, it can obtain superior diagnostic information compared with use of another imaging modality alone [19]. Bone and soft tissue sarcomas have been evaluated using 18 F-FDG PET/CT in pediatric patients.…”

Section: Screening and Diagnostic Imagingmentioning

confidence: 99%

“…Thus, the response evaluation included clinical and histological findings [31,32]. More recent studies have also suggested the future role of 18 F-FDG PET/CT in assessing initial disease staging, response to treatment, and detection of recurrence [19][20][21]. The dramatic improvement in long-term survival (70%) with combined surgical and chemotherapy treatment has sparked further interest.…”

Section: Dual Treatment With Surgery and Chemotherapymentioning

confidence: 99%

“…In an attempt to explore the genetic events of HMH tumorigenesis, capture-based next-generation sequencing (NGS) targeting these loci was performed. The identified chromosome rearrangements included translocation t (11,19) [44]. Eleven children with UESL were identified and five cases were found to be associated with HMH.…”

Section: Genetic Abnormalities and Associated Diseasementioning

confidence: 99%

See 2 more Smart Citations

Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children

Lin,

Wu,

Chen

et al. 2024

Cancers

View full text Add to dashboard Cite

Undifferentiated embryonal sarcoma of the liver is a rare mesenchymal tumor with a highly malignant potential. It occurs almost exclusively in the pediatric population and typically has a poor outcome. Although previous studies have reported dismal prognoses, recent advances in combined treatment modalities, e.g., surgery and chemotherapy, have given cause for optimism. Even in those diseases not amenable to complete surgical resection or refractory diseases, other treatment modalities, such as liver transplant, have yielded promising results. This paper provides a review of the current treatment modalities for hepatic undifferentiated embryonal sarcoma in children.

show abstract