Molecular imaging of the extracellular matrix in the context of atherosclerosis

Reimann, Carolin; Brangsch, Julia; Colletini, Federico; Walter, Thula; Hamm, Bernd; Botnar, René M.; Makowski, Marcus R.

doi:10.1016/j.addr.2016.09.005

Cited by 31 publications

(18 citation statements)

References 143 publications

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“…Initiated by these recent clinical studies on [ 89 Zr]-labelled antibodies and urged by undesired adverse events in CAR T-cell therapy [96, 103, 104, 170], these issues require whole body, quantitative imaging techniques using long-lived tracers such as PET to assess a second in vivo biodistribution following days upon first administration. Given the requisite of high affinity, high specificity and high sensitivity, other scaffolds targeting T-cell populations for PET imaging are currently under development in different disease types that might also be relevant to immunotherapy [172, 173].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Imaging of T-cells and their responses during anti-cancer immunotherapy

Krekorian¹,

Fruhwirth²,

Srinivas³

et al. 2019

Theranostics

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Immunotherapy has proven to be an effective approach in a growing number of cancers. Despite durable clinical responses achieved with antibodies targeting immune checkpoint molecules, many patients do not respond. The common denominator for immunotherapies that have successfully been introduced in the clinic is their potential to induce or enhance infiltration of cytotoxic T-cells into the tumour. However, in clinical research the molecules, cells and processes involved in effective responses during immunotherapy remain largely obscure. Therefore, in vivo imaging technologies that interrogate T-cell responses in patients represent a powerful tool to boost further development of immunotherapy. This review comprises a comprehensive analysis of the in vivo imaging technologies that allow the characterisation of T-cell responses induced by anti-cancer immunotherapy, with emphasis on technologies that are clinically available or have high translational potential. Throughout we discuss their respective strengths and weaknesses, providing arguments for selecting the optimal imaging options for future research and patient management.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Imaging of T-cells and their responses during anti-cancer immunotherapy

Krekorian¹,

Fruhwirth²,

Srinivas³

et al. 2019

Theranostics

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“…Apart from imaging infiltrating inflammatory cells, the monitoring of markers involved in cellular and molecular events underlying the pathogenesis of cardiac fibrosis and/or of highly abundant ECM components, such as integrins [213, 214], angiotensin converting enzyme [215], tissue transglutaminase [216], elastin [217], collagen [218–220], fibrin [221] and matrix metalloproteinases (MMP) [222, 223], may also provide useful information for the diagnosis and staging of cardiac fibrosis [224]. An exemplary study in this regard was published by Ziegler and colleagues, who investigated the use of scFv anti-GP2b/3a - 64 CuMeCOSar, a targeted PET tracer which binds with high affinity to the activated platelet integrin, for molecular imaging of myocardial ischemia [214].…”

Section: Non-invasive Imaging Of Fibrosismentioning

confidence: 99%

Fibrosis imaging: Current concepts and future directions

Baues

Dasgupta

Ehling

et al. 2017

Advanced Drug Delivery Reviews

121

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Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suffer from several drawbacks, including their invasive nature, sampling variability and limited spatial information. To overcome these limitations, multiple different imaging tools and technologies have been evaluated over the years, including X-ray imaging, computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT). These modalities can provide anatomical, functional and molecular imaging information which is useful for fibrosis diagnosis and staging, and they may also hold potential for the longitudinal assessment of therapy responses. Here, we summarize the use of non-invasive imaging techniques for monitoring fibrosis in systemic autoimmune diseases, in parenchymal organs (such as liver, kidney, lung and heart), and in desmoplastic cancers. We also discuss how imaging biomarkers can be integrated in (pre-) clinical research to individualize and improve anti-fibrotic therapies.

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“…The average diameters of the rabbit aorta measured by OCT and angiograph images were 3.17 ± 0.49 mm and 3.15 ± 0.32 mm, respectively, similar to the size of human coronary arteries 64 , 65 , showing the clinical validity of the experiment 58 , 66 . Normal rabbit aorta is a type of elastic artery mainly composed of collagen and elastin 67 , 68 . In contrast, atherosclerotic lesions in the rabbit aorta are characterized by increase in lipid accumulation, infiltration of macrophages, and formation of collagen type I 50 , as shown in our results.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

Lee

Song

Kang

et al. 2018

Sci Rep

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Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an atherosclerotic rabbit artery in vivo. Especially, the autofluorescence lifetime of the endogenous tissue molecules can be used to characterize the biochemical composition; thus no exogenous contrast agent is required. Also, the physical properties of the imaging catheter and the imaging procedures are similar to those already used clinically, facilitating rapid translation into clinical use. This new intravascular imaging catheter can open up new opportunities for clinicians and researchers to investigate and diagnose coronary artery disease by simultaneously providing tissue microstructure and biochemical composition data in vivo without the use of exogenous contrast agent.

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Molecular imaging of the extracellular matrix in the context of atherosclerosis

Cited by 31 publications

References 143 publications

Imaging of T-cells and their responses during anti-cancer immunotherapy

Imaging of T-cells and their responses during anti-cancer immunotherapy

Fibrosis imaging: Current concepts and future directions

Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

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